Compartmentalized Signaling in Aging and Neurodegeneration
The cyclic AMP (cAMP) signalling cascade is necessary for cell homeostasis and plays important roles in many processes. This is particularly relevant during ageing and age-related diseases, where drastic changes, generally decreases, in cAMP levels have been associated with the progressive decline i...
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MDPI AG
2021-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/2/464 |
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| author | Giulietta Di Benedetto Liliana F. Iannucci Nicoletta C. Surdo Sofia Zanin Filippo Conca Francesca Grisan Andrea Gerbino Konstantinos Lefkimmiatis |
| author_facet | Giulietta Di Benedetto Liliana F. Iannucci Nicoletta C. Surdo Sofia Zanin Filippo Conca Francesca Grisan Andrea Gerbino Konstantinos Lefkimmiatis |
| author_sort | Giulietta Di Benedetto |
| collection | DOAJ |
| description | The cyclic AMP (cAMP) signalling cascade is necessary for cell homeostasis and plays important roles in many processes. This is particularly relevant during ageing and age-related diseases, where drastic changes, generally decreases, in cAMP levels have been associated with the progressive decline in overall cell function and, eventually, the loss of cellular integrity. The functional relevance of reduced cAMP is clearly supported by the finding that increases in cAMP levels can reverse some of the effects of ageing. Nevertheless, despite these observations, the molecular mechanisms underlying the dysregulation of cAMP signalling in ageing are not well understood. Compartmentalization is widely accepted as the modality through which cAMP achieves its functional specificity; therefore, it is important to understand whether and how this mechanism is affected during ageing and to define which is its contribution to this process. Several animal models demonstrate the importance of specific cAMP signalling components in ageing, however, how age-related changes in each of these elements affect the compartmentalization of the cAMP pathway is largely unknown. In this review, we explore the connection of single components of the cAMP signalling cascade to ageing and age-related diseases whilst elaborating the literature in the context of cAMP signalling compartmentalization. |
| first_indexed | 2024-03-09T00:39:29Z |
| format | Article |
| id | doaj.art-649c6f8625504f8cbf83a9f9200d4ef7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T00:39:29Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-649c6f8625504f8cbf83a9f9200d4ef72023-12-11T17:56:40ZengMDPI AGCells2073-44092021-02-0110246410.3390/cells10020464Compartmentalized Signaling in Aging and NeurodegenerationGiulietta Di Benedetto0Liliana F. Iannucci1Nicoletta C. Surdo2Sofia Zanin3Filippo Conca4Francesca Grisan5Andrea Gerbino6Konstantinos Lefkimmiatis7Neuroscience Institute, National Research Council of Italy (CNR), 35121 Padova, ItalyVeneto Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, 35129 Padova, ItalyNeuroscience Institute, National Research Council of Italy (CNR), 35121 Padova, ItalyVeneto Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, 35129 Padova, ItalyVeneto Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, 35129 Padova, ItalyVeneto Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, 35129 Padova, ItalyDepartment of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, 70121 Bari, ItalyVeneto Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, 35129 Padova, ItalyThe cyclic AMP (cAMP) signalling cascade is necessary for cell homeostasis and plays important roles in many processes. This is particularly relevant during ageing and age-related diseases, where drastic changes, generally decreases, in cAMP levels have been associated with the progressive decline in overall cell function and, eventually, the loss of cellular integrity. The functional relevance of reduced cAMP is clearly supported by the finding that increases in cAMP levels can reverse some of the effects of ageing. Nevertheless, despite these observations, the molecular mechanisms underlying the dysregulation of cAMP signalling in ageing are not well understood. Compartmentalization is widely accepted as the modality through which cAMP achieves its functional specificity; therefore, it is important to understand whether and how this mechanism is affected during ageing and to define which is its contribution to this process. Several animal models demonstrate the importance of specific cAMP signalling components in ageing, however, how age-related changes in each of these elements affect the compartmentalization of the cAMP pathway is largely unknown. In this review, we explore the connection of single components of the cAMP signalling cascade to ageing and age-related diseases whilst elaborating the literature in the context of cAMP signalling compartmentalization.https://www.mdpi.com/2073-4409/10/2/464agingneurodegenerationcompartmentalizationcAMPPKA |
| spellingShingle | Giulietta Di Benedetto Liliana F. Iannucci Nicoletta C. Surdo Sofia Zanin Filippo Conca Francesca Grisan Andrea Gerbino Konstantinos Lefkimmiatis Compartmentalized Signaling in Aging and Neurodegeneration Cells aging neurodegeneration compartmentalization cAMP PKA |
| title | Compartmentalized Signaling in Aging and Neurodegeneration |
| title_full | Compartmentalized Signaling in Aging and Neurodegeneration |
| title_fullStr | Compartmentalized Signaling in Aging and Neurodegeneration |
| title_full_unstemmed | Compartmentalized Signaling in Aging and Neurodegeneration |
| title_short | Compartmentalized Signaling in Aging and Neurodegeneration |
| title_sort | compartmentalized signaling in aging and neurodegeneration |
| topic | aging neurodegeneration compartmentalization cAMP PKA |
| url | https://www.mdpi.com/2073-4409/10/2/464 |
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