Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors
<p>Abstract</p> <p>Background</p> <p>Lung cancer in young patients (less or equal to 45 years) is uncommon and has clinical characteristics different from that in older patients. We investigated the outcomes and prognostic factors of young patients with advanced non-sma...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | BMC Cancer |
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| Online Access: | http://www.biomedcentral.com/1471-2407/12/241 |
| _version_ | 1818641436377088000 |
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| author | Hsu Chia-Lin Chen Kuan-Yu Shih Jin-Yuan Ho Chao-Chi Yang Chih-Hsin Yu Chong-Jen Yang Pan-Chyr |
| author_facet | Hsu Chia-Lin Chen Kuan-Yu Shih Jin-Yuan Ho Chao-Chi Yang Chih-Hsin Yu Chong-Jen Yang Pan-Chyr |
| author_sort | Hsu Chia-Lin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Lung cancer in young patients (less or equal to 45 years) is uncommon and has clinical characteristics different from that in older patients. We investigated the outcomes and prognostic factors of young patients with advanced non-small cell lung cancer (NSCLC).</p> <p>Methods</p> <p>From January 2000 to December 2009, we enrolled patients aged ≤45 years and diagnosed with stage IIIB or IV NSCLC. Their clinical data, including age, gender, performance status, histologic types, disease stages, laboratory data at diagnosis, treatment modalities, and survival were reviewed and analyzed. A Cox proportional hazard model was used to calculate the hazard ratio (HR) and its 95% confidence interval (CI).</p> <p>Results</p> <p>A total of 144 patients with advanced NSCLC were included. Female patients were more prevalent (n = 74, 51.4%). Adenocarcinoma was the most common histologic type (n = 119, 82.6%) in both genders (male, n = 54, 77.1%; female, n = 65, 87.8%). Epidermal growth factor receptor (<it>EGFR)</it> sequences were determined using tumor specimens from 58 patients, and 29 showed an <it>EGFR</it> mutation. No significant difference in median survival was found between patient groups with and without the <it>EGFR</it> mutation (798 vs. 708 days, <it>p</it> = 0.65). In multivariate analysis, male gender (HR, 1.70; 95% CI: 1.08-2.68), body mass index (BMI) less than 25 kg/m<sup>2</sup> (HR, 2.72; 95% CI: 1.39-5.30), stage IV disease (HR, 2.62; 95% CI: 1.50-4.57), and anemia (HR, 2.08; 95% CI: 1.15-3.77) were associated with a short survival time.</p> <p>Conclusions</p> <p>Low BMI, stage IV disease, anemia at diagnosis, and male gender were the negative prognostic factors for young patients with advanced NSCLC.</p> |
| first_indexed | 2024-12-16T23:27:08Z |
| format | Article |
| id | doaj.art-64810b8015ab44e6b98c53434786d85b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-16T23:27:08Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-64810b8015ab44e6b98c53434786d85b2022-12-21T22:11:59ZengBMCBMC Cancer1471-24072012-06-0112124110.1186/1471-2407-12-241Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factorsHsu Chia-LinChen Kuan-YuShih Jin-YuanHo Chao-ChiYang Chih-HsinYu Chong-JenYang Pan-Chyr<p>Abstract</p> <p>Background</p> <p>Lung cancer in young patients (less or equal to 45 years) is uncommon and has clinical characteristics different from that in older patients. We investigated the outcomes and prognostic factors of young patients with advanced non-small cell lung cancer (NSCLC).</p> <p>Methods</p> <p>From January 2000 to December 2009, we enrolled patients aged ≤45 years and diagnosed with stage IIIB or IV NSCLC. Their clinical data, including age, gender, performance status, histologic types, disease stages, laboratory data at diagnosis, treatment modalities, and survival were reviewed and analyzed. A Cox proportional hazard model was used to calculate the hazard ratio (HR) and its 95% confidence interval (CI).</p> <p>Results</p> <p>A total of 144 patients with advanced NSCLC were included. Female patients were more prevalent (n = 74, 51.4%). Adenocarcinoma was the most common histologic type (n = 119, 82.6%) in both genders (male, n = 54, 77.1%; female, n = 65, 87.8%). Epidermal growth factor receptor (<it>EGFR)</it> sequences were determined using tumor specimens from 58 patients, and 29 showed an <it>EGFR</it> mutation. No significant difference in median survival was found between patient groups with and without the <it>EGFR</it> mutation (798 vs. 708 days, <it>p</it> = 0.65). In multivariate analysis, male gender (HR, 1.70; 95% CI: 1.08-2.68), body mass index (BMI) less than 25 kg/m<sup>2</sup> (HR, 2.72; 95% CI: 1.39-5.30), stage IV disease (HR, 2.62; 95% CI: 1.50-4.57), and anemia (HR, 2.08; 95% CI: 1.15-3.77) were associated with a short survival time.</p> <p>Conclusions</p> <p>Low BMI, stage IV disease, anemia at diagnosis, and male gender were the negative prognostic factors for young patients with advanced NSCLC.</p>http://www.biomedcentral.com/1471-2407/12/241Lung cancerPrognosisYoung patients |
| spellingShingle | Hsu Chia-Lin Chen Kuan-Yu Shih Jin-Yuan Ho Chao-Chi Yang Chih-Hsin Yu Chong-Jen Yang Pan-Chyr Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors BMC Cancer Lung cancer Prognosis Young patients |
| title | Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors |
| title_full | Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors |
| title_fullStr | Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors |
| title_full_unstemmed | Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors |
| title_short | Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors |
| title_sort | advanced non small cell lung cancer in patients aged 45 years or younger outcomes and prognostic factors |
| topic | Lung cancer Prognosis Young patients |
| url | http://www.biomedcentral.com/1471-2407/12/241 |
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