Promoter methylation and large intragenic rearrangements of <it>DPYD </it>are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients

Promoter methylation and large intragenic rearrangements of <it>DPYD </it>are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients

<p>Abstract</p> <p>Background</p> <p>Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (<it>DPYD</it>).</p> <...

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Bibliographic Details
Main Authors: Savva-Bordalo Joana, Ramalho-Carvalho João, Pinheiro Manuela, Costa Vera L, Rodrigues Ângelo, Dias Paula C, Veiga Isabel, Machado Manuela, Teixeira Manuel R, Henrique Rui, Jerónimo Carmen
Format: Article
Language:English
Published: BMC 2010-09-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/10/470

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