Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using peptide block entropy

Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using peptide block entropy

Broad coverage of the pathogen population is particularly important when designing CD8+ T-cell epitope vaccines against viral pathogens. Traditional approaches to assembling broadly covering sets of peptides are commonly based on assembling highly conserved epitopes. Peptide block entropy analysis i...

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Bibliographic Details
Main Authors:	Lars Ronn Olsen, Guang Lan eZhang, Derin B Keskin, Ellis L Reinherz, Vladimir eBrusic
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2011-12-01
Series:	Frontiers in Immunology
Subjects:	immunoinformatics antigenic diversity epitope-based vaccines polyvalent vaccines reverse vaccinology vaccine informatics
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00069/full

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