Giant-cell tumor: analysis on the importance of early diagnosis and the epidemiological profile
ABSTRACT OBJECTIVE: This study aimed to ascertain the relationship between early diagnosis of giant-cell tumors (GCT) and their prognosis, by correlating the time of symptom onset with the staging of the injury (through the Campanacci classification at the time of diagnosis), and with the type of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2016-02-01
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| Series: | Revista Brasileira de Ortopedia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000100058&lng=en&tlng=en |
| _version_ | 1797225618890293248 |
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| author | Diego Firmino de Carvalho Diniz Ferraz César Augusto Torres dos Santos Victor Hugo Farias Costa Antônio Marcelo Gonçalves Souza Paulo Rogerio Gomes Lima |
| author_facet | Diego Firmino de Carvalho Diniz Ferraz César Augusto Torres dos Santos Victor Hugo Farias Costa Antônio Marcelo Gonçalves Souza Paulo Rogerio Gomes Lima |
| author_sort | Diego Firmino de Carvalho Diniz Ferraz |
| collection | DOAJ |
| description | ABSTRACT OBJECTIVE: This study aimed to ascertain the relationship between early diagnosis of giant-cell tumors (GCT) and their prognosis, by correlating the time of symptom onset with the staging of the injury (through the Campanacci classification at the time of diagnosis), and with the type of treatment. The secondary objective of the study was to outline the epidemiological profile of patients with GCT in the region where the data were gathered, and to compare them with data in the literature. METHODS: The authors present an evaluation on 61 patients diagnosed with bone GCT, with regard to the site of involvement, age, initial symptoms, time of symptom onset, classification and type of treatment, among patients attended between May 1994 and August 2009. RESULTS: The threshold indicated as the limit for Campanacci stage I tumors to be the commonest diagnosis, with a 98.2% chance that the treatment would be non-aggressive, was 2 months after symptom onset. This finding was statistically significant (p = 0.017). Every additional month increased the chance that a patient would be diagnosed with an advanced-stage tumor by 10.94%, in relation to the chances of having the other two stages of the tumor. CONCLUSION: The study result not only suggests that the alternative hypothesis that the earlier the diagnosis of GCT is, the less severe the lesion will be, has been confirmed; but also especially predicts the relationship between the time of symptom appearance and the severity of the tumor. |
| first_indexed | 2024-03-08T07:20:19Z |
| format | Article |
| id | doaj.art-64a8bf24dba64abda26c1f40a65719b7 |
| institution | Directory Open Access Journal |
| issn | 1982-4378 |
| language | English |
| last_indexed | 2024-04-24T14:11:53Z |
| publishDate | 2016-02-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Revista Brasileira de Ortopedia |
| spelling | doaj.art-64a8bf24dba64abda26c1f40a65719b72024-04-03T09:02:01ZengThieme Revinter Publicações Ltda.Revista Brasileira de Ortopedia1982-43782016-02-01511586210.1016/j.rboe.2015.12.012S0102-36162016000100058Giant-cell tumor: analysis on the importance of early diagnosis and the epidemiological profileDiego Firmino de Carvalho Diniz FerrazCésar Augusto Torres dos SantosVictor Hugo Farias CostaAntônio Marcelo Gonçalves SouzaPaulo Rogerio Gomes LimaABSTRACT OBJECTIVE: This study aimed to ascertain the relationship between early diagnosis of giant-cell tumors (GCT) and their prognosis, by correlating the time of symptom onset with the staging of the injury (through the Campanacci classification at the time of diagnosis), and with the type of treatment. The secondary objective of the study was to outline the epidemiological profile of patients with GCT in the region where the data were gathered, and to compare them with data in the literature. METHODS: The authors present an evaluation on 61 patients diagnosed with bone GCT, with regard to the site of involvement, age, initial symptoms, time of symptom onset, classification and type of treatment, among patients attended between May 1994 and August 2009. RESULTS: The threshold indicated as the limit for Campanacci stage I tumors to be the commonest diagnosis, with a 98.2% chance that the treatment would be non-aggressive, was 2 months after symptom onset. This finding was statistically significant (p = 0.017). Every additional month increased the chance that a patient would be diagnosed with an advanced-stage tumor by 10.94%, in relation to the chances of having the other two stages of the tumor. CONCLUSION: The study result not only suggests that the alternative hypothesis that the earlier the diagnosis of GCT is, the less severe the lesion will be, has been confirmed; but also especially predicts the relationship between the time of symptom appearance and the severity of the tumor.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000100058&lng=en&tlng=enTumores de células gigantes/diagnósticoTumores de células gigantes/epidemiologiaTumores de células gigantes/terapia |
| spellingShingle | Diego Firmino de Carvalho Diniz Ferraz César Augusto Torres dos Santos Victor Hugo Farias Costa Antônio Marcelo Gonçalves Souza Paulo Rogerio Gomes Lima Giant-cell tumor: analysis on the importance of early diagnosis and the epidemiological profile Revista Brasileira de Ortopedia Tumores de células gigantes/diagnóstico Tumores de células gigantes/epidemiologia Tumores de células gigantes/terapia |
| title | Giant-cell tumor: analysis on the importance of early diagnosis and the epidemiological profile |
| title_full | Giant-cell tumor: analysis on the importance of early diagnosis and the epidemiological profile |
| title_fullStr | Giant-cell tumor: analysis on the importance of early diagnosis and the epidemiological profile |
| title_full_unstemmed | Giant-cell tumor: analysis on the importance of early diagnosis and the epidemiological profile |
| title_short | Giant-cell tumor: analysis on the importance of early diagnosis and the epidemiological profile |
| title_sort | giant cell tumor analysis on the importance of early diagnosis and the epidemiological profile |
| topic | Tumores de células gigantes/diagnóstico Tumores de células gigantes/epidemiologia Tumores de células gigantes/terapia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162016000100058&lng=en&tlng=en |
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