Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis
To predict outcomes of tuberculosis we investigated the viability of Mycobacterium tuberculosis (MTB) in relation to drug resistance of strains and clinical manifestations of tuberculosis. During the study on solid Löwenstein - Jensen medium, we determined the speed, growth rate and drug resistance...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2017-09-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/437 |
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| author | E. Yu. Zorkaltseva O. A. Vorobyeva E. D. Savilov S. N. Shugaeva V. A. Astafyev |
| author_facet | E. Yu. Zorkaltseva O. A. Vorobyeva E. D. Savilov S. N. Shugaeva V. A. Astafyev |
| author_sort | E. Yu. Zorkaltseva |
| collection | DOAJ |
| description | To predict outcomes of tuberculosis we investigated the viability of Mycobacterium tuberculosis (MTB) in relation to drug resistance of strains and clinical manifestations of tuberculosis. During the study on solid Löwenstein - Jensen medium, we determined the speed, growth rate and drug resistance of MBT in 5945 cultures, isolated from the sputum of patients with pulmonary tuberculosis - residents of the Irkutsk region (2193 -from newly diagnosed patients, 3752 - from previously treated patients). The criterion of high viability of MBT was the growth rate of >100 colonies over < 30 days, average viability - < 100 colonies over > 20 days; and low viability corresponded with the growth rate of < 20 colonies over > 30 days. 2171 cultures (36.5 %) had high viability of MBT strains, 3021 (50.8 %) - low, and 753 (12.7 %) cultures had average degree of viability. A high degree of pathogen viability was more often determined in newly diagnosed patients with tuberculosis of intrathoracic lymph nodes (all patients with HIV-infection without antiretroviral therapy), fibrotic-cavernous and infiltrative tuberculosis. Among previously treated patients with tuberculosis the high viability of MBT was often determined in patients with fibrous-cavernous and infiltrative tuberculosis, and caseous pneumonia. Cultures from previously treated patients with tuberculosis of intrathoracic lymph nodes had low degree of viability. The number of drug-sensitive strains was 1992, drug-resistant ones - 3953, including 1430 strains with multidrug resistance. We have found that 37.5 % drug-resistant strains associated with a high degree of viability (multidrug resistance - 38.5 %), it's was more often than the drug-sensitive (35.4 %; p < 0.01). |
| first_indexed | 2024-03-08T12:17:59Z |
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| id | doaj.art-64903f7f5a5d4751b704b95b683bfb9a |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:18:08Z |
| publishDate | 2017-09-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-64903f7f5a5d4751b704b95b683bfb9a2024-03-28T07:49:18ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962017-09-0125(1)838710.12737/article_59e85cb69d5a04.82335815437Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosisE. Yu. Zorkaltseva0O. A. Vorobyeva1E. D. Savilov2S. N. Shugaeva3V. A. Astafyev4Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional EducationIrkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional EducationIrkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education; Scientific Centre for Family Health and Human Reproduction ProblemsIrkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional EducationIrkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional EducationTo predict outcomes of tuberculosis we investigated the viability of Mycobacterium tuberculosis (MTB) in relation to drug resistance of strains and clinical manifestations of tuberculosis. During the study on solid Löwenstein - Jensen medium, we determined the speed, growth rate and drug resistance of MBT in 5945 cultures, isolated from the sputum of patients with pulmonary tuberculosis - residents of the Irkutsk region (2193 -from newly diagnosed patients, 3752 - from previously treated patients). The criterion of high viability of MBT was the growth rate of >100 colonies over < 30 days, average viability - < 100 colonies over > 20 days; and low viability corresponded with the growth rate of < 20 colonies over > 30 days. 2171 cultures (36.5 %) had high viability of MBT strains, 3021 (50.8 %) - low, and 753 (12.7 %) cultures had average degree of viability. A high degree of pathogen viability was more often determined in newly diagnosed patients with tuberculosis of intrathoracic lymph nodes (all patients with HIV-infection without antiretroviral therapy), fibrotic-cavernous and infiltrative tuberculosis. Among previously treated patients with tuberculosis the high viability of MBT was often determined in patients with fibrous-cavernous and infiltrative tuberculosis, and caseous pneumonia. Cultures from previously treated patients with tuberculosis of intrathoracic lymph nodes had low degree of viability. The number of drug-sensitive strains was 1992, drug-resistant ones - 3953, including 1430 strains with multidrug resistance. We have found that 37.5 % drug-resistant strains associated with a high degree of viability (multidrug resistance - 38.5 %), it's was more often than the drug-sensitive (35.4 %; p < 0.01).https://www.actabiomedica.ru/jour/article/view/437tuberculosisthe viability of mycobacterium tuberculosisdrug resistancehiv-infection |
| spellingShingle | E. Yu. Zorkaltseva O. A. Vorobyeva E. D. Savilov S. N. Shugaeva V. A. Astafyev Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis Acta Biomedica Scientifica tuberculosis the viability of mycobacterium tuberculosis drug resistance hiv-infection |
| title | Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis |
| title_full | Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis |
| title_fullStr | Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis |
| title_full_unstemmed | Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis |
| title_short | Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis |
| title_sort | viability of causative pathogen in patients with drug sensitive and drug resistant forms of respiratory tuberculosis |
| topic | tuberculosis the viability of mycobacterium tuberculosis drug resistance hiv-infection |
| url | https://www.actabiomedica.ru/jour/article/view/437 |
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