Comparison of the efficacy of microneedling combined with 5-fluorouracil 5% cream versus microneedling combined with tacrolimus 0.1% ointment in the treatment of vitiligo
Background and Design: Vitiligo is an acquired depigmenting disorder associated with profound psychological effects. It can manifest as depigmented macules that can be localized or generalized in nature. Various morphological types are seen in patients. Despite existing therapeutic options, none is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2022-06-01
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| Series: | Turkderm Turkish Archives of Dermatology and Venereology |
| Subjects: | |
| Online Access: | https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-57804&look4= |
| _version_ | 1797909027257057280 |
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| author | Parwaaz Matharoo Saurabh Sharma Jasleen Kaur Roopam Bassi |
| author_facet | Parwaaz Matharoo Saurabh Sharma Jasleen Kaur Roopam Bassi |
| author_sort | Parwaaz Matharoo |
| collection | DOAJ |
| description | Background and Design: Vitiligo is an acquired depigmenting disorder associated with profound psychological effects. It can manifest as depigmented macules that can be localized or generalized in nature. Various morphological types are seen in patients. Despite existing therapeutic options, none is yet proven to be an ideal method for all patients.
Materials and Methods: Sixty lesions in 30 patients with vitiligo were divided into two groups and subjected to microneedling with DermaPen after topical application of 5-fluorouracil (5-FU) cream 5% in one group and tacrolimus ointment 0.1% in another group. This procedure was repeated every 2 weeks for a maximum of 10 sessions. Patients were followed up for 6 months after the last session. Results: The overall repigmentation rate was significantly higher with 5-FU than with tacrolimus. Good-to-excellent response was seen in 76.7% of the lesions with 5-FU and 63.7% of the lesions with tacrolimus. Acral areas showed good-to-excellent response in 50% of the lesions in group A, and in group B, good response was seen in 50% lesions, whereas none attained excellent improvement. Conclusion: Microneedling with 5-FU and tacrolimus appears to be safe and effective therapeutic intervention for stable refractory vitiligo. Both combinations were tolerated well, but 5-FU demonstrated significantly quicker and higher response. |
| first_indexed | 2024-04-10T11:02:12Z |
| format | Article |
| id | doaj.art-648f8a7521e14817b8da6773f6fba554 |
| institution | Directory Open Access Journal |
| issn | 2651-5164 |
| language | English |
| last_indexed | 2024-04-10T11:02:12Z |
| publishDate | 2022-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkderm Turkish Archives of Dermatology and Venereology |
| spelling | doaj.art-648f8a7521e14817b8da6773f6fba5542023-02-15T16:19:36ZengGalenos Publishing HouseTurkderm Turkish Archives of Dermatology and Venereology2651-51642022-06-01562646910.4274/turkderm.galenos.2022.57804Comparison of the efficacy of microneedling combined with 5-fluorouracil 5% cream versus microneedling combined with tacrolimus 0.1% ointment in the treatment of vitiligoParwaaz Matharoo0https://orcid.org/0000-0003-0722-4659Saurabh Sharma1https://orcid.org/0000-0003-2808-136XJasleen Kaur2https://orcid.org/0000-0002-7428-1445Roopam Bassi3https://orcid.org/0000-0001-8600-0818Sri Guru Ram Das Institute of Medical Sciences and Research, Department of Dermatology, Venereology and Leprosy, Amritsar, IndiaSri Guru Ram Das Institute of Medical Sciences and Research, Department of Dermatology, Venereology and Leprosy, Amritsar, IndiaSri Guru Ram Das Institute of Medical Sciences and Research, Department of Dermatology, Venereology and Leprosy, Amritsar, IndiaSri Guru Ram Das Institute of Medical Sciences and Research, Department of Physiology, Amritsar, IndiaBackground and Design: Vitiligo is an acquired depigmenting disorder associated with profound psychological effects. It can manifest as depigmented macules that can be localized or generalized in nature. Various morphological types are seen in patients. Despite existing therapeutic options, none is yet proven to be an ideal method for all patients. Materials and Methods: Sixty lesions in 30 patients with vitiligo were divided into two groups and subjected to microneedling with DermaPen after topical application of 5-fluorouracil (5-FU) cream 5% in one group and tacrolimus ointment 0.1% in another group. This procedure was repeated every 2 weeks for a maximum of 10 sessions. Patients were followed up for 6 months after the last session. Results: The overall repigmentation rate was significantly higher with 5-FU than with tacrolimus. Good-to-excellent response was seen in 76.7% of the lesions with 5-FU and 63.7% of the lesions with tacrolimus. Acral areas showed good-to-excellent response in 50% of the lesions in group A, and in group B, good response was seen in 50% lesions, whereas none attained excellent improvement. Conclusion: Microneedling with 5-FU and tacrolimus appears to be safe and effective therapeutic intervention for stable refractory vitiligo. Both combinations were tolerated well, but 5-FU demonstrated significantly quicker and higher response.https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-57804&look4=fluorouraciltacrolimusvitiligo |
| spellingShingle | Parwaaz Matharoo Saurabh Sharma Jasleen Kaur Roopam Bassi Comparison of the efficacy of microneedling combined with 5-fluorouracil 5% cream versus microneedling combined with tacrolimus 0.1% ointment in the treatment of vitiligo Turkderm Turkish Archives of Dermatology and Venereology fluorouracil tacrolimus vitiligo |
| title | Comparison of the efficacy of microneedling combined with 5-fluorouracil 5% cream versus microneedling combined with tacrolimus 0.1% ointment in the treatment of vitiligo |
| title_full | Comparison of the efficacy of microneedling combined with 5-fluorouracil 5% cream versus microneedling combined with tacrolimus 0.1% ointment in the treatment of vitiligo |
| title_fullStr | Comparison of the efficacy of microneedling combined with 5-fluorouracil 5% cream versus microneedling combined with tacrolimus 0.1% ointment in the treatment of vitiligo |
| title_full_unstemmed | Comparison of the efficacy of microneedling combined with 5-fluorouracil 5% cream versus microneedling combined with tacrolimus 0.1% ointment in the treatment of vitiligo |
| title_short | Comparison of the efficacy of microneedling combined with 5-fluorouracil 5% cream versus microneedling combined with tacrolimus 0.1% ointment in the treatment of vitiligo |
| title_sort | comparison of the efficacy of microneedling combined with 5 fluorouracil 5 cream versus microneedling combined with tacrolimus 0 1 ointment in the treatment of vitiligo |
| topic | fluorouracil tacrolimus vitiligo |
| url | https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-57804&look4= |
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