The Talented LncRNAs: Meshing into Transcriptional Regulatory Networks in Cancer
As a group of diseases characterized by uncontrollable cell growth, cancer is highly multifaceted in how it overrides checkpoints controlling proliferation. Amongst the regulators of these checkpoints, long non-coding RNAs (lncRNAs) can have key roles in why natural biological processes go haywire....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/13/3433 |
| _version_ | 1797591969646510080 |
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| author | Dana Segal Josée Dostie |
| author_facet | Dana Segal Josée Dostie |
| author_sort | Dana Segal |
| collection | DOAJ |
| description | As a group of diseases characterized by uncontrollable cell growth, cancer is highly multifaceted in how it overrides checkpoints controlling proliferation. Amongst the regulators of these checkpoints, long non-coding RNAs (lncRNAs) can have key roles in why natural biological processes go haywire. LncRNAs represent a large class of regulatory transcripts that can localize anywhere in cells. They were found to affect gene expression on many levels from transcription to mRNA translation and even protein stability. LncRNA participation in such control mechanisms can depend on cell context, with given transcripts sometimes acting as oncogenes or tumor suppressors. Importantly, the tissue-specificity and low expression levels of lncRNAs make them attractive therapeutic targets or biomarkers. Here, we review the various cellular processes affected by lncRNAs and outline molecular strategies they use to control gene expression, particularly in cancer and in relation to transcription factors. |
| first_indexed | 2024-03-11T01:45:09Z |
| format | Article |
| id | doaj.art-649d8031a0694372bc1e0becb6f72a46 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:45:09Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-649d8031a0694372bc1e0becb6f72a462023-11-18T16:16:56ZengMDPI AGCancers2072-66942023-06-011513343310.3390/cancers15133433The Talented LncRNAs: Meshing into Transcriptional Regulatory Networks in CancerDana Segal0Josée Dostie1Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, CanadaDepartment of Biochemistry, McGill University, Montréal, QC H3G 1Y6, CanadaAs a group of diseases characterized by uncontrollable cell growth, cancer is highly multifaceted in how it overrides checkpoints controlling proliferation. Amongst the regulators of these checkpoints, long non-coding RNAs (lncRNAs) can have key roles in why natural biological processes go haywire. LncRNAs represent a large class of regulatory transcripts that can localize anywhere in cells. They were found to affect gene expression on many levels from transcription to mRNA translation and even protein stability. LncRNA participation in such control mechanisms can depend on cell context, with given transcripts sometimes acting as oncogenes or tumor suppressors. Importantly, the tissue-specificity and low expression levels of lncRNAs make them attractive therapeutic targets or biomarkers. Here, we review the various cellular processes affected by lncRNAs and outline molecular strategies they use to control gene expression, particularly in cancer and in relation to transcription factors.https://www.mdpi.com/2072-6694/15/13/3433cancerlong non-coding RNAtranscription factorepigenetictranscriptionchromatin |
| spellingShingle | Dana Segal Josée Dostie The Talented LncRNAs: Meshing into Transcriptional Regulatory Networks in Cancer Cancers cancer long non-coding RNA transcription factor epigenetic transcription chromatin |
| title | The Talented LncRNAs: Meshing into Transcriptional Regulatory Networks in Cancer |
| title_full | The Talented LncRNAs: Meshing into Transcriptional Regulatory Networks in Cancer |
| title_fullStr | The Talented LncRNAs: Meshing into Transcriptional Regulatory Networks in Cancer |
| title_full_unstemmed | The Talented LncRNAs: Meshing into Transcriptional Regulatory Networks in Cancer |
| title_short | The Talented LncRNAs: Meshing into Transcriptional Regulatory Networks in Cancer |
| title_sort | talented lncrnas meshing into transcriptional regulatory networks in cancer |
| topic | cancer long non-coding RNA transcription factor epigenetic transcription chromatin |
| url | https://www.mdpi.com/2072-6694/15/13/3433 |
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