DL-3-n-butylphthalide promotes hippocampal neurogenesis and reduces mossy fiber sprouting in chronic temporal lobe epilepsy rats

DL-3-n-butylphthalide promotes hippocampal neurogenesis and reduces mossy fiber sprouting in chronic temporal lobe epilepsy rats

Abstract Background A decrease in hippocampal neurogenesis is considered an important cause of cognitive impairment, while changes in mossy fiber sprouting are closely related to development of spontaneous recurrent seizures in chronic temporal lobe epilepsy (TLE). Racemic l-3-n-butylphthalide (DL-N...

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Bibliographic Details
Main Authors: Shanshan Zhao, Fangxi Liu, Wei Shi, Jialu Wang, Zhike Zhou, Xiaoqian Zhang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Neurology
Subjects:
DL-3-n-butylphthalide
Temporal lobe epilepsy
Neurogenesis
Cognition
Online Access:https://doi.org/10.1186/s12883-021-02516-x

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