Evaluación del comportamiento del perfil de lípidos postingesta de una carga lipídica estandarizada en jóvenes sanos, Universidad Nacional de Colombia, 2000
Backgrounds it has been shown that high levels of cholesterol and triglycerides besides low levels of HDL cholesterol are associated with higher risk of atherosclerosis and its consequences. The exaggerated elevation in triglycerides after a meal is an alteration that has raised concern in the last...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2001-07-01
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| Series: | Revista de la Facultad de Medicina |
| Subjects: | |
| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/19757 |
| _version_ | 1811217147117961216 |
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| author | Iván D. Sierra Clara Pérez Olimpo Mendivil Giuliana Pinzón Gerardo Mantilla Alvaro Gámez Emilio Fernández-Britto Luisa F. Bohórquez |
| author_facet | Iván D. Sierra Clara Pérez Olimpo Mendivil Giuliana Pinzón Gerardo Mantilla Alvaro Gámez Emilio Fernández-Britto Luisa F. Bohórquez |
| author_sort | Iván D. Sierra |
| collection | DOAJ |
| description | Backgrounds it has been shown that high levels of cholesterol and triglycerides besides low levels of HDL cholesterol are associated with higher risk of atherosclerosis and its consequences. The exaggerated elevation in triglycerides after a meal is an alteration that has raised concern in the last years. However, there isn't still a normality threshold for its behavior according to the findings in normal subjects Methods: We analyzed the variation in HDL cholesterol and triglycerides in a sample of 50 healthy individuals (25 men and 25 women), after intake of a test breakfast, regarding for the postprandial pattern for these parameters, specially the hour in which the maximum value of triglycerides was shown in the normal population and the value that could discriminate between healthy individuals and those with postprandial hiperlipemia. Results: We found a great variability in the postprandial behavior of triglycerides among individuals, specially in men. The greater percentage of individuals showed the maximum of triglycerides in the third postprandial hour. However the differences between men and women were not statistically significant The HDL cholesterol had only slight variations along the study, and they were not statistically significant. It wasn't possible to establish correlations among the HDL and triglyceride levels and the secondary measures relative to health condition, existing very low correlation levels. The trygliceride value in the second, third and fourth hour presented a high correlation. Conclusions: Our results show a similar behavior in postprandiallipemia in men and women. The greater elevation of triglyceride levels between second and fourth hour in 81,1 % of the patients allows us to suppose that a value obtained in this time interval is representative of postprandiallipids for an important part of the population. The behavior of HDL cholesterol seem not to show significative variations along the postprandial period, although it shows a small decline of 5% in the third hour, coincidentally with the greater elevation of triglycerides. If we want to use these findings to draw normal values that allow to discrimina te a normal pattern from a pathologic one, further studies will be needed gathering clearly iII populations and comparing their findings with those shown here. |
| first_indexed | 2024-04-12T06:50:19Z |
| format | Article |
| id | doaj.art-649210eb454447a2a6c213c520b8c93e |
| institution | Directory Open Access Journal |
| issn | 0120-0011 2357-3848 |
| language | English |
| last_indexed | 2024-04-12T06:50:19Z |
| publishDate | 2001-07-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista de la Facultad de Medicina |
| spelling | doaj.art-649210eb454447a2a6c213c520b8c93e2022-12-22T03:43:24ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482001-07-0149314114617988Evaluación del comportamiento del perfil de lípidos postingesta de una carga lipídica estandarizada en jóvenes sanos, Universidad Nacional de Colombia, 2000Iván D. SierraClara PérezOlimpo MendivilGiuliana PinzónGerardo MantillaAlvaro GámezEmilio Fernández-BrittoLuisa F. BohórquezBackgrounds it has been shown that high levels of cholesterol and triglycerides besides low levels of HDL cholesterol are associated with higher risk of atherosclerosis and its consequences. The exaggerated elevation in triglycerides after a meal is an alteration that has raised concern in the last years. However, there isn't still a normality threshold for its behavior according to the findings in normal subjects Methods: We analyzed the variation in HDL cholesterol and triglycerides in a sample of 50 healthy individuals (25 men and 25 women), after intake of a test breakfast, regarding for the postprandial pattern for these parameters, specially the hour in which the maximum value of triglycerides was shown in the normal population and the value that could discriminate between healthy individuals and those with postprandial hiperlipemia. Results: We found a great variability in the postprandial behavior of triglycerides among individuals, specially in men. The greater percentage of individuals showed the maximum of triglycerides in the third postprandial hour. However the differences between men and women were not statistically significant The HDL cholesterol had only slight variations along the study, and they were not statistically significant. It wasn't possible to establish correlations among the HDL and triglyceride levels and the secondary measures relative to health condition, existing very low correlation levels. The trygliceride value in the second, third and fourth hour presented a high correlation. Conclusions: Our results show a similar behavior in postprandiallipemia in men and women. The greater elevation of triglyceride levels between second and fourth hour in 81,1 % of the patients allows us to suppose that a value obtained in this time interval is representative of postprandiallipids for an important part of the population. The behavior of HDL cholesterol seem not to show significative variations along the postprandial period, although it shows a small decline of 5% in the third hour, coincidentally with the greater elevation of triglycerides. If we want to use these findings to draw normal values that allow to discrimina te a normal pattern from a pathologic one, further studies will be needed gathering clearly iII populations and comparing their findings with those shown here.https://revistas.unal.edu.co/index.php/revfacmed/article/view/19757colesterol HDLtriglicéridosdientametabolismo |
| spellingShingle | Iván D. Sierra Clara Pérez Olimpo Mendivil Giuliana Pinzón Gerardo Mantilla Alvaro Gámez Emilio Fernández-Britto Luisa F. Bohórquez Evaluación del comportamiento del perfil de lípidos postingesta de una carga lipídica estandarizada en jóvenes sanos, Universidad Nacional de Colombia, 2000 Revista de la Facultad de Medicina colesterol HDL triglicéridos dienta metabolismo |
| title | Evaluación del comportamiento del perfil de lípidos postingesta de una carga lipídica estandarizada en jóvenes sanos, Universidad Nacional de Colombia, 2000 |
| title_full | Evaluación del comportamiento del perfil de lípidos postingesta de una carga lipídica estandarizada en jóvenes sanos, Universidad Nacional de Colombia, 2000 |
| title_fullStr | Evaluación del comportamiento del perfil de lípidos postingesta de una carga lipídica estandarizada en jóvenes sanos, Universidad Nacional de Colombia, 2000 |
| title_full_unstemmed | Evaluación del comportamiento del perfil de lípidos postingesta de una carga lipídica estandarizada en jóvenes sanos, Universidad Nacional de Colombia, 2000 |
| title_short | Evaluación del comportamiento del perfil de lípidos postingesta de una carga lipídica estandarizada en jóvenes sanos, Universidad Nacional de Colombia, 2000 |
| title_sort | evaluacion del comportamiento del perfil de lipidos postingesta de una carga lipidica estandarizada en jovenes sanos universidad nacional de colombia 2000 |
| topic | colesterol HDL triglicéridos dienta metabolismo |
| url | https://revistas.unal.edu.co/index.php/revfacmed/article/view/19757 |
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