Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
The clinical picture of primary hyperparathyroidism (PHPT) which caused by parathyroid neoplasms often includes metabolic syndrome leading to the development of cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipide...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2021-01-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/12436 |
| _version_ | 1826588048813457408 |
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| author | Ekaterina E. Bibik [Anna K. Eremkina Julia A. Krupinova Natalia V. Klementieva Ekaterina A. Dobreva Natalia G. Mokrysheva |
| author_facet | Ekaterina E. Bibik [Anna K. Eremkina Julia A. Krupinova Natalia V. Klementieva Ekaterina A. Dobreva Natalia G. Mokrysheva |
| author_sort | Ekaterina E. Bibik |
| collection | DOAJ |
| description | The clinical picture of primary hyperparathyroidism (PHPT) which caused by parathyroid neoplasms often includes metabolic syndrome leading to the development of cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia and other disorders that signifi tly affect the life span and quality are observed in patients with PHPT regardless of the form and the severity of the underlying disease. Basic research shows the potential nonclassical effects of high levels of parathyroid hormone and calcium on adipose tissue, pancreas, gastrointestinal tract and kidneys. However, the pathogenetic mechanisms of impaired carbohydrate and other types of metabolism in patients with parathyroid hyperfunction remain unclear because of the lack of relevant experimental models and the heterogeneity of patient groups. Besides, the effect of surgery on metabolic abnormalities is also controversial. Nowadays a deeper understanding of this issue is required, which can subsequently help in the creation of optimal approach to diagnosis and treatment of patients. This review covers different aspects of metabolic disorders in patients with PHPT, as well as potential key factors of their development. |
| first_indexed | 2024-03-08T15:20:12Z |
| format | Article |
| id | doaj.art-648637706a8547879ee395ca19a207d6 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2025-03-14T16:35:08Z |
| publishDate | 2021-01-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-648637706a8547879ee395ca19a207d62025-02-21T09:29:37ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782021-01-0123545946610.14341/DM1243610848Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidismEkaterina E. Bibik0[Anna K. Eremkina1Julia A. Krupinova2Natalia V. Klementieva3Ekaterina A. Dobreva4Natalia G. Mokrysheva5Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreThe clinical picture of primary hyperparathyroidism (PHPT) which caused by parathyroid neoplasms often includes metabolic syndrome leading to the development of cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia and other disorders that signifi tly affect the life span and quality are observed in patients with PHPT regardless of the form and the severity of the underlying disease. Basic research shows the potential nonclassical effects of high levels of parathyroid hormone and calcium on adipose tissue, pancreas, gastrointestinal tract and kidneys. However, the pathogenetic mechanisms of impaired carbohydrate and other types of metabolism in patients with parathyroid hyperfunction remain unclear because of the lack of relevant experimental models and the heterogeneity of patient groups. Besides, the effect of surgery on metabolic abnormalities is also controversial. Nowadays a deeper understanding of this issue is required, which can subsequently help in the creation of optimal approach to diagnosis and treatment of patients. This review covers different aspects of metabolic disorders in patients with PHPT, as well as potential key factors of their development.https://www.dia-endojournals.ru/jour/article/view/12436primary hyperparathyroidism, parathyroid hormone, hypercalcemia, diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia |
| spellingShingle | Ekaterina E. Bibik [Anna K. Eremkina Julia A. Krupinova Natalia V. Klementieva Ekaterina A. Dobreva Natalia G. Mokrysheva Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism Сахарный диабет primary hyperparathyroidism, parathyroid hormone, hypercalcemia, diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia |
| title | Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism |
| title_full | Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism |
| title_fullStr | Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism |
| title_full_unstemmed | Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism |
| title_short | Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism |
| title_sort | impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism |
| topic | primary hyperparathyroidism, parathyroid hormone, hypercalcemia, diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia |
| url | https://www.dia-endojournals.ru/jour/article/view/12436 |
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