Resveratrol Mitigates Metabolism in Human Microglia Cells
The recognition of the role of microglia cells in neurodegenerative diseases has steadily increased over the past few years. There is growing evidence that the uncontrolled and persisting activation of microglial cells is involved in the progression of diseases such as Alzheimer’s or Parkinson’s dis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/6/1248 |
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| author | Luise Schlotterose Mariya S. Pravdivtseva Frowin Ellermann Olav Jansen Jan-Bernd Hövener Frank D. Sönnichsen François Cossais Ralph Lucius Kirsten Hattermann |
| author_facet | Luise Schlotterose Mariya S. Pravdivtseva Frowin Ellermann Olav Jansen Jan-Bernd Hövener Frank D. Sönnichsen François Cossais Ralph Lucius Kirsten Hattermann |
| author_sort | Luise Schlotterose |
| collection | DOAJ |
| description | The recognition of the role of microglia cells in neurodegenerative diseases has steadily increased over the past few years. There is growing evidence that the uncontrolled and persisting activation of microglial cells is involved in the progression of diseases such as Alzheimer’s or Parkinson’s disease. The inflammatory activation of microglia cells is often accompanied by a switch in metabolism to higher glucose consumption and aerobic glycolysis. In this study, we investigate the changes induced by the natural antioxidant resveratrol in a human microglia cell line. Resveratrol is renowned for its neuroprotective properties, but little is known about its direct effect on human microglia cells. By analyzing a variety of inflammatory, neuroprotective, and metabolic aspects, resveratrol was observed to reduce inflammasome activity, increase the release of insulin-like growth factor 1, decrease glucose uptake, lower mitochondrial activity, and attenuate cellular metabolism in a <sup>1</sup>H NMR-based analysis of whole-cell extracts. To this end, studies were mainly performed by analyzing the effect of exogenous stressors such as lipopolysaccharide or interferon gamma on the metabolic profile of microglial cells. Therefore, this study focuses on changes in metabolism without any exogenous stressors, demonstrating how resveratrol might provide protection from persisting neuroinflammation. |
| first_indexed | 2024-03-11T02:49:42Z |
| format | Article |
| id | doaj.art-64862e6961b145998bdccadd88d4e952 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T02:49:42Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-64862e6961b145998bdccadd88d4e9522023-11-18T09:03:31ZengMDPI AGAntioxidants2076-39212023-06-01126124810.3390/antiox12061248Resveratrol Mitigates Metabolism in Human Microglia CellsLuise Schlotterose0Mariya S. Pravdivtseva1Frowin Ellermann2Olav Jansen3Jan-Bernd Hövener4Frank D. Sönnichsen5François Cossais6Ralph Lucius7Kirsten Hattermann8Institute of Anatomy, Kiel University, 24118 Kiel, GermanySection Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, 24105 Kiel, GermanySection Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, 24105 Kiel, GermanyDepartment of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, 24105 Kiel, GermanySection Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, 24105 Kiel, GermanyOtto Diels Institute for Organic Chemistry, Kiel University, 24118 Kiel, GermanyInstitute of Anatomy, Kiel University, 24118 Kiel, GermanyInstitute of Anatomy, Kiel University, 24118 Kiel, GermanyInstitute of Anatomy, Kiel University, 24118 Kiel, GermanyThe recognition of the role of microglia cells in neurodegenerative diseases has steadily increased over the past few years. There is growing evidence that the uncontrolled and persisting activation of microglial cells is involved in the progression of diseases such as Alzheimer’s or Parkinson’s disease. The inflammatory activation of microglia cells is often accompanied by a switch in metabolism to higher glucose consumption and aerobic glycolysis. In this study, we investigate the changes induced by the natural antioxidant resveratrol in a human microglia cell line. Resveratrol is renowned for its neuroprotective properties, but little is known about its direct effect on human microglia cells. By analyzing a variety of inflammatory, neuroprotective, and metabolic aspects, resveratrol was observed to reduce inflammasome activity, increase the release of insulin-like growth factor 1, decrease glucose uptake, lower mitochondrial activity, and attenuate cellular metabolism in a <sup>1</sup>H NMR-based analysis of whole-cell extracts. To this end, studies were mainly performed by analyzing the effect of exogenous stressors such as lipopolysaccharide or interferon gamma on the metabolic profile of microglial cells. Therefore, this study focuses on changes in metabolism without any exogenous stressors, demonstrating how resveratrol might provide protection from persisting neuroinflammation.https://www.mdpi.com/2076-3921/12/6/1248resveratrolneuroinflammationneurodegenerative diseasesmetabolismM1/M2 microglia |
| spellingShingle | Luise Schlotterose Mariya S. Pravdivtseva Frowin Ellermann Olav Jansen Jan-Bernd Hövener Frank D. Sönnichsen François Cossais Ralph Lucius Kirsten Hattermann Resveratrol Mitigates Metabolism in Human Microglia Cells Antioxidants resveratrol neuroinflammation neurodegenerative diseases metabolism M1/M2 microglia |
| title | Resveratrol Mitigates Metabolism in Human Microglia Cells |
| title_full | Resveratrol Mitigates Metabolism in Human Microglia Cells |
| title_fullStr | Resveratrol Mitigates Metabolism in Human Microglia Cells |
| title_full_unstemmed | Resveratrol Mitigates Metabolism in Human Microglia Cells |
| title_short | Resveratrol Mitigates Metabolism in Human Microglia Cells |
| title_sort | resveratrol mitigates metabolism in human microglia cells |
| topic | resveratrol neuroinflammation neurodegenerative diseases metabolism M1/M2 microglia |
| url | https://www.mdpi.com/2076-3921/12/6/1248 |
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