Development of non-alcoholic steatohepatitis is associated with gut microbiota but not with oxysterol enzymes CH25H, EBI2, or CYP7B1 in mice

Development of non-alcoholic steatohepatitis is associated with gut microbiota but not with oxysterol enzymes CH25H, EBI2, or CYP7B1 in mice

Abstract Liver steatosis is the most frequent liver disorder and its advanced stage, non-alcoholic steatohepatitis (NASH), will soon become the main reason for liver fibrosis and cirrhosis. The “multiple hits hypothesis” suggests that progression from simple steatosis to NASH is triggered by multipl...

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Bibliographic Details
Main Authors: Jacqueline Wyss, Tina Raselli, Annika Wyss, Anja Telzerow, Gerhard Rogler, Niklas Krupka, Bahtiyar Yilmaz, Thomas S. B. Schmidt, Benjamin Misselwitz
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Microbiology
Subjects:
NASH
Steatosis
Oxysterol
Microbiota
EBI2
Online Access:https://doi.org/10.1186/s12866-024-03195-7

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