The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors
Abstract Exposure to magnetic field (MF) can affect cellular metabolism remotely. Cardio-toxic effects of Doxorubicin (DOXO) have limited clinical uses at high dose. MF due to its effect on reactive oxygen species (ROS) lifetime, may provide a suitable choice to boost the efficacy of this drug at lo...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-19247-8 |
| _version_ | 1818993681626038272 |
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| author | Behnam Hajipour Verdom Parviz Abdolmaleki Mehrdad Behmanesh |
| author_facet | Behnam Hajipour Verdom Parviz Abdolmaleki Mehrdad Behmanesh |
| author_sort | Behnam Hajipour Verdom |
| collection | DOAJ |
| description | Abstract Exposure to magnetic field (MF) can affect cellular metabolism remotely. Cardio-toxic effects of Doxorubicin (DOXO) have limited clinical uses at high dose. MF due to its effect on reactive oxygen species (ROS) lifetime, may provide a suitable choice to boost the efficacy of this drug at low dose. Here, we investigated the potential effects of homogenous static magnetic field (SMF) on DOXO-induced toxicity and proliferation rate of cancer cells. The results indicated that SMF similar to DOXO decreased the cell viability as well as the proliferation rate of MCF-7 and HFF cells. Moreover, combination of 10 mT SMF and 0.1 µM DOXO decreased the viability and proliferation rate of cancer and normal cells in a synergetic manner. In spite of high a GSH level in cancer cell, SMF boosts the generation and lifetime of ROS at low dose of DOXO, and overcame to GSH mediated drug resistance. The results also confirmed that SMF exposure decreased 50% iron content of cells, which is attributed to iron homeostasis. In conclusion, these findings suggest that SMF can decrease required dose of chemotherapy drugs such as DOXO and thereby decrease their side effect. |
| first_indexed | 2024-12-20T20:45:55Z |
| format | Article |
| id | doaj.art-6489c525ac754954b0a5ae1b524daccd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T20:45:55Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6489c525ac754954b0a5ae1b524daccd2022-12-21T19:27:03ZengNature PortfolioScientific Reports2045-23222018-01-018111210.1038/s41598-018-19247-8The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS BehaviorsBehnam Hajipour Verdom0Parviz Abdolmaleki1Mehrdad Behmanesh2Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University (TMU)Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University (TMU)Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University (TMU)Abstract Exposure to magnetic field (MF) can affect cellular metabolism remotely. Cardio-toxic effects of Doxorubicin (DOXO) have limited clinical uses at high dose. MF due to its effect on reactive oxygen species (ROS) lifetime, may provide a suitable choice to boost the efficacy of this drug at low dose. Here, we investigated the potential effects of homogenous static magnetic field (SMF) on DOXO-induced toxicity and proliferation rate of cancer cells. The results indicated that SMF similar to DOXO decreased the cell viability as well as the proliferation rate of MCF-7 and HFF cells. Moreover, combination of 10 mT SMF and 0.1 µM DOXO decreased the viability and proliferation rate of cancer and normal cells in a synergetic manner. In spite of high a GSH level in cancer cell, SMF boosts the generation and lifetime of ROS at low dose of DOXO, and overcame to GSH mediated drug resistance. The results also confirmed that SMF exposure decreased 50% iron content of cells, which is attributed to iron homeostasis. In conclusion, these findings suggest that SMF can decrease required dose of chemotherapy drugs such as DOXO and thereby decrease their side effect.https://doi.org/10.1038/s41598-018-19247-8 |
| spellingShingle | Behnam Hajipour Verdom Parviz Abdolmaleki Mehrdad Behmanesh The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors Scientific Reports |
| title | The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors |
| title_full | The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors |
| title_fullStr | The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors |
| title_full_unstemmed | The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors |
| title_short | The Static Magnetic Field Remotely Boosts the Efficiency of Doxorubicin through Modulating ROS Behaviors |
| title_sort | static magnetic field remotely boosts the efficiency of doxorubicin through modulating ros behaviors |
| url | https://doi.org/10.1038/s41598-018-19247-8 |
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