Impact of Neoadjuvant Bevacizumab on Neuroradiographic Response and Histological Findings Related to Tumor Stemness and the Hypoxic Tumor Microenvironment in Glioblastoma: Paired Comparison Between Newly Diagnosed and Recurrent Glioblastomas

Impact of Neoadjuvant Bevacizumab on Neuroradiographic Response and Histological Findings Related to Tumor Stemness and the Hypoxic Tumor Microenvironment in Glioblastoma: Paired Comparison Between Newly Diagnosed and Recurrent Glioblastomas

BackgroundPreviously, we reported that bevacizumab (Bev) produces histological and neuroradiographic alterations including changes in tumor oxygenation, induction of an immunosupportive tumor microenvironment, and inhibition of stemness. To confirm how those effects vary during Bev therapy, paired s...

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Bibliographic Details
Main Authors: Jun Takei, Nei Fukasawa, Toshihide Tanaka, Yohei Yamamoto, Ryota Tamura, Hikaru Sasaki, Yasuharu Akasaki, Yuko Kamata, Mutsunori Murahashi, Masayuki Shimoda, Yuichi Murayama
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
bevacizumab
glioblastoma
FOXM1
magnetic resonance imaging (MRI)
tumor microenvironment
pseudo-papillary structure
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.898614/full

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