Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survival
Introduction Testicular germ cell tumors with somatic‐type malignancy, wherein teratomas transform into sarcomas, is drug resistant and has a poor prognosis. Case presentation A 43‐year‐old man presented with a left testicular tumor, multiple pulmonary metastases, and mediastinal and para‐aortic lym...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | IJU Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iju5.12610 |
| _version_ | 1827825574598410240 |
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| author | Junji Kitamura Mitsuhiro Tambo Ayano Nishijima Kazuki Masuda Jimpei Miyakawa Yu Nakamura Masachika Fujiwara Takeshi Kishida Hiroyuki Ito Hiroshi Fukuhara |
| author_facet | Junji Kitamura Mitsuhiro Tambo Ayano Nishijima Kazuki Masuda Jimpei Miyakawa Yu Nakamura Masachika Fujiwara Takeshi Kishida Hiroyuki Ito Hiroshi Fukuhara |
| author_sort | Junji Kitamura |
| collection | DOAJ |
| description | Introduction Testicular germ cell tumors with somatic‐type malignancy, wherein teratomas transform into sarcomas, is drug resistant and has a poor prognosis. Case presentation A 43‐year‐old man presented with a left testicular tumor, multiple pulmonary metastases, and mediastinal and para‐aortic lymph node metastases. The testicular tumors were diagnosed as germ cell tumors. After bleomycin, etoposide, and cisplatin chemotherapy; right upper lobectomy for the pulmonary metastasis; and paclitaxel, ifosfamide, and cisplatin chemotherapy, rapidly progressing mediastinal lymph node metastasis was observed. It was resected at another specialized center owing to the challenging surgical approach. The histopathological diagnosis of the resected tumor was a teratoma with somatic‐type malignancy (rhabdomyosarcoma). Subsequently, left hilar lymph node metastasectomy and left upper lobectomy were performed for the pulmonary metastases. The patient survived for more than 8 years after initial treatment. Conclusion Surgery, although challenging, may yield long‐term survival for patients with testicular germ cell tumors with sarcomatous transformation. |
| first_indexed | 2024-03-12T02:51:17Z |
| format | Article |
| id | doaj.art-648f7e7ed8b943fcb4753fec11a4d7cb |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-03-12T02:51:17Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj.art-648f7e7ed8b943fcb4753fec11a4d7cb2023-09-04T00:11:48ZengWileyIJU Case Reports2577-171X2023-09-016530230510.1002/iju5.12610Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survivalJunji Kitamura0Mitsuhiro Tambo1Ayano Nishijima2Kazuki Masuda3Jimpei Miyakawa4Yu Nakamura5Masachika Fujiwara6Takeshi Kishida7Hiroyuki Ito8Hiroshi Fukuhara9Department of Urology Kyorin University School of Medicine Mitaka Tokyo JapanDepartment of Urology Kyorin University School of Medicine Mitaka Tokyo JapanDepartment of Urology Kyorin University School of Medicine Mitaka Tokyo JapanDepartment of Urology Kyorin University School of Medicine Mitaka Tokyo JapanDepartment of Urology Kyorin University School of Medicine Mitaka Tokyo JapanDepartment of Urology Kyorin University School of Medicine Mitaka Tokyo JapanDepartment of Pathology Kyorin University School of Medicine Mitaka Tokyo JapanDepartment of Urology Kanagawa Cancer Center Yokohama Kanagawa JapanDepartment of Thoracic Surgery Kanagawa Cancer Center Yokohama Kanagawa JapanDepartment of Urology Kyorin University School of Medicine Mitaka Tokyo JapanIntroduction Testicular germ cell tumors with somatic‐type malignancy, wherein teratomas transform into sarcomas, is drug resistant and has a poor prognosis. Case presentation A 43‐year‐old man presented with a left testicular tumor, multiple pulmonary metastases, and mediastinal and para‐aortic lymph node metastases. The testicular tumors were diagnosed as germ cell tumors. After bleomycin, etoposide, and cisplatin chemotherapy; right upper lobectomy for the pulmonary metastasis; and paclitaxel, ifosfamide, and cisplatin chemotherapy, rapidly progressing mediastinal lymph node metastasis was observed. It was resected at another specialized center owing to the challenging surgical approach. The histopathological diagnosis of the resected tumor was a teratoma with somatic‐type malignancy (rhabdomyosarcoma). Subsequently, left hilar lymph node metastasectomy and left upper lobectomy were performed for the pulmonary metastases. The patient survived for more than 8 years after initial treatment. Conclusion Surgery, although challenging, may yield long‐term survival for patients with testicular germ cell tumors with sarcomatous transformation.https://doi.org/10.1002/iju5.12610metastasisrhabdomyosarcomasurgeryteratomatesticular germ cell tumor |
| spellingShingle | Junji Kitamura Mitsuhiro Tambo Ayano Nishijima Kazuki Masuda Jimpei Miyakawa Yu Nakamura Masachika Fujiwara Takeshi Kishida Hiroyuki Ito Hiroshi Fukuhara Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survival IJU Case Reports metastasis rhabdomyosarcoma surgery teratoma testicular germ cell tumor |
| title | Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survival |
| title_full | Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survival |
| title_fullStr | Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survival |
| title_full_unstemmed | Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survival |
| title_short | Surgical resection in patient with teratoma with somatic‐type malignancy transformed into rhabdomyosarcoma resulted in long‐term survival |
| title_sort | surgical resection in patient with teratoma with somatic type malignancy transformed into rhabdomyosarcoma resulted in long term survival |
| topic | metastasis rhabdomyosarcoma surgery teratoma testicular germ cell tumor |
| url | https://doi.org/10.1002/iju5.12610 |
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