The role of host molecules in communication with the resident and pathogenic microbiota: A review
The human body harbours around 100 trillion microbial cells within a network of complex ecosytems. There is now a well-established correlation between microbes and health in conditions associated with chronic inflammation, and much research has focused on the microbe-to-human axis of communication....
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-06-01
|
| Series: | Medicine in Microecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590097820300021 |
| _version_ | 1818381821862215680 |
|---|---|
| author | Joni Renee White Priscila Dauros-Singorenko Jiwon Hong Frédérique Vanholsbeeck Anthony Phillips Simon Swift |
| author_facet | Joni Renee White Priscila Dauros-Singorenko Jiwon Hong Frédérique Vanholsbeeck Anthony Phillips Simon Swift |
| author_sort | Joni Renee White |
| collection | DOAJ |
| description | The human body harbours around 100 trillion microbial cells within a network of complex ecosytems. There is now a well-established correlation between microbes and health in conditions associated with chronic inflammation, and much research has focused on the microbe-to-human axis of communication. At a molecular level, the particular microbial activities and functions that dictate a “healthy” microbiota remain enigmatic. However, evidence from human and animal studies suggests that the host exercises control over the composition of microbial populations through the tightly regulated production and release of hormones, metabolites, nucleic acids, and immune effectors like cytokines. Many of these molecules are taken up by, or bind directly to, microbial cells, and it has been proposed that extracellular vesicles may help to carry these molecules directly to bacteria for enhanced uptake. Understanding how host control of the microbiota may become dysregulated in disease states will lead to novel ways of treating diseases and symptoms. Here we review the evidence for host regulation of the resident and pathogenic microbiota, with a focus on molecular mechanisms of communication in health and disease, and pinpoint how this knowledge may benefit future therapeutics. |
| first_indexed | 2024-12-14T02:40:40Z |
| format | Article |
| id | doaj.art-64943fb66a814996a1ce9ac9e5aece26 |
| institution | Directory Open Access Journal |
| issn | 2590-0978 |
| language | English |
| last_indexed | 2024-12-14T02:40:40Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Microecology |
| spelling | doaj.art-64943fb66a814996a1ce9ac9e5aece262022-12-21T23:20:01ZengElsevierMedicine in Microecology2590-09782020-06-014100005The role of host molecules in communication with the resident and pathogenic microbiota: A reviewJoni Renee White0Priscila Dauros-Singorenko1Jiwon Hong2Frédérique Vanholsbeeck3Anthony Phillips4Simon Swift5Department of Molecular Medicine and Pathology, 85 Park Road, The University of Auckland, Auckland, New Zealand; The Dodd-Walls Centre for Photonic and Quantum Technologies, New Zealand; Corresponding author. Department of Molecular Medicine & Pathology, 85 Park Road, Auckland, 1023, New Zealand.Department of Molecular Medicine and Pathology, 85 Park Road, The University of Auckland, Auckland, New Zealand; Department of Surgery, 2 Park Road, The University of Auckland, Auckland, New ZealandDepartment of Surgery, 2 Park Road, The University of Auckland, Auckland, New Zealand; School of Biological Sciences, 3A Symonds Street, The University of Auckland, Auckland, New Zealand; Surgical and Translational Research Centre, The University of Auckland, Auckland, New ZealandThe Dodd-Walls Centre for Photonic and Quantum Technologies, New Zealand; Department of Physics, 38 Princes Street, The University of Auckland, Auckland, New ZealandDepartment of Surgery, 2 Park Road, The University of Auckland, Auckland, New Zealand; School of Biological Sciences, 3A Symonds Street, The University of Auckland, Auckland, New Zealand; Surgical and Translational Research Centre, The University of Auckland, Auckland, New ZealandDepartment of Molecular Medicine and Pathology, 85 Park Road, The University of Auckland, Auckland, New ZealandThe human body harbours around 100 trillion microbial cells within a network of complex ecosytems. There is now a well-established correlation between microbes and health in conditions associated with chronic inflammation, and much research has focused on the microbe-to-human axis of communication. At a molecular level, the particular microbial activities and functions that dictate a “healthy” microbiota remain enigmatic. However, evidence from human and animal studies suggests that the host exercises control over the composition of microbial populations through the tightly regulated production and release of hormones, metabolites, nucleic acids, and immune effectors like cytokines. Many of these molecules are taken up by, or bind directly to, microbial cells, and it has been proposed that extracellular vesicles may help to carry these molecules directly to bacteria for enhanced uptake. Understanding how host control of the microbiota may become dysregulated in disease states will lead to novel ways of treating diseases and symptoms. Here we review the evidence for host regulation of the resident and pathogenic microbiota, with a focus on molecular mechanisms of communication in health and disease, and pinpoint how this knowledge may benefit future therapeutics.http://www.sciencedirect.com/science/article/pii/S2590097820300021MicrobiotaCross-kingdom communicationExtracellular vesiclesDysbiosis |
| spellingShingle | Joni Renee White Priscila Dauros-Singorenko Jiwon Hong Frédérique Vanholsbeeck Anthony Phillips Simon Swift The role of host molecules in communication with the resident and pathogenic microbiota: A review Medicine in Microecology Microbiota Cross-kingdom communication Extracellular vesicles Dysbiosis |
| title | The role of host molecules in communication with the resident and pathogenic microbiota: A review |
| title_full | The role of host molecules in communication with the resident and pathogenic microbiota: A review |
| title_fullStr | The role of host molecules in communication with the resident and pathogenic microbiota: A review |
| title_full_unstemmed | The role of host molecules in communication with the resident and pathogenic microbiota: A review |
| title_short | The role of host molecules in communication with the resident and pathogenic microbiota: A review |
| title_sort | role of host molecules in communication with the resident and pathogenic microbiota a review |
| topic | Microbiota Cross-kingdom communication Extracellular vesicles Dysbiosis |
| url | http://www.sciencedirect.com/science/article/pii/S2590097820300021 |
| work_keys_str_mv | AT jonireneewhite theroleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT prisciladaurossingorenko theroleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT jiwonhong theroleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT frederiquevanholsbeeck theroleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT anthonyphillips theroleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT simonswift theroleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT jonireneewhite roleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT prisciladaurossingorenko roleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT jiwonhong roleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT frederiquevanholsbeeck roleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT anthonyphillips roleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview AT simonswift roleofhostmoleculesincommunicationwiththeresidentandpathogenicmicrobiotaareview |