WAYS OF IMPROVEMENT OF PHARMACOTHERAPY OF EPILEPSY AT CHILDREN: FOCUS ON SPECIFIC FEATURES OF BIOTRANSFORMATION MEDICINES
For the first time at children of five various nationalities living in the territory of the Astrakhan region, polymorphism of a gene of CYP2C19 on a polymorphic marker of G681A is studied. Statistically authentic distinction in frequencies of occurrence of genotypes of CYP2C19 associated both with f...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IRBIS LLC
2016-09-01
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| Series: | Эпилепсия и пароксизмальные состояния |
| Subjects: | |
| Online Access: | https://www.epilepsia.su/jour/article/view/268 |
| _version_ | 1797879446691119104 |
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| author | B. I. Kantemirova A. K. Starodubtsev D. A. Sychev V. V. Belopasov Zh. M. Tsotsonava V. I. Griganov |
| author_facet | B. I. Kantemirova A. K. Starodubtsev D. A. Sychev V. V. Belopasov Zh. M. Tsotsonava V. I. Griganov |
| author_sort | B. I. Kantemirova |
| collection | DOAJ |
| description | For the first time at children of five various nationalities living in the territory of the Astrakhan region, polymorphism of a gene of CYP2C19 on a polymorphic marker of G681A is studied. Statistically authentic distinction in frequencies of occurrence of genotypes of CYP2C19 associated both with fast, and with a slow metabolism of medicinal means substrata that testifies to importance of individual studying of polymorphism of CYP2C19 is revealed. It is studied, on restored glutathione blood, activity of the second phase of biotransformation of anti-epileptic preparations. Offers on improvement of pharmacotherapy of epilepsy at children are created. |
| first_indexed | 2024-04-10T02:47:45Z |
| format | Article |
| id | doaj.art-6499ece76fda423787eefc6eab5b2dfe |
| institution | Directory Open Access Journal |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| last_indexed | 2024-04-10T02:47:45Z |
| publishDate | 2016-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj.art-6499ece76fda423787eefc6eab5b2dfe2023-03-13T07:44:15ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882016-09-01431418267WAYS OF IMPROVEMENT OF PHARMACOTHERAPY OF EPILEPSY AT CHILDREN: FOCUS ON SPECIFIC FEATURES OF BIOTRANSFORMATION MEDICINESB. I. Kantemirova0A. K. Starodubtsev1D. A. Sychev2V. V. Belopasov3Zh. M. Tsotsonava4V. I. Griganov5GBOU VPO «Astrakhan state medical academy» Ministry of Public Health and Social Development of RussiaGBOU VPO the first MGMU of I.M. Setchenov Ministry of Public Health and Social Development of Russia, MoscowGBOU VPO the first MGMU of I.M. Setchenov Ministry of Public Health and Social Development of Russia, MoscowGBOU VPO «Astrakhan state medical academy» Ministry of Public Health and Social Development of RussiaGBOU VPO «Astrakhan state medical academy» Ministry of Public Health and Social Development of RussiaGBOU VPO «Astrakhan state medical academy» Ministry of Public Health and Social Development of RussiaFor the first time at children of five various nationalities living in the territory of the Astrakhan region, polymorphism of a gene of CYP2C19 on a polymorphic marker of G681A is studied. Statistically authentic distinction in frequencies of occurrence of genotypes of CYP2C19 associated both with fast, and with a slow metabolism of medicinal means substrata that testifies to importance of individual studying of polymorphism of CYP2C19 is revealed. It is studied, on restored glutathione blood, activity of the second phase of biotransformation of anti-epileptic preparations. Offers on improvement of pharmacotherapy of epilepsy at children are created.https://www.epilepsia.su/jour/article/view/268biotransformationchildrencytochrome p 450 isoenzymesepilepsypharmacotherapy improvementethnic pharmacogenetics |
| spellingShingle | B. I. Kantemirova A. K. Starodubtsev D. A. Sychev V. V. Belopasov Zh. M. Tsotsonava V. I. Griganov WAYS OF IMPROVEMENT OF PHARMACOTHERAPY OF EPILEPSY AT CHILDREN: FOCUS ON SPECIFIC FEATURES OF BIOTRANSFORMATION MEDICINES Эпилепсия и пароксизмальные состояния biotransformation children cytochrome p 450 isoenzymes epilepsy pharmacotherapy improvement ethnic pharmacogenetics |
| title | WAYS OF IMPROVEMENT OF PHARMACOTHERAPY OF EPILEPSY AT CHILDREN: FOCUS ON SPECIFIC FEATURES OF BIOTRANSFORMATION MEDICINES |
| title_full | WAYS OF IMPROVEMENT OF PHARMACOTHERAPY OF EPILEPSY AT CHILDREN: FOCUS ON SPECIFIC FEATURES OF BIOTRANSFORMATION MEDICINES |
| title_fullStr | WAYS OF IMPROVEMENT OF PHARMACOTHERAPY OF EPILEPSY AT CHILDREN: FOCUS ON SPECIFIC FEATURES OF BIOTRANSFORMATION MEDICINES |
| title_full_unstemmed | WAYS OF IMPROVEMENT OF PHARMACOTHERAPY OF EPILEPSY AT CHILDREN: FOCUS ON SPECIFIC FEATURES OF BIOTRANSFORMATION MEDICINES |
| title_short | WAYS OF IMPROVEMENT OF PHARMACOTHERAPY OF EPILEPSY AT CHILDREN: FOCUS ON SPECIFIC FEATURES OF BIOTRANSFORMATION MEDICINES |
| title_sort | ways of improvement of pharmacotherapy of epilepsy at children focus on specific features of biotransformation medicines |
| topic | biotransformation children cytochrome p 450 isoenzymes epilepsy pharmacotherapy improvement ethnic pharmacogenetics |
| url | https://www.epilepsia.su/jour/article/view/268 |
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