Trypanosoma (herpetosoma) Rangeli tejera, 1920: influence of host weight, size of inoculum, and route of infection upon experimental parasitemia
To study the influence of host age, inoculum size, and route of infection on Trypanosoma (Herpetosoma) rangeli, 12 lots of 6.0 g albino mice (NMRI strain) were infected up. with from 25x10¹ to 25x10(6) trypomastigotes/gram body weight harvested from LIT medium. The lower inocula produced low but per...
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| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
1988-09-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821988000300007 |
| _version_ | 1811335950909833216 |
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| author | Felix Tejero Natiela Galli Servio Urdaneta-Morales |
| author_facet | Felix Tejero Natiela Galli Servio Urdaneta-Morales |
| author_sort | Felix Tejero |
| collection | DOAJ |
| description | To study the influence of host age, inoculum size, and route of infection on Trypanosoma (Herpetosoma) rangeli, 12 lots of 6.0 g albino mice (NMRI strain) were infected up. with from 25x10¹ to 25x10(6) trypomastigotes/gram body weight harvested from LIT medium. The lower inocula produced low but persistent parasitemias, while the higher inocula produced high levels of parasitemia that fell quickly, suggesting the mobilization of resistance mechanisms. In other experiments, i.p. inoculation produced higher parasitemias than s.c. inoculation, and 6.0 g mice had higher parasitemias than 16.0 or 26.0 g mice. Thus, a standard methodology would seem to be necessary in the study of the various strains and/or species that may make up the T. rangeli complex.<br>Para estudiar la influencia de la edad del hosvedador. del tamano del inoculo y su ruta de administración sobre la infection por Trypanosoma (Herpetosoma) rangeli, fueron inoculados i.p. 12 lotes de ratones albinos (cepa NMRI) de 6.0gdepeso con 25.0 - 2.5x10(6) metatripomastigotes/g obtenidos del medio LIT. Los inóculos mas bajos produjeron parasitemias bajas pero persistentes; los inóculos mas elevados originaron niveles altos de parasitemias que cayeron prontamente, sugiriendo la mobilization de mecanismos de resistencia a niveles diferentes de actividad. En otros experimentos, la inoculation i.p. y el uso de ratones de 6.0 g dieron parasitemias mas elevadas que cuando se usaron inoculaciones s.c. o animates de 16.0 y 26.0g. Estos resultados indican la necesidad de emplear una metodologia uniforme cuando se investigue elposible carácter heterogénico del complejo de T. rangeli. |
| first_indexed | 2024-04-13T17:31:26Z |
| format | Article |
| id | doaj.art-649adc887e524938a9ae791e7d8ea3a5 |
| institution | Directory Open Access Journal |
| issn | 0037-8682 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T17:31:26Z |
| publishDate | 1988-09-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-649adc887e524938a9ae791e7d8ea3a52022-12-22T02:37:32ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical0037-86821678-98491988-09-01213135138Trypanosoma (herpetosoma) Rangeli tejera, 1920: influence of host weight, size of inoculum, and route of infection upon experimental parasitemiaFelix TejeroNatiela GalliServio Urdaneta-MoralesTo study the influence of host age, inoculum size, and route of infection on Trypanosoma (Herpetosoma) rangeli, 12 lots of 6.0 g albino mice (NMRI strain) were infected up. with from 25x10¹ to 25x10(6) trypomastigotes/gram body weight harvested from LIT medium. The lower inocula produced low but persistent parasitemias, while the higher inocula produced high levels of parasitemia that fell quickly, suggesting the mobilization of resistance mechanisms. In other experiments, i.p. inoculation produced higher parasitemias than s.c. inoculation, and 6.0 g mice had higher parasitemias than 16.0 or 26.0 g mice. Thus, a standard methodology would seem to be necessary in the study of the various strains and/or species that may make up the T. rangeli complex.<br>Para estudiar la influencia de la edad del hosvedador. del tamano del inoculo y su ruta de administración sobre la infection por Trypanosoma (Herpetosoma) rangeli, fueron inoculados i.p. 12 lotes de ratones albinos (cepa NMRI) de 6.0gdepeso con 25.0 - 2.5x10(6) metatripomastigotes/g obtenidos del medio LIT. Los inóculos mas bajos produjeron parasitemias bajas pero persistentes; los inóculos mas elevados originaron niveles altos de parasitemias que cayeron prontamente, sugiriendo la mobilization de mecanismos de resistencia a niveles diferentes de actividad. En otros experimentos, la inoculation i.p. y el uso de ratones de 6.0 g dieron parasitemias mas elevadas que cuando se usaron inoculaciones s.c. o animates de 16.0 y 26.0g. Estos resultados indican la necesidad de emplear una metodologia uniforme cuando se investigue elposible carácter heterogénico del complejo de T. rangeli.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821988000300007Trypanosoma (Herpetosoma) rangeliInoculum sizeInfection routeHost weightImmune resistance |
| spellingShingle | Felix Tejero Natiela Galli Servio Urdaneta-Morales Trypanosoma (herpetosoma) Rangeli tejera, 1920: influence of host weight, size of inoculum, and route of infection upon experimental parasitemia Revista da Sociedade Brasileira de Medicina Tropical Trypanosoma (Herpetosoma) rangeli Inoculum size Infection route Host weight Immune resistance |
| title | Trypanosoma (herpetosoma) Rangeli tejera, 1920: influence of host weight, size of inoculum, and route of infection upon experimental parasitemia |
| title_full | Trypanosoma (herpetosoma) Rangeli tejera, 1920: influence of host weight, size of inoculum, and route of infection upon experimental parasitemia |
| title_fullStr | Trypanosoma (herpetosoma) Rangeli tejera, 1920: influence of host weight, size of inoculum, and route of infection upon experimental parasitemia |
| title_full_unstemmed | Trypanosoma (herpetosoma) Rangeli tejera, 1920: influence of host weight, size of inoculum, and route of infection upon experimental parasitemia |
| title_short | Trypanosoma (herpetosoma) Rangeli tejera, 1920: influence of host weight, size of inoculum, and route of infection upon experimental parasitemia |
| title_sort | trypanosoma herpetosoma rangeli tejera 1920 influence of host weight size of inoculum and route of infection upon experimental parasitemia |
| topic | Trypanosoma (Herpetosoma) rangeli Inoculum size Infection route Host weight Immune resistance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821988000300007 |
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