Chemical modification strategies to prepare advanced protein-based biomaterials
Nature is a superb source of inspiration when it comes to the development of biomaterials. Proteins, an exquisite asset virtually involved in all biological functions, are envisioned as a biomaterial due to their ability to be chemically modified. Owing to the rich chemical repertoire provided by th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-03-01
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| Series: | Biomaterials and Biosystems |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666534421000039 |
| _version_ | 1818865516446482432 |
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| author | Maria C. Gomes João F. Mano |
| author_facet | Maria C. Gomes João F. Mano |
| author_sort | Maria C. Gomes |
| collection | DOAJ |
| description | Nature is a superb source of inspiration when it comes to the development of biomaterials. Proteins, an exquisite asset virtually involved in all biological functions, are envisioned as a biomaterial due to their ability to be chemically modified. Owing to the rich chemical repertoire provided by the side chains and C-/N-terminus present in their backbone, scientists are pursuing chemical ways to upgrade isolated proteins, while maintaining their biological activity or relevant structural properties. By inserting chemical motifs, the crosslinking capability of proteins and capability to attach biochemical and molecular groups can be controlled yielding nano to macro constructs and hydrogels with improved physicochemical and mechanical properties. These cutting-edge approaches elevate the potential use of proteins as promising biomaterials for biotechnology and biomedicine. |
| first_indexed | 2024-12-19T10:48:48Z |
| format | Article |
| id | doaj.art-64a6d7aaa0904089a26ba2d2328d5361 |
| institution | Directory Open Access Journal |
| issn | 2666-5344 |
| language | English |
| last_indexed | 2024-12-19T10:48:48Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomaterials and Biosystems |
| spelling | doaj.art-64a6d7aaa0904089a26ba2d2328d53612022-12-21T20:25:08ZengElsevierBiomaterials and Biosystems2666-53442021-03-011100010Chemical modification strategies to prepare advanced protein-based biomaterialsMaria C. Gomes0João F. Mano1Corresponding authors.; Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalCorresponding authors.; Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalNature is a superb source of inspiration when it comes to the development of biomaterials. Proteins, an exquisite asset virtually involved in all biological functions, are envisioned as a biomaterial due to their ability to be chemically modified. Owing to the rich chemical repertoire provided by the side chains and C-/N-terminus present in their backbone, scientists are pursuing chemical ways to upgrade isolated proteins, while maintaining their biological activity or relevant structural properties. By inserting chemical motifs, the crosslinking capability of proteins and capability to attach biochemical and molecular groups can be controlled yielding nano to macro constructs and hydrogels with improved physicochemical and mechanical properties. These cutting-edge approaches elevate the potential use of proteins as promising biomaterials for biotechnology and biomedicine.http://www.sciencedirect.com/science/article/pii/S2666534421000039 |
| spellingShingle | Maria C. Gomes João F. Mano Chemical modification strategies to prepare advanced protein-based biomaterials Biomaterials and Biosystems |
| title | Chemical modification strategies to prepare advanced protein-based biomaterials |
| title_full | Chemical modification strategies to prepare advanced protein-based biomaterials |
| title_fullStr | Chemical modification strategies to prepare advanced protein-based biomaterials |
| title_full_unstemmed | Chemical modification strategies to prepare advanced protein-based biomaterials |
| title_short | Chemical modification strategies to prepare advanced protein-based biomaterials |
| title_sort | chemical modification strategies to prepare advanced protein based biomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2666534421000039 |
| work_keys_str_mv | AT mariacgomes chemicalmodificationstrategiestoprepareadvancedproteinbasedbiomaterials AT joaofmano chemicalmodificationstrategiestoprepareadvancedproteinbasedbiomaterials |