Optimal Abdominal CT Image Quality in Non-Lean Patients: Customization of CM Injection Protocols and Low-Energy Acquisitions
We compared the image quality of abdominopelvic single-energy CT with 100 kVp (SECT-100 kVp) and dual-energy CT with 65 keV (DECT-65 keV) obtained with customized injection protocols to standard abdominopelvic CT scans (SECT-120 kVp) with fixed volumes of contrast media (CM). We retrospectively incl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/13/2279 |
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| author | Francesco Macri Elina Khasanova Bonnie T. Niu Anushri Parakh Manuel Patino Avinash Kambadakone Dushyant V. Sahani |
| author_facet | Francesco Macri Elina Khasanova Bonnie T. Niu Anushri Parakh Manuel Patino Avinash Kambadakone Dushyant V. Sahani |
| author_sort | Francesco Macri |
| collection | DOAJ |
| description | We compared the image quality of abdominopelvic single-energy CT with 100 kVp (SECT-100 kVp) and dual-energy CT with 65 keV (DECT-65 keV) obtained with customized injection protocols to standard abdominopelvic CT scans (SECT-120 kVp) with fixed volumes of contrast media (CM). We retrospectively included 91 patients (mean age, 60.7 ± 15.8 years) with SECT-100 kVp and 83 (mean age, 60.3 ± 11.7 years) patients with DECT-65 keV in portovenous phase. Total body weight-based customized injection protocols were generated by a software using the following formula: patient weight (kg) × 0.40/contrast concentration (mgI/mL) × 1000. Patients had a prior abdominopelvic SECT-120 kVp with fixed injection. Iopamidol-370 was administered for all examinations. Quantitative and qualitative image quality comparisons were made between customized and fixed injection protocols. Compared to SECT-120 kVp, customized injection yielded a significant reduction in CM volume (mean difference = 9–12 mL; <i>p</i> ≤ 0.001) and injection rate (mean differences = 0.2–0.4 mL/s; <i>p</i> ≤ 0.001) in all weight categories. Improvements in attenuation, noise, signal-to-noise and contrast-to-noise ratios were observed for both SECT-100 kVp and DECT-65 keV compared to SECT-120 kVp in all weight categories (e.g., pancreas DECT-65 keV, 1.2-attenuation-fold increase vs. SECT-120 kVp; <i>p</i> < 0.001). Qualitative scores were ≥4 in 172 cases (98.8.4%) with customized injections and in all cases with fixed injections (100%). These findings suggest that customized CM injection protocols may substantially reduce iodine dose while yielding higher image quality in SECT-100 kVp and DECT-65 keV abdominopelvic scans compared to SECT-120 kVp using fixed CM volumes. |
| first_indexed | 2024-03-11T01:43:59Z |
| format | Article |
| id | doaj.art-6485bab88c044dcda95848b23d0c7f9d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T01:43:59Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6485bab88c044dcda95848b23d0c7f9d2023-11-18T16:22:31ZengMDPI AGDiagnostics2075-44182023-07-011313227910.3390/diagnostics13132279Optimal Abdominal CT Image Quality in Non-Lean Patients: Customization of CM Injection Protocols and Low-Energy AcquisitionsFrancesco Macri0Elina Khasanova1Bonnie T. Niu2Anushri Parakh3Manuel Patino4Avinash Kambadakone5Dushyant V. Sahani6Department of Radiology, Geneva University Hospitals, University of Geneva, 1211 Geneva, SwitzerlandDepartment of Radiology, Geneva University Hospitals, University of Geneva, 1211 Geneva, SwitzerlandFaculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, CanadaDepartment of Radiology, Abdominal Division, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Radiology, Abdominal Division, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Radiology, Abdominal Division, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Radiology, University of Washington, Seattle, WA 98195, USAWe compared the image quality of abdominopelvic single-energy CT with 100 kVp (SECT-100 kVp) and dual-energy CT with 65 keV (DECT-65 keV) obtained with customized injection protocols to standard abdominopelvic CT scans (SECT-120 kVp) with fixed volumes of contrast media (CM). We retrospectively included 91 patients (mean age, 60.7 ± 15.8 years) with SECT-100 kVp and 83 (mean age, 60.3 ± 11.7 years) patients with DECT-65 keV in portovenous phase. Total body weight-based customized injection protocols were generated by a software using the following formula: patient weight (kg) × 0.40/contrast concentration (mgI/mL) × 1000. Patients had a prior abdominopelvic SECT-120 kVp with fixed injection. Iopamidol-370 was administered for all examinations. Quantitative and qualitative image quality comparisons were made between customized and fixed injection protocols. Compared to SECT-120 kVp, customized injection yielded a significant reduction in CM volume (mean difference = 9–12 mL; <i>p</i> ≤ 0.001) and injection rate (mean differences = 0.2–0.4 mL/s; <i>p</i> ≤ 0.001) in all weight categories. Improvements in attenuation, noise, signal-to-noise and contrast-to-noise ratios were observed for both SECT-100 kVp and DECT-65 keV compared to SECT-120 kVp in all weight categories (e.g., pancreas DECT-65 keV, 1.2-attenuation-fold increase vs. SECT-120 kVp; <i>p</i> < 0.001). Qualitative scores were ≥4 in 172 cases (98.8.4%) with customized injections and in all cases with fixed injections (100%). These findings suggest that customized CM injection protocols may substantially reduce iodine dose while yielding higher image quality in SECT-100 kVp and DECT-65 keV abdominopelvic scans compared to SECT-120 kVp using fixed CM volumes.https://www.mdpi.com/2075-4418/13/13/2279computed tomographycontrast materialimage quality enhancementworkflow |
| spellingShingle | Francesco Macri Elina Khasanova Bonnie T. Niu Anushri Parakh Manuel Patino Avinash Kambadakone Dushyant V. Sahani Optimal Abdominal CT Image Quality in Non-Lean Patients: Customization of CM Injection Protocols and Low-Energy Acquisitions Diagnostics computed tomography contrast material image quality enhancement workflow |
| title | Optimal Abdominal CT Image Quality in Non-Lean Patients: Customization of CM Injection Protocols and Low-Energy Acquisitions |
| title_full | Optimal Abdominal CT Image Quality in Non-Lean Patients: Customization of CM Injection Protocols and Low-Energy Acquisitions |
| title_fullStr | Optimal Abdominal CT Image Quality in Non-Lean Patients: Customization of CM Injection Protocols and Low-Energy Acquisitions |
| title_full_unstemmed | Optimal Abdominal CT Image Quality in Non-Lean Patients: Customization of CM Injection Protocols and Low-Energy Acquisitions |
| title_short | Optimal Abdominal CT Image Quality in Non-Lean Patients: Customization of CM Injection Protocols and Low-Energy Acquisitions |
| title_sort | optimal abdominal ct image quality in non lean patients customization of cm injection protocols and low energy acquisitions |
| topic | computed tomography contrast material image quality enhancement workflow |
| url | https://www.mdpi.com/2075-4418/13/13/2279 |
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