Association between triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in Japanese
Abstract Abnormal lipid metabolism is known to increases the risk for metabolic diseases, such as type 2 diabetes mellitus(T2DM). The relationship between baseline ratio of triglyceride to HDL cholesterol (TG/HDL-C) and T2DM in Japanese adults was investigated in this study. Our secondary analysis i...
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| Format: | Article |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25585-5 |
| _version_ | 1797864833964572672 |
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| author | Huijuan Wang Changming Wang Xiuping Xuan Zhouni Xie Yuanyuan Qiu Huiping Qin Zhong Xiaoning |
| author_facet | Huijuan Wang Changming Wang Xiuping Xuan Zhouni Xie Yuanyuan Qiu Huiping Qin Zhong Xiaoning |
| author_sort | Huijuan Wang |
| collection | DOAJ |
| description | Abstract Abnormal lipid metabolism is known to increases the risk for metabolic diseases, such as type 2 diabetes mellitus(T2DM). The relationship between baseline ratio of triglyceride to HDL cholesterol (TG/HDL-C) and T2DM in Japanese adults was investigated in this study. Our secondary analysis included 8419 male and 7034 female Japanese subjects who were free of diabetes at baseline. The correlation between baseline TG/HDL-C and T2DM was analyzed by a proportional risk regression model, the nonlinear correlation between baseline TG/HDL-C and T2DM was analyzed by a generalized additive model (GAM), and the threshold effect analysis was performed by a segmented regression model. We conducted subgroup analyses in different populations. During the median 5.39 years follow-up, 373 participants, 286 males and 87 females, developed diabetes mellitus. After full adjustment for confounders, the baseline TG/HDL-C ratio positively correlated with the risk of diabetes (hazard ratio 1.19, 95% confidence interval 1.09–1.3), and smoothed curve fitting and two-stage linear regression analysis revealed a J-shaped relationship between baseline TG/HDL-C and T2DM. The inflection point for baseline TG/HDL-C was 0.35. baseline TG/HDL-C > 0.35 was positively associated with the development of T2DM (hazard ratio 1.2, 95% confidence interval 1.10–1.31). Subgroup analysis showed no significant differences in the effect between TG/HDL-C and T2DM in different populations. A J-shaped relationship was observed between baseline TG/HDL-C and T2DM risk in the Japanese population. When TG/HDL-C was higher than 0.35, there was a positive relationship between baseline TG/HDL-C and the incidence of diabetes mellitus. |
| first_indexed | 2024-04-09T22:58:23Z |
| format | Article |
| id | doaj.art-64a6ecd310c14e6a930494a153ce28d7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:58:23Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-64a6ecd310c14e6a930494a153ce28d72023-03-22T11:07:51ZengNature PortfolioScientific Reports2045-23222023-03-0113111010.1038/s41598-022-25585-5Association between triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in JapaneseHuijuan Wang0Changming Wang1Xiuping Xuan2Zhouni Xie3Yuanyuan Qiu4Huiping Qin5Zhong Xiaoning6Department of Respiratory, The First Affiliated Hospital, Guangxi Medical UniversityDepartment of Respiratory Medicine, Guilin People’s Hospital, The Fifth Affiliated Hospital of Guilin Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of General Medicine, Guilin People’s Hospital, The Fifth Affiliated Hospital of Guilin Medical UniversityDepartment of General Medicine, Guilin People’s Hospital, The Fifth Affiliated Hospital of Guilin Medical UniversityDepartment of Respiratory Medicine, Guilin People’s Hospital, The Fifth Affiliated Hospital of Guilin Medical UniversityDepartment of Respiratory, The First Affiliated Hospital, Guangxi Medical UniversityAbstract Abnormal lipid metabolism is known to increases the risk for metabolic diseases, such as type 2 diabetes mellitus(T2DM). The relationship between baseline ratio of triglyceride to HDL cholesterol (TG/HDL-C) and T2DM in Japanese adults was investigated in this study. Our secondary analysis included 8419 male and 7034 female Japanese subjects who were free of diabetes at baseline. The correlation between baseline TG/HDL-C and T2DM was analyzed by a proportional risk regression model, the nonlinear correlation between baseline TG/HDL-C and T2DM was analyzed by a generalized additive model (GAM), and the threshold effect analysis was performed by a segmented regression model. We conducted subgroup analyses in different populations. During the median 5.39 years follow-up, 373 participants, 286 males and 87 females, developed diabetes mellitus. After full adjustment for confounders, the baseline TG/HDL-C ratio positively correlated with the risk of diabetes (hazard ratio 1.19, 95% confidence interval 1.09–1.3), and smoothed curve fitting and two-stage linear regression analysis revealed a J-shaped relationship between baseline TG/HDL-C and T2DM. The inflection point for baseline TG/HDL-C was 0.35. baseline TG/HDL-C > 0.35 was positively associated with the development of T2DM (hazard ratio 1.2, 95% confidence interval 1.10–1.31). Subgroup analysis showed no significant differences in the effect between TG/HDL-C and T2DM in different populations. A J-shaped relationship was observed between baseline TG/HDL-C and T2DM risk in the Japanese population. When TG/HDL-C was higher than 0.35, there was a positive relationship between baseline TG/HDL-C and the incidence of diabetes mellitus.https://doi.org/10.1038/s41598-022-25585-5 |
| spellingShingle | Huijuan Wang Changming Wang Xiuping Xuan Zhouni Xie Yuanyuan Qiu Huiping Qin Zhong Xiaoning Association between triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in Japanese Scientific Reports |
| title | Association between triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in Japanese |
| title_full | Association between triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in Japanese |
| title_fullStr | Association between triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in Japanese |
| title_full_unstemmed | Association between triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in Japanese |
| title_short | Association between triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in Japanese |
| title_sort | association between triglyceride to high density lipoprotein cholesterol ratio and type 2 diabetes risk in japanese |
| url | https://doi.org/10.1038/s41598-022-25585-5 |
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