Effect of High-intensity Intermittent Swimming Training on peroxisome proliferator-activated receptors-αand Liver Enzymes in Non-alcoholic Steatohepatitis Male Rats
Introduction: Accumulation of fat in the liver tissue is known as the most important cause of non-alcoholic steatohepatitis, which is associated with a decrease in the protein of hepatic peroxisome proliferator-activated receptors (PPAR-α). This study aimed to investigate the effect of eight weeks o...
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| Format: | Article |
| Language: | fas |
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Shahid Sadoughi University of Medical Sciences
2023-01-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| Subjects: | |
| Online Access: | http://jssu.ssu.ac.ir/article-1-5812-en.html |
| _version_ | 1811177066647781376 |
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| author | Alireza Jowhari Farhad Daryanoosh Maryam Koushkie Jahromi Ali Akbar Nekooeian |
| author_facet | Alireza Jowhari Farhad Daryanoosh Maryam Koushkie Jahromi Ali Akbar Nekooeian |
| author_sort | Alireza Jowhari |
| collection | DOAJ |
| description | Introduction: Accumulation of fat in the liver tissue is known as the most important cause of non-alcoholic steatohepatitis, which is associated with a decrease in the protein of hepatic peroxisome proliferator-activated receptors (PPAR-α). This study aimed to investigate the effect of eight weeks of high-intensity interval training (HIST) on PPAR-α and liver enzymes in high-fat diet-induced non-alcoholic steatohepatitis rats.
Methods: The current research was semi-experimental. 40 Spraguedauli male rats (age: 6 to 8 weeks and weight: 230 ± 20 grams) were selected and divided into two equal groups, healthy and high-fat diet (HFD). The HFD group was subjected to gavage for eight weeks with the aim of inducing the disease. Rats were divided into four groups: control-healthy (n=9), healthy-swimming (n=9), control- disease (n=9) and disease -swimming (n=9). The training groups performed HIST for eight weeks (three sessions per week, each session lasting 30 minutes). In the end, liver PPAR-α was measured by western blot analysis; and ALT, AST and GGT enzymes in serum level were measured by photometric method. One-way analysis of variance and Bonferroni's post hoc test were used to analyze the data. Significant level (P≥0.05) and all statistical methods were performed using SPSS16 software.
Results: HIST controlled the weight gain caused by HFD and there was a significant decrease in serum ALT and AST in the healthy-swimming and sick-swimming groups compared to the control-patient group and a significant decrease in serum GGT in the healthy-swimming group compared to the control-patient (P≤0.001) and patient-swimming (P≤0.044) were observed. A significant increase in hepatic PPAR-α was observed in healthy-swimming patients compared to the control-patients (P≤0.002).
Conclusion: HIST can control body weight and reduce liver enzymes. However, more research is needed to obtain definitive results. |
| first_indexed | 2024-04-10T22:56:53Z |
| format | Article |
| id | doaj.art-649fe093afcc4e6784ca17259ef0d24f |
| institution | Directory Open Access Journal |
| issn | 2228-5741 2228-5733 |
| language | fas |
| last_indexed | 2024-04-10T22:56:53Z |
| publishDate | 2023-01-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| spelling | doaj.art-649fe093afcc4e6784ca17259ef0d24f2023-01-14T09:56:29ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332023-01-01301060346051Effect of High-intensity Intermittent Swimming Training on peroxisome proliferator-activated receptors-αand Liver Enzymes in Non-alcoholic Steatohepatitis Male RatsAlireza Jowhari0Farhad Daryanoosh1Maryam Koushkie Jahromi2Ali Akbar Nekooeian3 Faculty of Educational Sciences and Psychology, Department of Sports Sciences, Shiraz University, Shiraz, Iran. Faculty of Educational Sciences and Psychology, Department of Sports Sciences, Shiraz University, Shiraz, Iran. Faculty of Educational Sciences and Psychology, Department of Sports Sciences, Shiraz University, Shiraz, Iran. Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Introduction: Accumulation of fat in the liver tissue is known as the most important cause of non-alcoholic steatohepatitis, which is associated with a decrease in the protein of hepatic peroxisome proliferator-activated receptors (PPAR-α). This study aimed to investigate the effect of eight weeks of high-intensity interval training (HIST) on PPAR-α and liver enzymes in high-fat diet-induced non-alcoholic steatohepatitis rats. Methods: The current research was semi-experimental. 40 Spraguedauli male rats (age: 6 to 8 weeks and weight: 230 ± 20 grams) were selected and divided into two equal groups, healthy and high-fat diet (HFD). The HFD group was subjected to gavage for eight weeks with the aim of inducing the disease. Rats were divided into four groups: control-healthy (n=9), healthy-swimming (n=9), control- disease (n=9) and disease -swimming (n=9). The training groups performed HIST for eight weeks (three sessions per week, each session lasting 30 minutes). In the end, liver PPAR-α was measured by western blot analysis; and ALT, AST and GGT enzymes in serum level were measured by photometric method. One-way analysis of variance and Bonferroni's post hoc test were used to analyze the data. Significant level (P≥0.05) and all statistical methods were performed using SPSS16 software. Results: HIST controlled the weight gain caused by HFD and there was a significant decrease in serum ALT and AST in the healthy-swimming and sick-swimming groups compared to the control-patient group and a significant decrease in serum GGT in the healthy-swimming group compared to the control-patient (P≤0.001) and patient-swimming (P≤0.044) were observed. A significant increase in hepatic PPAR-α was observed in healthy-swimming patients compared to the control-patients (P≤0.002). Conclusion: HIST can control body weight and reduce liver enzymes. However, more research is needed to obtain definitive results.http://jssu.ssu.ac.ir/article-1-5812-en.htmlnon-alcoholic steatohepatitishigh-intensity interval swimminghepatic peroxisome proliferator activator proteinliver enzymes. |
| spellingShingle | Alireza Jowhari Farhad Daryanoosh Maryam Koushkie Jahromi Ali Akbar Nekooeian Effect of High-intensity Intermittent Swimming Training on peroxisome proliferator-activated receptors-αand Liver Enzymes in Non-alcoholic Steatohepatitis Male Rats Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd non-alcoholic steatohepatitis high-intensity interval swimming hepatic peroxisome proliferator activator protein liver enzymes. |
| title | Effect of High-intensity Intermittent Swimming Training on peroxisome proliferator-activated receptors-αand Liver Enzymes in Non-alcoholic Steatohepatitis Male Rats |
| title_full | Effect of High-intensity Intermittent Swimming Training on peroxisome proliferator-activated receptors-αand Liver Enzymes in Non-alcoholic Steatohepatitis Male Rats |
| title_fullStr | Effect of High-intensity Intermittent Swimming Training on peroxisome proliferator-activated receptors-αand Liver Enzymes in Non-alcoholic Steatohepatitis Male Rats |
| title_full_unstemmed | Effect of High-intensity Intermittent Swimming Training on peroxisome proliferator-activated receptors-αand Liver Enzymes in Non-alcoholic Steatohepatitis Male Rats |
| title_short | Effect of High-intensity Intermittent Swimming Training on peroxisome proliferator-activated receptors-αand Liver Enzymes in Non-alcoholic Steatohepatitis Male Rats |
| title_sort | effect of high intensity intermittent swimming training on peroxisome proliferator activated receptors αand liver enzymes in non alcoholic steatohepatitis male rats |
| topic | non-alcoholic steatohepatitis high-intensity interval swimming hepatic peroxisome proliferator activator protein liver enzymes. |
| url | http://jssu.ssu.ac.ir/article-1-5812-en.html |
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