Sex difference in anti‐sperm antibodies
Abstract Background Some diseases have sex differences. There have been no reports on the relationship between anti‐sperm antibodies (ASA) and sex differences. Methods ASA are detected by sperm‐immobilization test using patients' sera in women. In men, the ASA testing is generally performed by...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Reproductive Medicine and Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rmb2.12477 |
| _version_ | 1797976009829515264 |
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| author | Hiroaki Shibahara Yuekun Chen Haruka Honda Yu Wakimoto Atsushi Fukui Akiko Hasegawa |
| author_facet | Hiroaki Shibahara Yuekun Chen Haruka Honda Yu Wakimoto Atsushi Fukui Akiko Hasegawa |
| author_sort | Hiroaki Shibahara |
| collection | DOAJ |
| description | Abstract Background Some diseases have sex differences. There have been no reports on the relationship between anti‐sperm antibodies (ASA) and sex differences. Methods ASA are detected by sperm‐immobilization test using patients' sera in women. In men, the ASA testing is generally performed by direct‐immunobead test. Main findings Sperm‐immobilizing antibodies in women inhibit sperm migration in their genital tract and exert inhibitory effects on fertilization. ASA bound to sperm surface in men also show inhibitory effect on sperm passage through cervical mucus. The fertilization rate of IVF significantly decreased when sperm were coated with higher numbers of ASA. For women with the antibodies, it is important to assess individual patients' SI50 titers. In patients with continuously high SI50 titers, pregnancy can be obtained only by IVF. For men with abnormal fertilizing ability by ASA, it is necessary to select intracytoplasmic sperm injection. Production of sperm‐immobilizing antibodies is likely to occur in women with particular HLA after exposure to sperm. The risk factors for ASA production in men are still controversial. Conclusion Attention to sex differences in specimens, test methods and the diagnosis of ASA should be paid. For patients with ASA, treatment strategies have been established by considering sex difference for each. |
| first_indexed | 2024-04-11T04:44:30Z |
| format | Article |
| id | doaj.art-64a795f36f3e440eb8469e4c98a8cb3c |
| institution | Directory Open Access Journal |
| issn | 1445-5781 1447-0578 |
| language | English |
| last_indexed | 2024-04-11T04:44:30Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj.art-64a795f36f3e440eb8469e4c98a8cb3c2022-12-27T13:54:58ZengWileyReproductive Medicine and Biology1445-57811447-05782022-01-01211n/an/a10.1002/rmb2.12477Sex difference in anti‐sperm antibodiesHiroaki Shibahara0Yuekun Chen1Haruka Honda2Yu Wakimoto3Atsushi Fukui4Akiko Hasegawa5Department of Obstetrics and Gynecology School of Medicine, Hyogo Medical University Nishinomiya JapanDepartment of Obstetrics and Gynecology School of Medicine, Hyogo Medical University Nishinomiya JapanDepartment of Obstetrics and Gynecology School of Medicine, Hyogo Medical University Nishinomiya JapanDepartment of Obstetrics and Gynecology School of Medicine, Hyogo Medical University Nishinomiya JapanDepartment of Obstetrics and Gynecology School of Medicine, Hyogo Medical University Nishinomiya JapanDepartment of Obstetrics and Gynecology School of Medicine, Hyogo Medical University Nishinomiya JapanAbstract Background Some diseases have sex differences. There have been no reports on the relationship between anti‐sperm antibodies (ASA) and sex differences. Methods ASA are detected by sperm‐immobilization test using patients' sera in women. In men, the ASA testing is generally performed by direct‐immunobead test. Main findings Sperm‐immobilizing antibodies in women inhibit sperm migration in their genital tract and exert inhibitory effects on fertilization. ASA bound to sperm surface in men also show inhibitory effect on sperm passage through cervical mucus. The fertilization rate of IVF significantly decreased when sperm were coated with higher numbers of ASA. For women with the antibodies, it is important to assess individual patients' SI50 titers. In patients with continuously high SI50 titers, pregnancy can be obtained only by IVF. For men with abnormal fertilizing ability by ASA, it is necessary to select intracytoplasmic sperm injection. Production of sperm‐immobilizing antibodies is likely to occur in women with particular HLA after exposure to sperm. The risk factors for ASA production in men are still controversial. Conclusion Attention to sex differences in specimens, test methods and the diagnosis of ASA should be paid. For patients with ASA, treatment strategies have been established by considering sex difference for each.https://doi.org/10.1002/rmb2.12477anti‐sperm antibodyautoimmune diseasesex differencesperm‐immobilizing antibody |
| spellingShingle | Hiroaki Shibahara Yuekun Chen Haruka Honda Yu Wakimoto Atsushi Fukui Akiko Hasegawa Sex difference in anti‐sperm antibodies Reproductive Medicine and Biology anti‐sperm antibody autoimmune disease sex difference sperm‐immobilizing antibody |
| title | Sex difference in anti‐sperm antibodies |
| title_full | Sex difference in anti‐sperm antibodies |
| title_fullStr | Sex difference in anti‐sperm antibodies |
| title_full_unstemmed | Sex difference in anti‐sperm antibodies |
| title_short | Sex difference in anti‐sperm antibodies |
| title_sort | sex difference in anti sperm antibodies |
| topic | anti‐sperm antibody autoimmune disease sex difference sperm‐immobilizing antibody |
| url | https://doi.org/10.1002/rmb2.12477 |
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