Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles
Bacteria-host interaction is a common, relevant, and intriguing biological phenomena. The host reacts actively or passively to the bacteria themselves, their products, debris, and so on, through various defense systems containing the immune system, the bacteria communicate with the local or distal t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1225513/full |
| _version_ | 1827855335937802240 |
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| author | Min Xiao Min Xiao Guiding Li Guiding Li Hefeng Yang Hefeng Yang |
| author_facet | Min Xiao Min Xiao Guiding Li Guiding Li Hefeng Yang Hefeng Yang |
| author_sort | Min Xiao |
| collection | DOAJ |
| description | Bacteria-host interaction is a common, relevant, and intriguing biological phenomena. The host reacts actively or passively to the bacteria themselves, their products, debris, and so on, through various defense systems containing the immune system, the bacteria communicate with the local or distal tissues of the host via their own surface antigens, secreted products, nucleic acids, etc., resulting in relationships of attack and defense, adaptation, symbiosis, and even collaboration. The significance of bacterial membrane vesicles (MVs) as a powerful vehicle for the crosstalk mechanism between the two is growing. In the recent decade, the emergence of MVs in microbial interactions and a variety of bacterial infections, with multiple adhesions to host tissues, cell invasion and evasion of host defense mechanisms, have brought MVs to the forefront of bacterial pathogenesis research. Whereas MVs are a complex combination of molecules not yet fully understood, research into its effects, targeting and pathogenic components will advance its understanding and utilization. This review will summarize structural, extraction and penetration information on several classes of MVs and emphasize the role of MVs in transport and immune response activation. Finally, the potential of MVs as a therapeutic method will be highlighted, as will future research prospects. |
| first_indexed | 2024-03-12T11:49:40Z |
| format | Article |
| id | doaj.art-64938492bb984101af6009288f8f81c6 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-12T11:49:40Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-64938492bb984101af6009288f8f81c62023-08-31T11:09:59ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-08-011410.3389/fmicb.2023.12255131225513Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesiclesMin Xiao0Min Xiao1Guiding Li2Guiding Li3Hefeng Yang4Hefeng Yang5Yunnan Key Laboratory of Stomatology, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Dental Research, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, ChinaYunnan Key Laboratory of Stomatology, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Dental Research, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, ChinaYunnan Key Laboratory of Stomatology, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Dental Research, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, ChinaBacteria-host interaction is a common, relevant, and intriguing biological phenomena. The host reacts actively or passively to the bacteria themselves, their products, debris, and so on, through various defense systems containing the immune system, the bacteria communicate with the local or distal tissues of the host via their own surface antigens, secreted products, nucleic acids, etc., resulting in relationships of attack and defense, adaptation, symbiosis, and even collaboration. The significance of bacterial membrane vesicles (MVs) as a powerful vehicle for the crosstalk mechanism between the two is growing. In the recent decade, the emergence of MVs in microbial interactions and a variety of bacterial infections, with multiple adhesions to host tissues, cell invasion and evasion of host defense mechanisms, have brought MVs to the forefront of bacterial pathogenesis research. Whereas MVs are a complex combination of molecules not yet fully understood, research into its effects, targeting and pathogenic components will advance its understanding and utilization. This review will summarize structural, extraction and penetration information on several classes of MVs and emphasize the role of MVs in transport and immune response activation. Finally, the potential of MVs as a therapeutic method will be highlighted, as will future research prospects.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1225513/fullGram-negativemembrane vesiclesinteractionsimmune responseapplication |
| spellingShingle | Min Xiao Min Xiao Guiding Li Guiding Li Hefeng Yang Hefeng Yang Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles Frontiers in Microbiology Gram-negative membrane vesicles interactions immune response application |
| title | Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles |
| title_full | Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles |
| title_fullStr | Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles |
| title_full_unstemmed | Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles |
| title_short | Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles |
| title_sort | microbe host interactions structure and functions of gram negative bacterial membrane vesicles |
| topic | Gram-negative membrane vesicles interactions immune response application |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1225513/full |
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