Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial
This study aims to evaluate efficacy and safety of Nigella sativa oil supplementation in patients with chronic kidney disease Stage 3 and 4 due to diabetic nephropathy. It was a prospective, comparative, and open-label study. Patients were randomized into two groups. Group 1 (Control) received conse...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=1;spage=9;epage=14;aulast=Ansari |
| _version_ | 1818254709793751040 |
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| author | Zafar Masood Ansari Mohammad Nasiruddin Rahat Ali Khan Shahzad Faizul Haque |
| author_facet | Zafar Masood Ansari Mohammad Nasiruddin Rahat Ali Khan Shahzad Faizul Haque |
| author_sort | Zafar Masood Ansari |
| collection | DOAJ |
| description | This study aims to evaluate efficacy and safety of Nigella sativa oil supplementation in patients with chronic kidney disease Stage 3 and 4 due to diabetic nephropathy. It was a prospective, comparative, and open-label study. Patients were randomized into two groups. Group 1 (Control) received conservative management of diabetic nephropathy, whereas Group 2 (Test) received N. sativa oil (2.5 mL, once daily and per orally) along with conservative management for 12 weeks. Blood glucose, hemogram, and kidney function test were done at 0, 6, and 12 weeks of treatment. Significance of differences between pre- and post-treatment values in each group was assessed using Student′s paired t-test and between the groups using unpaired t-test. We found a drop in blood glucose, serum creatinine, blood urea, and 24 h total urinary protein levels and a rise in glomerular filtration rate, 24 h total urinary volume, and hemoglobin level in the treatment group compared to the control group. |
| first_indexed | 2024-12-12T17:00:17Z |
| format | Article |
| id | doaj.art-6499dca5eb3f408db232ff75a24dbf3a |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-12T17:00:17Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-6499dca5eb3f408db232ff75a24dbf3a2022-12-22T00:18:09ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422017-01-0128191410.4103/1319-2442.198093Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trialZafar Masood AnsariMohammad NasiruddinRahat Ali KhanShahzad Faizul HaqueThis study aims to evaluate efficacy and safety of Nigella sativa oil supplementation in patients with chronic kidney disease Stage 3 and 4 due to diabetic nephropathy. It was a prospective, comparative, and open-label study. Patients were randomized into two groups. Group 1 (Control) received conservative management of diabetic nephropathy, whereas Group 2 (Test) received N. sativa oil (2.5 mL, once daily and per orally) along with conservative management for 12 weeks. Blood glucose, hemogram, and kidney function test were done at 0, 6, and 12 weeks of treatment. Significance of differences between pre- and post-treatment values in each group was assessed using Student′s paired t-test and between the groups using unpaired t-test. We found a drop in blood glucose, serum creatinine, blood urea, and 24 h total urinary protein levels and a rise in glomerular filtration rate, 24 h total urinary volume, and hemoglobin level in the treatment group compared to the control group.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=1;spage=9;epage=14;aulast=Ansari |
| spellingShingle | Zafar Masood Ansari Mohammad Nasiruddin Rahat Ali Khan Shahzad Faizul Haque Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial Saudi Journal of Kidney Diseases and Transplantation |
| title | Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial |
| title_full | Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial |
| title_fullStr | Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial |
| title_full_unstemmed | Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial |
| title_short | Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial |
| title_sort | protective role of nigella sativa in diabetic nephropathy a randomized clinical trial |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=1;spage=9;epage=14;aulast=Ansari |
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