The Methyl-CpG-binding domain (MBD) is crucial for MeCP2’s dysfunction-induced defects in adult newborn neurons

The Methyl-CpG-binding domain (MBD) is crucial for MeCP2’s dysfunction-induced defects in adult newborn neurons

Mutations in the human X-linked gene MECP2 are responsible for most Rett syndrome (RTT) cases, predominantly within its methyl-CpG-binding domain (MBD). To examine the role of MBD in the pathogenesis of RTT, we generated two MeCP2 mutant constructs, one with a deletion of MBD (MeCP2-ΔMBD), another...

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Bibliographic Details
Main Authors: Na eZhao, Dongliang eMa, Wan Ying eLeong, Ju eHan, Antonius eVanDongen, Teng eChen, Eyleen L Goh
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Dendrites
newborn neurons
Rett Syndrome (RTT)
spontaneuos Ca2+ oscillation
methyl-CpG binding protein 2 (MeCP2)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00158/full

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