Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories
"nAbstract "nIntroduction: The current study evaluated the value of red blood cell (RBC) indices and the corresponding cut- off points for β-thalassemia control programs in Iran. "nMaterials and Methods: 1,150 individuals (575 couples) with low RBC indices and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2010-01-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/17158.pdf&manuscript_id=17158 |
| _version_ | 1797722969742508032 |
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| author | Alireza Moafi Sadeg Valian Zahra Nikyar Mehrdad Zeinalian Maryam Momenzadeh Soheila Rahgozar |
| author_facet | Alireza Moafi Sadeg Valian Zahra Nikyar Mehrdad Zeinalian Maryam Momenzadeh Soheila Rahgozar |
| author_sort | Alireza Moafi |
| collection | DOAJ |
| description | "nAbstract "nIntroduction: The current study evaluated the value of red blood cell (RBC) indices and the corresponding cut- off points for β-thalassemia control programs in Iran. "nMaterials and Methods: 1,150 individuals (575 couples) with low RBC indices and normal hemoglobin A2 who had been referred to the Genetic Centre of Isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2006-2008. β-thalassemia mutations were evaluated. "nResults: β-thalassemia was identified in 67.8% of the cases with both mean corpuscular volume (MCV) less than 78fl and mean corpuscular hemoglobin (MCH) less than 26 pg. However, 4.1% of the individuals with "n78≤ MCV≤ 80 tested positive for thalassemia. MCV showed a higher diagnostic reliability than MCH. However, the accompaniment of MCH<26 with MCV<78 increased the risk of thalassemia 35 times. A significant association was found between the prevalence of minor β-thalassemia and educational levels, race and familial relationships. "nConclusion: According to the results of this study, it seems that MCV=80fl can be used as a proper cut- off point for the screening of minor β-thalassemia. Although in the present study MCV was found to have a higher diagnostic reliability than MCH, MCH <26 along with MCV are very helpful indices for the counselor physician to estimate the risk of minor β-thalassemia more accurately. "n  "nKey words: Minor β-Thalassemia, Screening, MCH, MCV, Thalassemia Preventing Program, |
| first_indexed | 2024-03-12T09:55:27Z |
| format | Article |
| id | doaj.art-64a6e4d6108d4e38bebf4624c22f1fb1 |
| institution | Directory Open Access Journal |
| issn | 2008-3009 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T09:55:27Z |
| publishDate | 2010-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-64a6e4d6108d4e38bebf4624c22f1fb12023-09-02T12:13:16ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-30092008-22072010-01-01412327Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic LaboratoriesAlireza MoafiSadeg ValianZahra NikyarMehrdad ZeinalianMaryam MomenzadehSoheila Rahgozar"nAbstract "nIntroduction: The current study evaluated the value of red blood cell (RBC) indices and the corresponding cut- off points for β-thalassemia control programs in Iran. "nMaterials and Methods: 1,150 individuals (575 couples) with low RBC indices and normal hemoglobin A2 who had been referred to the Genetic Centre of Isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2006-2008. β-thalassemia mutations were evaluated. "nResults: β-thalassemia was identified in 67.8% of the cases with both mean corpuscular volume (MCV) less than 78fl and mean corpuscular hemoglobin (MCH) less than 26 pg. However, 4.1% of the individuals with "n78≤ MCV≤ 80 tested positive for thalassemia. MCV showed a higher diagnostic reliability than MCH. However, the accompaniment of MCH<26 with MCV<78 increased the risk of thalassemia 35 times. A significant association was found between the prevalence of minor β-thalassemia and educational levels, race and familial relationships. "nConclusion: According to the results of this study, it seems that MCV=80fl can be used as a proper cut- off point for the screening of minor β-thalassemia. Although in the present study MCV was found to have a higher diagnostic reliability than MCH, MCH <26 along with MCV are very helpful indices for the counselor physician to estimate the risk of minor β-thalassemia more accurately. "n  "nKey words: Minor β-Thalassemia, Screening, MCH, MCV, Thalassemia Preventing Program,http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/17158.pdf&manuscript_id=17158 Minor β-ThalassemiaScreeningMCHMCVThalassemia Preventing Program |
| spellingShingle | Alireza Moafi Sadeg Valian Zahra Nikyar Mehrdad Zeinalian Maryam Momenzadeh Soheila Rahgozar Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories International Journal of Hematology-Oncology and Stem Cell Research Minor β-Thalassemia Screening MCH MCV Thalassemia Preventing Program |
| title | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_full | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_fullStr | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_full_unstemmed | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_short | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_sort | prevalence of minor β thalassemia based on rbc indices among final suspected individuals in premarital screening program referred to genetic laboratories |
| topic | Minor β-Thalassemia Screening MCH MCV Thalassemia Preventing Program |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/17158.pdf&manuscript_id=17158 |
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