Prognostic value of hypoxia-inducible factor-1 alpha gene polymorphism in patients with heart failure with preserved ejection fraction and obstructive sleep apnea
Aim. To study the associations of hypoxia-inducible factor-1 alpha (HIF-1α) gene polymorphism (rs11549465) with the clinical course of heart failure (HF) with reserved ejection fraction (HFpEF) in patients with obesity and moderate and severe obstructive sleep apnea (OSA).Material and methods. The s...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2022-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3276 |
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| author | A. V. Yakovlev R. S. Chernyshev K. S. Sakhonchik S. N. Shilov E. V. Grakova K. V. Kop’eva A. T. Teplyakov I. A. Efremov M. S. Kessler N. F. Yakovleva I. A. Grebenkina |
| author_facet | A. V. Yakovlev R. S. Chernyshev K. S. Sakhonchik S. N. Shilov E. V. Grakova K. V. Kop’eva A. T. Teplyakov I. A. Efremov M. S. Kessler N. F. Yakovleva I. A. Grebenkina |
| author_sort | A. V. Yakovlev |
| collection | DOAJ |
| description | Aim. To study the associations of hypoxia-inducible factor-1 alpha (HIF-1α) gene polymorphism (rs11549465) with the clinical course of heart failure (HF) with reserved ejection fraction (HFpEF) in patients with obesity and moderate and severe obstructive sleep apnea (OSA).Material and methods. The study included 76 men with HFpEF and OSAS. Patients underwent a polysomnography, echocardiography, and a 6-minute walk test. In addition, apnea/hypopnea index was calculated, and the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) was assessed. HIF1A gene polymorphisms (rs11549465) were analyzed using polymerase chain reaction. After 12-month follow-up, the clinical course of HF was assessed.Results. The T/T genotype of the HIF1A gene was associated with a high risk of HF progression (p=0,004), development of supraventricular premature beats (p=0,004) and atrial fibrillation (p=0,039). Carrying the T/T genotype was associated with severe OSA (p=0,006) and increased NT-proBNP (p=0,044), and also correlated with certain echocardiographic characteristics of myocardial remodeling.Conclusion. T/T genotype of the HIF1A gene is associated with OSA severity and increased NT-proBNP, as well as with the severity of left and right heart remodeling. The carriage of this genotype was associated with an unfavorable course of HF and an increased risk of atrial fibrillation in patients with HFpEF and OSA. |
| first_indexed | 2024-04-10T03:34:02Z |
| format | Article |
| id | doaj.art-64941ec9d2294fd0a3c947e56c1f7dfb |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:34:02Z |
| publishDate | 2022-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-64941ec9d2294fd0a3c947e56c1f7dfb2023-03-13T07:23:32Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252022-08-0121710.15829/1728-8800-2022-32762505Prognostic value of hypoxia-inducible factor-1 alpha gene polymorphism in patients with heart failure with preserved ejection fraction and obstructive sleep apneaA. V. Yakovlev0R. S. Chernyshev1K. S. Sakhonchik2S. N. Shilov3E. V. Grakova4K. V. Kop’eva5A. T. Teplyakov6I. A. Efremov7M. S. Kessler8N. F. Yakovleva9I. A. Grebenkina10Новосибирский государственный медицинский университет Минздрава РоссииНовосибирский государственный медицинский университет Минздрава РоссииНовосибирский государственный медицинский университет Минздрава РоссииНовосибирский государственный медицинский университет Минздрава РоссииНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наукНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наукНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наукНовосибирский государственный медицинский университет Минздрава РоссииНовосибирский государственный медицинский университет Минздрава РоссииНовосибирский государственный медицинский университет Минздрава РоссииНовосибирский государственный медицинский университет Минздрава РоссииAim. To study the associations of hypoxia-inducible factor-1 alpha (HIF-1α) gene polymorphism (rs11549465) with the clinical course of heart failure (HF) with reserved ejection fraction (HFpEF) in patients with obesity and moderate and severe obstructive sleep apnea (OSA).Material and methods. The study included 76 men with HFpEF and OSAS. Patients underwent a polysomnography, echocardiography, and a 6-minute walk test. In addition, apnea/hypopnea index was calculated, and the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) was assessed. HIF1A gene polymorphisms (rs11549465) were analyzed using polymerase chain reaction. After 12-month follow-up, the clinical course of HF was assessed.Results. The T/T genotype of the HIF1A gene was associated with a high risk of HF progression (p=0,004), development of supraventricular premature beats (p=0,004) and atrial fibrillation (p=0,039). Carrying the T/T genotype was associated with severe OSA (p=0,006) and increased NT-proBNP (p=0,044), and also correlated with certain echocardiographic characteristics of myocardial remodeling.Conclusion. T/T genotype of the HIF1A gene is associated with OSA severity and increased NT-proBNP, as well as with the severity of left and right heart remodeling. The carriage of this genotype was associated with an unfavorable course of HF and an increased risk of atrial fibrillation in patients with HFpEF and OSA.https://cardiovascular.elpub.ru/jour/article/view/3276полиморфизм<i>hif1a</i>hif-1αхроническая сердечная недостаточностьсиндром обструктивного апноэгенотиппрогноз |
| spellingShingle | A. V. Yakovlev R. S. Chernyshev K. S. Sakhonchik S. N. Shilov E. V. Grakova K. V. Kop’eva A. T. Teplyakov I. A. Efremov M. S. Kessler N. F. Yakovleva I. A. Grebenkina Prognostic value of hypoxia-inducible factor-1 alpha gene polymorphism in patients with heart failure with preserved ejection fraction and obstructive sleep apnea Кардиоваскулярная терапия и профилактика полиморфизм <i>hif1a</i> hif-1α хроническая сердечная недостаточность синдром обструктивного апноэ генотип прогноз |
| title | Prognostic value of hypoxia-inducible factor-1 alpha gene polymorphism in patients with heart failure with preserved ejection fraction and obstructive sleep apnea |
| title_full | Prognostic value of hypoxia-inducible factor-1 alpha gene polymorphism in patients with heart failure with preserved ejection fraction and obstructive sleep apnea |
| title_fullStr | Prognostic value of hypoxia-inducible factor-1 alpha gene polymorphism in patients with heart failure with preserved ejection fraction and obstructive sleep apnea |
| title_full_unstemmed | Prognostic value of hypoxia-inducible factor-1 alpha gene polymorphism in patients with heart failure with preserved ejection fraction and obstructive sleep apnea |
| title_short | Prognostic value of hypoxia-inducible factor-1 alpha gene polymorphism in patients with heart failure with preserved ejection fraction and obstructive sleep apnea |
| title_sort | prognostic value of hypoxia inducible factor 1 alpha gene polymorphism in patients with heart failure with preserved ejection fraction and obstructive sleep apnea |
| topic | полиморфизм <i>hif1a</i> hif-1α хроническая сердечная недостаточность синдром обструктивного апноэ генотип прогноз |
| url | https://cardiovascular.elpub.ru/jour/article/view/3276 |
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