Systematic review of long-term Xingnao Kaiqiao needling effcacy in ischemic stroke treatment
OBJECTIVE: To systematically evaluate the long-term effect and safety of Xingnao Kaiqiao needling method in ischemic stroke treatment. DATA RETRIEVAL: We retrieved relevant random and semi-random controlled trials that used the Xingnao Kaiqiao needling method to treat ischemic stroke compared with v...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=583;epage=588;aulast=Yang |
| _version_ | 1818529687164420096 |
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| author | Zhi-xin Yang Jia-hong Xie Yong-ping Liu Guang-xin Miao Ying-han Wang Sheng-mei Wu Yuan Li |
| author_facet | Zhi-xin Yang Jia-hong Xie Yong-ping Liu Guang-xin Miao Ying-han Wang Sheng-mei Wu Yuan Li |
| author_sort | Zhi-xin Yang |
| collection | DOAJ |
| description | OBJECTIVE: To systematically evaluate the long-term effect and safety of Xingnao Kaiqiao needling method in ischemic stroke treatment.
DATA RETRIEVAL: We retrieved relevant random and semi-random controlled trials that used the Xingnao Kaiqiao needling method to treat ischemic stroke compared with various control treatments such as conventional drugs or other acupuncture therapies. Searched databases included China National Knowledge Infrastructure, Weipu Information Resources System, Wanfang Medical Data System, Chinese Biomedical Literature Database, Cochrane Library, and PubMed, from May 2006 to July 2014.
SELECTION CRITERIA: Two authors independently conducted literature screening, quality evaluation, and data extraction. The quality of articles was evaluated according to the Cochrane Reviewers′Handbook 5.1, and the study was carried out using Cochrane system assessment methods. RevMan 5.2 was used for meta-analysis of the included studies.
MAIN OUTCOME MEASURES: Mortality rate, recurrence rate, and disability rate were observed.
RESULTS: Nine randomized and semi-randomized controlled trials treating 931 cases of ischemic stroke were included in this review. Meta-analysis results showed that there were no significant differences in mortality reduction (risk ratio (RR) = 0.58, 95% confidence interval (CI): 0.17-1.93, Z = 0.89, P = 0.37) or recurrence rate (RR = 0.55, 95%CI: 0.18-1.70, Z = 1.04, P = 0.30) of ischemic stroke patients between the Xingnao Kaiqiao needling and control treatment groups. However, the Xingnao Kaiqiao needling method had a tendency towards higher efficacy in mortality reduction and recurrence rates. The Xingnao Kaiqiao needling method was significantly better than that of the control treatment in reducing disability rate (RR = 0.51, 95%CI: 0.27-0.98, Z = 2.03, P < 0.05).
CONCLUSION: The Xingnao Kaiqiao needling method has a better effect than control treatment in reducing disability rate. The long-term effect of Xingnao Kaiqiao needling against ischemic stroke is better than that of control treatment. However, the limitations of this study limit the strength of the conclusions. Randomized controlled trials with a strict, reasonable design, and multi-center, large-scale samples and follow-up are necessary to draw conclusions about Xingnao Kaiqiao needling. |
| first_indexed | 2024-12-11T17:10:03Z |
| format | Article |
| id | doaj.art-6483f18487d5481c95bbd574d6cd0c36 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-11T17:10:03Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Neural Regeneration Research |
| spelling | doaj.art-6483f18487d5481c95bbd574d6cd0c362022-12-22T00:57:34ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110458358810.4103/1673-5374.155431Systematic review of long-term Xingnao Kaiqiao needling effcacy in ischemic stroke treatmentZhi-xin YangJia-hong XieYong-ping LiuGuang-xin MiaoYing-han WangSheng-mei WuYuan LiOBJECTIVE: To systematically evaluate the long-term effect and safety of Xingnao Kaiqiao needling method in ischemic stroke treatment. DATA RETRIEVAL: We retrieved relevant random and semi-random controlled trials that used the Xingnao Kaiqiao needling method to treat ischemic stroke compared with various control treatments such as conventional drugs or other acupuncture therapies. Searched databases included China National Knowledge Infrastructure, Weipu Information Resources System, Wanfang Medical Data System, Chinese Biomedical Literature Database, Cochrane Library, and PubMed, from May 2006 to July 2014. SELECTION CRITERIA: Two authors independently conducted literature screening, quality evaluation, and data extraction. The quality of articles was evaluated according to the Cochrane Reviewers′Handbook 5.1, and the study was carried out using Cochrane system assessment methods. RevMan 5.2 was used for meta-analysis of the included studies. MAIN OUTCOME MEASURES: Mortality rate, recurrence rate, and disability rate were observed. RESULTS: Nine randomized and semi-randomized controlled trials treating 931 cases of ischemic stroke were included in this review. Meta-analysis results showed that there were no significant differences in mortality reduction (risk ratio (RR) = 0.58, 95% confidence interval (CI): 0.17-1.93, Z = 0.89, P = 0.37) or recurrence rate (RR = 0.55, 95%CI: 0.18-1.70, Z = 1.04, P = 0.30) of ischemic stroke patients between the Xingnao Kaiqiao needling and control treatment groups. However, the Xingnao Kaiqiao needling method had a tendency towards higher efficacy in mortality reduction and recurrence rates. The Xingnao Kaiqiao needling method was significantly better than that of the control treatment in reducing disability rate (RR = 0.51, 95%CI: 0.27-0.98, Z = 2.03, P < 0.05). CONCLUSION: The Xingnao Kaiqiao needling method has a better effect than control treatment in reducing disability rate. The long-term effect of Xingnao Kaiqiao needling against ischemic stroke is better than that of control treatment. However, the limitations of this study limit the strength of the conclusions. Randomized controlled trials with a strict, reasonable design, and multi-center, large-scale samples and follow-up are necessary to draw conclusions about Xingnao Kaiqiao needling.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=583;epage=588;aulast=Yangspinal cord injurypropriospinal systemneural plasticityfiber sproutingneural repaircompensationregenerationpropriospinal detoursneurotrophic factorscell-adhesive ligandsdorsal root gangliaL1CAMnerve growth factorbiomaterialselastin-like proteinsAlzheimer′s diseaseAMPKapoptosisautophagycentral nervous systemCCN4EGFdiabetes mellituserythropoietinEPOFGFIGF-1mTORneuronneuropathyoxidative stresspsychiatricstem cellsWISP1Wntperipheral nerve injurynerve graftnerve conduitWallerian degenerationneurotrophic factorsveinsautograftsnerve regenerationnerve regenerationneuroprotectionresveratrolcerebral ischemiacerebral infarctionmatrix metalloproteinasemolecular dockingextracellular matrixneural regenerationnerve regenerationvagus nerve stimulationcerebral ischemiainflammatory cytokinesinfarct volumeneurological functionNSFC grantsneural regenerationnerve regenerationXingnao Kaiqiao needling methodischemic strokerandomized controlled trialsystemic reviewsmeta-analysislong-term efficacymortalityrecurrencedisabilityadverse reactionshealth economics indicatorsneural regeneration |
| spellingShingle | Zhi-xin Yang Jia-hong Xie Yong-ping Liu Guang-xin Miao Ying-han Wang Sheng-mei Wu Yuan Li Systematic review of long-term Xingnao Kaiqiao needling effcacy in ischemic stroke treatment Neural Regeneration Research spinal cord injury propriospinal system neural plasticity fiber sprouting neural repair compensation regeneration propriospinal detours neurotrophic factors cell-adhesive ligands dorsal root ganglia L1CAM nerve growth factor biomaterials elastin-like proteins Alzheimer′s disease AMPK apoptosis autophagy central nervous system CCN4 EGF diabetes mellitus erythropoietin EPO FGF IGF-1 mTOR neuron neuropathy oxidative stress psychiatric stem cells WISP1 Wnt peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration nerve regeneration neuroprotection resveratrol cerebral ischemia cerebral infarction matrix metalloproteinase molecular docking extracellular matrix neural regeneration nerve regeneration vagus nerve stimulation cerebral ischemia inflammatory cytokines infarct volume neurological function NSFC grants neural regeneration nerve regeneration Xingnao Kaiqiao needling method ischemic stroke randomized controlled trial systemic reviews meta-analysis long-term efficacy mortality recurrence disability adverse reactions health economics indicators neural regeneration |
| title | Systematic review of long-term Xingnao Kaiqiao needling effcacy in ischemic stroke treatment |
| title_full | Systematic review of long-term Xingnao Kaiqiao needling effcacy in ischemic stroke treatment |
| title_fullStr | Systematic review of long-term Xingnao Kaiqiao needling effcacy in ischemic stroke treatment |
| title_full_unstemmed | Systematic review of long-term Xingnao Kaiqiao needling effcacy in ischemic stroke treatment |
| title_short | Systematic review of long-term Xingnao Kaiqiao needling effcacy in ischemic stroke treatment |
| title_sort | systematic review of long term xingnao kaiqiao needling effcacy in ischemic stroke treatment |
| topic | spinal cord injury propriospinal system neural plasticity fiber sprouting neural repair compensation regeneration propriospinal detours neurotrophic factors cell-adhesive ligands dorsal root ganglia L1CAM nerve growth factor biomaterials elastin-like proteins Alzheimer′s disease AMPK apoptosis autophagy central nervous system CCN4 EGF diabetes mellitus erythropoietin EPO FGF IGF-1 mTOR neuron neuropathy oxidative stress psychiatric stem cells WISP1 Wnt peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration nerve regeneration neuroprotection resveratrol cerebral ischemia cerebral infarction matrix metalloproteinase molecular docking extracellular matrix neural regeneration nerve regeneration vagus nerve stimulation cerebral ischemia inflammatory cytokines infarct volume neurological function NSFC grants neural regeneration nerve regeneration Xingnao Kaiqiao needling method ischemic stroke randomized controlled trial systemic reviews meta-analysis long-term efficacy mortality recurrence disability adverse reactions health economics indicators neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=583;epage=588;aulast=Yang |
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