A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycle

A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycle

Abstract Background Irinotecan (CPT-11) is a classic chemotherapeutic agent that plays an important role in the clinical treatment of metastatic colon cancer and other malignant tumors. We previously designed a series of novel irinotecan derivatives. In this study, we select one representative, ZBH-...

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Bibliographic Details
Main Authors: Yongqi Li, Dawei Zhao, Wenqiu Zhang, Miaomiao Yang, Zhihui Wu, Weiguo Shi, Shijie Lan, Zhen Guo, Hong Yu, Di Wu
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Translational Medicine
Subjects:
Irinotecan derivative ZBH-01
Colorectal cancer
Next-generation sequencing
Differentially expressed genes
Cell cycle
Apoptosis
Online Access:https://doi.org/10.1186/s12967-023-04196-2

Internet

https://doi.org/10.1186/s12967-023-04196-2

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