Plectin in Cancer: From Biomarker to Therapeutic Target
The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities contributing to tumorigenesis, including cancer cell proliferation, adhesion, migration, invasion, and signal transductio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/9/2246 |
| _version_ | 1797519899135836160 |
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| author | Samantha M. Perez Lindsey T. Brinton Kimberly A. Kelly |
| author_facet | Samantha M. Perez Lindsey T. Brinton Kimberly A. Kelly |
| author_sort | Samantha M. Perez |
| collection | DOAJ |
| description | The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities contributing to tumorigenesis, including cancer cell proliferation, adhesion, migration, invasion, and signal transduction. Evidence shows that beyond plectin’s diverse protein interactome, its cancer-specific mislocalization to the cell surface enables its function as a potent oncoprotein. As such, therapeutic targeting of plectin, its protein interactors, and, in particular, cancer-specific plectin (CSP) presents an attractive opportunity to impede carcinogenesis directly. Here, we report on plectin’s differential gene and protein expression in cancer, explore its mutational profile, and discuss the current understanding of plectin’s and CSP’s biological function in cancer. Moreover, we review the landscape of plectin as a prognostic marker, diagnostic biomarker, and target for imaging and therapeutic modalities. We highlight how, beyond their respective biological importance, plectin’s common overexpression in cancer and CSP’s cancer-specific bioavailability underscore their potential as high-value druggable targets. We discuss how recent evidence of the potent anti-cancer effects of CSP therapeutic targeting opens the door for cell-surface mislocalized proteins as novel therapeutic targets. |
| first_indexed | 2024-03-10T07:49:19Z |
| format | Article |
| id | doaj.art-64a951f22aba41bf937549d896734664 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:49:19Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-64a951f22aba41bf937549d8967346642023-11-22T12:23:07ZengMDPI AGCells2073-44092021-08-01109224610.3390/cells10092246Plectin in Cancer: From Biomarker to Therapeutic TargetSamantha M. Perez0Lindsey T. Brinton1Kimberly A. Kelly2Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USAZielBio, Inc., Charlottesville, VA 22903, USADepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USAThe cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities contributing to tumorigenesis, including cancer cell proliferation, adhesion, migration, invasion, and signal transduction. Evidence shows that beyond plectin’s diverse protein interactome, its cancer-specific mislocalization to the cell surface enables its function as a potent oncoprotein. As such, therapeutic targeting of plectin, its protein interactors, and, in particular, cancer-specific plectin (CSP) presents an attractive opportunity to impede carcinogenesis directly. Here, we report on plectin’s differential gene and protein expression in cancer, explore its mutational profile, and discuss the current understanding of plectin’s and CSP’s biological function in cancer. Moreover, we review the landscape of plectin as a prognostic marker, diagnostic biomarker, and target for imaging and therapeutic modalities. We highlight how, beyond their respective biological importance, plectin’s common overexpression in cancer and CSP’s cancer-specific bioavailability underscore their potential as high-value druggable targets. We discuss how recent evidence of the potent anti-cancer effects of CSP therapeutic targeting opens the door for cell-surface mislocalized proteins as novel therapeutic targets.https://www.mdpi.com/2073-4409/10/9/2246plectinbiomarkerimaging agentdrug deliverytherapeutic |
| spellingShingle | Samantha M. Perez Lindsey T. Brinton Kimberly A. Kelly Plectin in Cancer: From Biomarker to Therapeutic Target Cells plectin biomarker imaging agent drug delivery therapeutic |
| title | Plectin in Cancer: From Biomarker to Therapeutic Target |
| title_full | Plectin in Cancer: From Biomarker to Therapeutic Target |
| title_fullStr | Plectin in Cancer: From Biomarker to Therapeutic Target |
| title_full_unstemmed | Plectin in Cancer: From Biomarker to Therapeutic Target |
| title_short | Plectin in Cancer: From Biomarker to Therapeutic Target |
| title_sort | plectin in cancer from biomarker to therapeutic target |
| topic | plectin biomarker imaging agent drug delivery therapeutic |
| url | https://www.mdpi.com/2073-4409/10/9/2246 |
| work_keys_str_mv | AT samanthamperez plectinincancerfrombiomarkertotherapeutictarget AT lindseytbrinton plectinincancerfrombiomarkertotherapeutictarget AT kimberlyakelly plectinincancerfrombiomarkertotherapeutictarget |