Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitals
Abstract Introduction Older adults are among the most vulnerable groups during the COVID-19 epidemic, contributing to a large proportion of COVID-19-related death. Medication review and reconciliation by pharmacist can help reduce the number of potentially inappropriate medications but these service...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-01-01
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| Series: | Journal of Pharmaceutical Policy and Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40545-022-00504-1 |
| _version_ | 1797329439810387968 |
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| author | Chee-Tao Chang Siti Mallissa Mohd Shariff Nur Suriana Abu Bakar Nasiha Sufina Ramzuzzaman Chun Kiat Lim Eddy Yew Joe Lim Peng Seng Ong Jie Min Lee Aie Yen Tan Siti Fatimah Kamis Wei Mun Liew Yuet Man Low Doris George James Yau Hon Voo Hoo Seng Tan Philip Rajan Shaun Wen Huey Lee |
| author_facet | Chee-Tao Chang Siti Mallissa Mohd Shariff Nur Suriana Abu Bakar Nasiha Sufina Ramzuzzaman Chun Kiat Lim Eddy Yew Joe Lim Peng Seng Ong Jie Min Lee Aie Yen Tan Siti Fatimah Kamis Wei Mun Liew Yuet Man Low Doris George James Yau Hon Voo Hoo Seng Tan Philip Rajan Shaun Wen Huey Lee |
| author_sort | Chee-Tao Chang |
| collection | DOAJ |
| description | Abstract Introduction Older adults are among the most vulnerable groups during the COVID-19 epidemic, contributing to a large proportion of COVID-19-related death. Medication review and reconciliation by pharmacist can help reduce the number of potentially inappropriate medications but these services were halted during COVID-19. Aim To assess the prevalence and factors associated with inappropriate medicine use among older populations with COVID-19. Methods This was a cross-sectional, retrospective analysis of medications among hospitalized older adults with COVID-19. Potentially inappropriate medication use was categorized using the Beer’s and STOPP criteria. Results Combining both criteria, 181 (32.7%) of the 553 patients were identified to have used at least one or more potentially inappropriate medication. A marginally higher number of inappropriate medications was documented using the Beers 2019 criteria (151 PIM in 124 patients) compared to STOPP criteria (133 PIMS in 104 patients). The long-term use of proton pump inhibitors (n = 68; 12.3%) and drugs which increases the risk of postural hypotension were the most commonly reported PIM (n = 41; 7.4%). Potentially inappropriate medication use was associated with previous history of hospital admission in the past 12 months (Odds ratio [OR]: 2.27; 95% CI 1.29–3.99) and higher number of discharge medications. Conclusions Nearly, one in three older adults with COVID-19 had been prescribed a PIM, and the proportion of older adults with polypharmacy increased after discharge. This highlights the importance of having clinical pharmacist conducting medication reviews to identify PIMs and ensure medication appropriateness. |
| first_indexed | 2024-03-08T07:05:44Z |
| format | Article |
| id | doaj.art-648d872fccdf40b7ae2707871a377cd2 |
| institution | Directory Open Access Journal |
| issn | 2052-3211 |
| language | English |
| last_indexed | 2024-03-08T07:05:44Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Pharmaceutical Policy and Practice |
| spelling | doaj.art-648d872fccdf40b7ae2707871a377cd22024-02-03T04:47:13ZengTaylor & Francis GroupJournal of Pharmaceutical Policy and Practice2052-32112023-01-011611610.1186/s40545-022-00504-1Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitalsChee-Tao Chang0Siti Mallissa Mohd Shariff1Nur Suriana Abu Bakar2Nasiha Sufina Ramzuzzaman3Chun Kiat Lim4Eddy Yew Joe Lim5Peng Seng Ong6Jie Min Lee7Aie Yen Tan8Siti Fatimah Kamis9Wei Mun Liew10Yuet Man Low11Doris George12James Yau Hon Voo13Hoo Seng Tan14Philip Rajan15Shaun Wen Huey Lee16Clinical Research Centre (CRC) HRPB Ipoh, Hospital Raja Permaisuri Bainun, Ministry of Health MalaysiaPharmacy Department, Hospital Sungai Buloh, Ministry of Health MalaysiaPharmacy Department, Hospital Sungai Buloh, Ministry of Health MalaysiaPharmacy Department, Hospital Sungai Buloh, Ministry of Health MalaysiaPharmacy Department, Hospital Sungai Buloh, Ministry of Health MalaysiaPharmacy Department, Hospital Sungai Buloh, Ministry of Health MalaysiaPharmacy Department, Hospital Pulau Pinang, Ministry of Health MalaysiaPharmacy Department, Hospital Pulau Pinang, Ministry of Health MalaysiaPharmacy Department, Hospital Sultan Ismail, Ministry of Health MalaysiaPharmacy Department, Hospital Sultan Ismail, Ministry of Health MalaysiaPharmacy Department, Hospital Raja Permaisuri Bainun, Ministry of Health MalaysiaPharmacy Department, Hospital Raja Permaisuri Bainun, Ministry of Health MalaysiaPharmacy Department, Hospital Raja Permaisuri Bainun, Ministry of Health MalaysiaPharmacy Department, Hospital Duchess of Kent, Ministry of Health MalaysiaPharmacy Department, Hospital Duchess of Kent, Ministry of Health MalaysiaClinical Research Centre (CRC) HRPB Ipoh, Hospital Raja Permaisuri Bainun, Ministry of Health MalaysiaSchool of Pharmacy, Monash University MalaysiaAbstract Introduction Older adults are among the most vulnerable groups during the COVID-19 epidemic, contributing to a large proportion of COVID-19-related death. Medication review and reconciliation by pharmacist can help reduce the number of potentially inappropriate medications but these services were halted during COVID-19. Aim To assess the prevalence and factors associated with inappropriate medicine use among older populations with COVID-19. Methods This was a cross-sectional, retrospective analysis of medications among hospitalized older adults with COVID-19. Potentially inappropriate medication use was categorized using the Beer’s and STOPP criteria. Results Combining both criteria, 181 (32.7%) of the 553 patients were identified to have used at least one or more potentially inappropriate medication. A marginally higher number of inappropriate medications was documented using the Beers 2019 criteria (151 PIM in 124 patients) compared to STOPP criteria (133 PIMS in 104 patients). The long-term use of proton pump inhibitors (n = 68; 12.3%) and drugs which increases the risk of postural hypotension were the most commonly reported PIM (n = 41; 7.4%). Potentially inappropriate medication use was associated with previous history of hospital admission in the past 12 months (Odds ratio [OR]: 2.27; 95% CI 1.29–3.99) and higher number of discharge medications. Conclusions Nearly, one in three older adults with COVID-19 had been prescribed a PIM, and the proportion of older adults with polypharmacy increased after discharge. This highlights the importance of having clinical pharmacist conducting medication reviews to identify PIMs and ensure medication appropriateness.https://doi.org/10.1186/s40545-022-00504-1PolypharmacyPotentially inappropriate medicationsHospitalOlder adultsCOVID-19Malaysia |
| spellingShingle | Chee-Tao Chang Siti Mallissa Mohd Shariff Nur Suriana Abu Bakar Nasiha Sufina Ramzuzzaman Chun Kiat Lim Eddy Yew Joe Lim Peng Seng Ong Jie Min Lee Aie Yen Tan Siti Fatimah Kamis Wei Mun Liew Yuet Man Low Doris George James Yau Hon Voo Hoo Seng Tan Philip Rajan Shaun Wen Huey Lee Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitals Journal of Pharmaceutical Policy and Practice Polypharmacy Potentially inappropriate medications Hospital Older adults COVID-19 Malaysia |
| title | Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitals |
| title_full | Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitals |
| title_fullStr | Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitals |
| title_full_unstemmed | Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitals |
| title_short | Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitals |
| title_sort | polypharmacy and potentially inappropriate medications among hospitalized older adults with covid 19 in malaysian tertiary hospitals |
| topic | Polypharmacy Potentially inappropriate medications Hospital Older adults COVID-19 Malaysia |
| url | https://doi.org/10.1186/s40545-022-00504-1 |
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