Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study
Background: Proper management of depression in elderly population would improve the outcome of the disease and reduce its related disability and mortality. Use of memantine with minimal side effects and drug interaction seems reasonable in the elderly but its antidepressant activity is controversial...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2014;volume=19;issue=6;spage=525;epage=530;aulast=Omranifard |
| _version_ | 1811196069956026368 |
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| author | Victoria Omranifard Elham Shirzadi Saeid Samandari Hamid Afshar Mohammad Reza Maracy |
| author_facet | Victoria Omranifard Elham Shirzadi Saeid Samandari Hamid Afshar Mohammad Reza Maracy |
| author_sort | Victoria Omranifard |
| collection | DOAJ |
| description | Background: Proper management of depression in elderly population would improve the outcome of the disease and reduce its related disability and mortality. Use of memantine with minimal side effects and drug interaction seems reasonable in the elderly but its antidepressant activity is controversial. The aim of the current research is to investigate the effects of add-on memantine during citalopram therapy in elderly patients with depression, in Isfahan. Materials and Methods: In this double-blind, placebo controlled trial study; elderly patients aged more than 60 years who were recently diagnosed with depression, were enrolled. The selected patients were randomlysplit into two groups, viz. intervention and placebo groups. The intervention was memantine (20 mg daily) or identical placebo plus citalopram for 8 weeks. The severity of depression and quality of life was evaluated using Geriatric Depression Scale (GDS-15), Hamilton Rating Scale for depression (HRSD) and World Health Organization Quality of Life WHOQOL-BREF respectively. The mentioned scores were evaluated at baseline, 4 weeks and 8 weeks, after initiating the trial in two studied groups and compared with each other. Results: 28 and 29 patients were studied in the intervention and placebo groups, respectively. Score of GDS-15, HRSD and WHO-QOL-BREF scales at baseline, 4 weeks and 8 weeks, after initiating trial did not change significantly after use of memantine (P > 0.05). There was no significant difference in mean +/- SD of GDS-15, HRSD and WHO-QOL-BREF scales among intervention and placebo groups (P > 0.05). Conclusion: The outcome of this clinical trial did not support the antidepressant effect of add-on memantine in elderly patients with depression receiving citalopram. It is recommended to design further studies considering the limitations of the current study mentioned herein and the effect of memantine with other anti-depressant agents. |
| first_indexed | 2024-04-12T00:52:27Z |
| format | Article |
| id | doaj.art-648df5dc89a24f47a0d2ab7923dc9868 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-04-12T00:52:27Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-648df5dc89a24f47a0d2ab7923dc98682022-12-22T03:54:42ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362014-01-01196525530Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled studyVictoria OmranifardElham ShirzadiSaeid SamandariHamid AfsharMohammad Reza MaracyBackground: Proper management of depression in elderly population would improve the outcome of the disease and reduce its related disability and mortality. Use of memantine with minimal side effects and drug interaction seems reasonable in the elderly but its antidepressant activity is controversial. The aim of the current research is to investigate the effects of add-on memantine during citalopram therapy in elderly patients with depression, in Isfahan. Materials and Methods: In this double-blind, placebo controlled trial study; elderly patients aged more than 60 years who were recently diagnosed with depression, were enrolled. The selected patients were randomlysplit into two groups, viz. intervention and placebo groups. The intervention was memantine (20 mg daily) or identical placebo plus citalopram for 8 weeks. The severity of depression and quality of life was evaluated using Geriatric Depression Scale (GDS-15), Hamilton Rating Scale for depression (HRSD) and World Health Organization Quality of Life WHOQOL-BREF respectively. The mentioned scores were evaluated at baseline, 4 weeks and 8 weeks, after initiating the trial in two studied groups and compared with each other. Results: 28 and 29 patients were studied in the intervention and placebo groups, respectively. Score of GDS-15, HRSD and WHO-QOL-BREF scales at baseline, 4 weeks and 8 weeks, after initiating trial did not change significantly after use of memantine (P > 0.05). There was no significant difference in mean +/- SD of GDS-15, HRSD and WHO-QOL-BREF scales among intervention and placebo groups (P > 0.05). Conclusion: The outcome of this clinical trial did not support the antidepressant effect of add-on memantine in elderly patients with depression receiving citalopram. It is recommended to design further studies considering the limitations of the current study mentioned herein and the effect of memantine with other anti-depressant agents.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2014;volume=19;issue=6;spage=525;epage=530;aulast=OmranifardDepressiongeriatricmemantinequality of life |
| spellingShingle | Victoria Omranifard Elham Shirzadi Saeid Samandari Hamid Afshar Mohammad Reza Maracy Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study Journal of Research in Medical Sciences Depression geriatric memantine quality of life |
| title | Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study |
| title_full | Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study |
| title_fullStr | Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study |
| title_full_unstemmed | Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study |
| title_short | Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study |
| title_sort | memantine add on to citalopram in elderly patients with depression a double blind placebo controlled study |
| topic | Depression geriatric memantine quality of life |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2014;volume=19;issue=6;spage=525;epage=530;aulast=Omranifard |
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