Recent Development on the Detection and Monitoring of Chemical Intermediates by Ambient Mass Spectrometry
Along with the development of science and technology, chemical reactions exhibit an important role in various fileds including synthesis, chemical engineering, energy, environment, biology and medicine. The effective intermediates monitoring and mechanism exploration of chemical reactions can promot...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Chinese Mass Spectrometry Society
2024-01-01
|
| Series: | Zhipu Xuebao |
| Subjects: | |
| Online Access: | https://zpxb.xml-journal.net/article/pdf/preview/67f47e48-9812-4772-9163-e2ef3129cf68 |
| _version_ | 1797324193911537664 |
|---|---|
| author | GE Xi-yang1 YIN Yi-yan1 OUYANG Jin2 NA Na1 |
| author_facet | GE Xi-yang1 YIN Yi-yan1 OUYANG Jin2 NA Na1 |
| author_sort | GE Xi-yang1 |
| collection | DOAJ |
| description | Along with the development of science and technology, chemical reactions exhibit an important role in various fileds including synthesis, chemical engineering, energy, environment, biology and medicine. The effective intermediates monitoring and mechanism exploration of chemical reactions can promote their development and contribute to the design of new chemical reactions. However, in the complex reaction matrix, a variety of intermediates with different molecular weights, life and dynamic changes will be generated at different reaction conditions, the effective capture and structure determinations of the short-lived and active reaction intermediates are hard to be achieved. In recent years, ambient mass spectrometry (AMS) has been widely used in the detection of chemical intermediates to explore reaction mechanisms, due to its advantages of high sensitivity, high selectivity, rapid analysis and in-situ monitoring. Herein, the research progress and development of AMS for the detection of reaction intermediates were reviewed, which involved the reactions in the fields of electrochemistry, photochemistry, plasma chemistry and microdroplet chemistry. For different types of reactions, the designs of different AMS detection technologies were introduced in details. Upon the different ionization strategies, different kinds of techniques have been reported, including desorption electrospray ionization mass spectrometry (DESI-MS), nano-electrospray ionization mass spectrometry (nESI-MS), extraction electrospray ionization mass spectrometry (EESI-MS), Venturi easy ambient sonic spray ionization mass spectrometry (VEASI-MS), spray-dependent plasma mass spectrometry (SDP-MS), accelerated plasma degradation coupled with electrospray ionization mass spectrometry (APD-MS), field-induced droplet ionization mass spectrometry (FIDI-MS) and so on. Subsequently, the progress and application of these mass spectrometry techniques in capturing intermediates of different kinds of reactions as well as the exploration of mechanisms were reviewed. Finally, the development of mass spectrometry for the detection of transient reaction intermediates in different chemical reactions, including electrochemical reactions, photochemical reactions, plasma reactions and microdroplet reactions were summarized and prospected. As reviewed, based on the characteristics of high throughput virtual screening and online monitoring, as well as the diversification of ion sources, AMS would be widely used in various fields including industrial production, environmental protection, energy and so on. In the future, the improved AMS techniques will be encouraged for examining more highly active intermediates with the increasing requirements for the examination of complicated reactions. |
| first_indexed | 2024-03-08T05:52:38Z |
| format | Article |
| id | doaj.art-648df2db72944ded9411b5ee3c0767b9 |
| institution | Directory Open Access Journal |
| issn | 1004-2997 |
| language | English |
| last_indexed | 2024-03-08T05:52:38Z |
| publishDate | 2024-01-01 |
| publisher | Editorial Board of Journal of Chinese Mass Spectrometry Society |
| record_format | Article |
| series | Zhipu Xuebao |
| spelling | doaj.art-648df2db72944ded9411b5ee3c0767b92024-02-05T08:35:28ZengEditorial Board of Journal of Chinese Mass Spectrometry SocietyZhipu Xuebao1004-29972024-01-014513143Recent Development on the Detection and Monitoring of Chemical Intermediates by Ambient Mass SpectrometryGE Xi-yang10YIN Yi-yan11OUYANG Jin22NA Na131. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China;2. Department of Chemistry, College of Arts and Sciences, Beijing Normal University at Zhuhai, Zhuhai 519087, China1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China;Along with the development of science and technology, chemical reactions exhibit an important role in various fileds including synthesis, chemical engineering, energy, environment, biology and medicine. The effective intermediates monitoring and mechanism exploration of chemical reactions can promote their development and contribute to the design of new chemical reactions. However, in the complex reaction matrix, a variety of intermediates with different molecular weights, life and dynamic changes will be generated at different reaction conditions, the effective capture and structure determinations of the short-lived and active reaction intermediates are hard to be achieved. In recent years, ambient mass spectrometry (AMS) has been widely used in the detection of chemical intermediates to explore reaction mechanisms, due to its advantages of high sensitivity, high selectivity, rapid analysis and in-situ monitoring. Herein, the research progress and development of AMS for the detection of reaction intermediates were reviewed, which involved the reactions in the fields of electrochemistry, photochemistry, plasma chemistry and microdroplet chemistry. For different types of reactions, the designs of different AMS detection technologies were introduced in details. Upon the different ionization strategies, different kinds of techniques have been reported, including desorption electrospray ionization mass spectrometry (DESI-MS), nano-electrospray ionization mass spectrometry (nESI-MS), extraction electrospray ionization mass spectrometry (EESI-MS), Venturi easy ambient sonic spray ionization mass spectrometry (VEASI-MS), spray-dependent plasma mass spectrometry (SDP-MS), accelerated plasma degradation coupled with electrospray ionization mass spectrometry (APD-MS), field-induced droplet ionization mass spectrometry (FIDI-MS) and so on. Subsequently, the progress and application of these mass spectrometry techniques in capturing intermediates of different kinds of reactions as well as the exploration of mechanisms were reviewed. Finally, the development of mass spectrometry for the detection of transient reaction intermediates in different chemical reactions, including electrochemical reactions, photochemical reactions, plasma reactions and microdroplet reactions were summarized and prospected. As reviewed, based on the characteristics of high throughput virtual screening and online monitoring, as well as the diversification of ion sources, AMS would be widely used in various fields including industrial production, environmental protection, energy and so on. In the future, the improved AMS techniques will be encouraged for examining more highly active intermediates with the increasing requirements for the examination of complicated reactions.https://zpxb.xml-journal.net/article/pdf/preview/67f47e48-9812-4772-9163-e2ef3129cf68• ambient mass spectrometry (ams)reaction intermediatesonline monitoringmechanism exploration |
| spellingShingle | GE Xi-yang1 YIN Yi-yan1 OUYANG Jin2 NA Na1 Recent Development on the Detection and Monitoring of Chemical Intermediates by Ambient Mass Spectrometry Zhipu Xuebao • ambient mass spectrometry (ams) reaction intermediates online monitoring mechanism exploration |
| title | Recent Development on the Detection and Monitoring of Chemical Intermediates by Ambient Mass Spectrometry |
| title_full | Recent Development on the Detection and Monitoring of Chemical Intermediates by Ambient Mass Spectrometry |
| title_fullStr | Recent Development on the Detection and Monitoring of Chemical Intermediates by Ambient Mass Spectrometry |
| title_full_unstemmed | Recent Development on the Detection and Monitoring of Chemical Intermediates by Ambient Mass Spectrometry |
| title_short | Recent Development on the Detection and Monitoring of Chemical Intermediates by Ambient Mass Spectrometry |
| title_sort | recent development on the detection and monitoring of chemical intermediates by ambient mass spectrometry |
| topic | • ambient mass spectrometry (ams) reaction intermediates online monitoring mechanism exploration |
| url | https://zpxb.xml-journal.net/article/pdf/preview/67f47e48-9812-4772-9163-e2ef3129cf68 |
| work_keys_str_mv | AT gexiyang1 recentdevelopmentonthedetectionandmonitoringofchemicalintermediatesbyambientmassspectrometry AT yinyiyan1 recentdevelopmentonthedetectionandmonitoringofchemicalintermediatesbyambientmassspectrometry AT ouyangjin2 recentdevelopmentonthedetectionandmonitoringofchemicalintermediatesbyambientmassspectrometry AT nana1 recentdevelopmentonthedetectionandmonitoringofchemicalintermediatesbyambientmassspectrometry |