The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents
Abstract Background In sub-Saharan Africa, acute respiratory infections (ARI), acute gastrointestinal infections (GI) and acute febrile disease of unknown cause (AFDUC) have a large disease burden, especially among children, while respective aetiologies often remain unresolved. The need for robust i...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-021-06238-w |
| _version_ | 1818836783549382656 |
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| author | Grit Schubert Vincent Achi Steve Ahuka Essia Belarbi Ouattara Bourhaima Tim Eckmanns Siobhan Johnstone Firmin Kabore Ouffoue Kra Adriano Mendes Abdoul-Salam Ouedraogo Armel Poda Arsène Satouro Some Sara Tomczyk Emmanuel Couacy-Hymann Jean-Marie Kayembe Nicolas Meda Jean-Jacques Muyembe Tamfum Soumeya Ouangraoua Nicola Page Marietjie Venter Fabian H. Leendertz Chantal Akoua-Koffi the ANDEMIA consortium |
| author_facet | Grit Schubert Vincent Achi Steve Ahuka Essia Belarbi Ouattara Bourhaima Tim Eckmanns Siobhan Johnstone Firmin Kabore Ouffoue Kra Adriano Mendes Abdoul-Salam Ouedraogo Armel Poda Arsène Satouro Some Sara Tomczyk Emmanuel Couacy-Hymann Jean-Marie Kayembe Nicolas Meda Jean-Jacques Muyembe Tamfum Soumeya Ouangraoua Nicola Page Marietjie Venter Fabian H. Leendertz Chantal Akoua-Koffi the ANDEMIA consortium |
| author_sort | Grit Schubert |
| collection | DOAJ |
| description | Abstract Background In sub-Saharan Africa, acute respiratory infections (ARI), acute gastrointestinal infections (GI) and acute febrile disease of unknown cause (AFDUC) have a large disease burden, especially among children, while respective aetiologies often remain unresolved. The need for robust infectious disease surveillance to detect emerging pathogens along with common human pathogens has been highlighted by the ongoing novel coronavirus disease 2019 (COVID-19) pandemic. The African Network for Improved Diagnostics, Epidemiology and Management of Common Infectious Agents (ANDEMIA) is a sentinel surveillance study on the aetiology and clinical characteristics of ARI, GI and AFDUC in sub-Saharan Africa. Methods ANDEMIA includes 12 urban and rural health care facilities in four African countries (Côte d’Ivoire, Burkina Faso, Democratic Republic of the Congo and Republic of South Africa). It was piloted in 2018 in Côte d’Ivoire and the initial phase will run from 2019 to 2021. Case definitions for ARI, GI and AFDUC were established, as well as syndrome-specific sampling algorithms including the collection of blood, naso- and oropharyngeal swabs and stool. Samples are tested using comprehensive diagnostic protocols, ranging from classic bacteriology and antimicrobial resistance screening to multiplex real-time polymerase chain reaction (PCR) systems and High Throughput Sequencing. In March 2020, PCR testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and analysis of full genomic information was included in the study. Standardised questionnaires collect relevant clinical, demographic, socio-economic and behavioural data for epidemiologic analyses. Controls are enrolled over a 12-month period for a nested case-control study. Data will be assessed descriptively and aetiologies will be evaluated using a latent class analysis among cases. Among cases and controls, an integrated analytic approach using logistic regression and Bayesian estimation will be employed to improve the assessment of aetiology and associated risk factors. Discussion ANDEMIA aims to expand our understanding of ARI, GI and AFDUC aetiologies in sub-Saharan Africa using a comprehensive laboratory diagnostics strategy. It will foster early detection of emerging threats and continued monitoring of important common pathogens. The network collaboration will be strengthened and site diagnostic capacities will be reinforced to improve quality management and patient care. |
| first_indexed | 2024-12-19T03:12:06Z |
| format | Article |
| id | doaj.art-64aa169eddf74744b0eccfc885b4551d |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-19T03:12:06Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-64aa169eddf74744b0eccfc885b4551d2022-12-21T20:37:58ZengBMCBMC Infectious Diseases1471-23342021-06-0121111010.1186/s12879-021-06238-wThe African Network for Improved Diagnostics, Epidemiology and Management of common infectious AgentsGrit Schubert0Vincent Achi1Steve Ahuka2Essia Belarbi3Ouattara Bourhaima4Tim Eckmanns5Siobhan Johnstone6Firmin Kabore7Ouffoue Kra8Adriano Mendes9Abdoul-Salam Ouedraogo10Armel Poda11Arsène Satouro Some12Sara Tomczyk13Emmanuel Couacy-Hymann14Jean-Marie Kayembe15Nicolas Meda16Jean-Jacques Muyembe Tamfum17Soumeya Ouangraoua18Nicola Page19Marietjie Venter20Fabian H. Leendertz21Chantal Akoua-Koffi22the ANDEMIA consortiumRobert Koch-InstituteCentre Hospitalier Universitaire BouakéInstitut National de la Recherche BiomédicaleRobert Koch-InstituteCentre Hospitalier Universitaire BouakéRobert Koch-InstituteNational Institute for Communicable DiseasesCentre MurazCentre Hospitalier Universitaire BouakéUniversity of PretoriaCentre Hospitalier Universitaire Sourô Sanou de Bobo-DioulassoCentre Hospitalier Universitaire Sourô Sanou de Bobo-DioulassoCentre MurazRobert Koch-InstituteLaboratoire National d’Appui au Développement Agricole / Laboratoire Central de Pathologie AnimaleHôpital Universitaire/Université de KinshasaCentre MurazInstitut National de la Recherche BiomédicaleCentre MurazNational Institute for Communicable DiseasesUniversity of PretoriaRobert Koch-InstituteCentre Hospitalier Universitaire BouakéAbstract Background In sub-Saharan Africa, acute respiratory infections (ARI), acute gastrointestinal infections (GI) and acute febrile disease of unknown cause (AFDUC) have a large disease burden, especially among children, while respective aetiologies often remain unresolved. The need for robust infectious disease surveillance to detect emerging pathogens along with common human pathogens has been highlighted by the ongoing novel coronavirus disease 2019 (COVID-19) pandemic. The African Network for Improved Diagnostics, Epidemiology and Management of Common Infectious Agents (ANDEMIA) is a sentinel surveillance study on the aetiology and clinical characteristics of ARI, GI and AFDUC in sub-Saharan Africa. Methods ANDEMIA includes 12 urban and rural health care facilities in four African countries (Côte d’Ivoire, Burkina Faso, Democratic Republic of the Congo and Republic of South Africa). It was piloted in 2018 in Côte d’Ivoire and the initial phase will run from 2019 to 2021. Case definitions for ARI, GI and AFDUC were established, as well as syndrome-specific sampling algorithms including the collection of blood, naso- and oropharyngeal swabs and stool. Samples are tested using comprehensive diagnostic protocols, ranging from classic bacteriology and antimicrobial resistance screening to multiplex real-time polymerase chain reaction (PCR) systems and High Throughput Sequencing. In March 2020, PCR testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and analysis of full genomic information was included in the study. Standardised questionnaires collect relevant clinical, demographic, socio-economic and behavioural data for epidemiologic analyses. Controls are enrolled over a 12-month period for a nested case-control study. Data will be assessed descriptively and aetiologies will be evaluated using a latent class analysis among cases. Among cases and controls, an integrated analytic approach using logistic regression and Bayesian estimation will be employed to improve the assessment of aetiology and associated risk factors. Discussion ANDEMIA aims to expand our understanding of ARI, GI and AFDUC aetiologies in sub-Saharan Africa using a comprehensive laboratory diagnostics strategy. It will foster early detection of emerging threats and continued monitoring of important common pathogens. The network collaboration will be strengthened and site diagnostic capacities will be reinforced to improve quality management and patient care.https://doi.org/10.1186/s12879-021-06238-wAcute respiratory tract infectionsAcute gastrointestinal infectionsAcute febrile disease of unknown causeSentinel surveillanceSub-Saharan AfricaAetiologies |
| spellingShingle | Grit Schubert Vincent Achi Steve Ahuka Essia Belarbi Ouattara Bourhaima Tim Eckmanns Siobhan Johnstone Firmin Kabore Ouffoue Kra Adriano Mendes Abdoul-Salam Ouedraogo Armel Poda Arsène Satouro Some Sara Tomczyk Emmanuel Couacy-Hymann Jean-Marie Kayembe Nicolas Meda Jean-Jacques Muyembe Tamfum Soumeya Ouangraoua Nicola Page Marietjie Venter Fabian H. Leendertz Chantal Akoua-Koffi the ANDEMIA consortium The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents BMC Infectious Diseases Acute respiratory tract infections Acute gastrointestinal infections Acute febrile disease of unknown cause Sentinel surveillance Sub-Saharan Africa Aetiologies |
| title | The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents |
| title_full | The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents |
| title_fullStr | The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents |
| title_full_unstemmed | The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents |
| title_short | The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents |
| title_sort | african network for improved diagnostics epidemiology and management of common infectious agents |
| topic | Acute respiratory tract infections Acute gastrointestinal infections Acute febrile disease of unknown cause Sentinel surveillance Sub-Saharan Africa Aetiologies |
| url | https://doi.org/10.1186/s12879-021-06238-w |
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