Mechanistic Insights into the Link between Obesity and Prostate Cancer
Obesity is a pandemic of increasing worldwide prevalence. There is evidence of an association between obesity and the risk of prostate cancer from observational studies, and different biologic mechanisms have been proposed. The chronic low-level inflammation within the adipose tissue in obesity resu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/8/3935 |
| _version_ | 1797538057775218688 |
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| author | Bamidele A. Adesunloye |
| author_facet | Bamidele A. Adesunloye |
| author_sort | Bamidele A. Adesunloye |
| collection | DOAJ |
| description | Obesity is a pandemic of increasing worldwide prevalence. There is evidence of an association between obesity and the risk of prostate cancer from observational studies, and different biologic mechanisms have been proposed. The chronic low-level inflammation within the adipose tissue in obesity results in oxidative stress, activation of inflammatory cytokines, deregulation of adipokines signaling, and increased circulating levels of insulin and insulin-like growth factors (IGF). These mechanisms may be involved in epithelial to mesenchymal transformation into a malignant phenotype that promotes invasiveness, aggressiveness, and metastatic potential of prostate cancer. A thorough understanding of these mechanisms may be valuable in the development of effective prostate cancer prevention strategies and treatments. This review provides an overview of these mechanisms. |
| first_indexed | 2024-03-10T12:25:04Z |
| format | Article |
| id | doaj.art-64abd25f11164769877945ddd44a198d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:25:04Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-64abd25f11164769877945ddd44a198d2023-11-21T15:04:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228393510.3390/ijms22083935Mechanistic Insights into the Link between Obesity and Prostate CancerBamidele A. Adesunloye0Cancer Treatment Centers of America, 600 Celebrate Life Parkway, Newnan, GA 30265, USAObesity is a pandemic of increasing worldwide prevalence. There is evidence of an association between obesity and the risk of prostate cancer from observational studies, and different biologic mechanisms have been proposed. The chronic low-level inflammation within the adipose tissue in obesity results in oxidative stress, activation of inflammatory cytokines, deregulation of adipokines signaling, and increased circulating levels of insulin and insulin-like growth factors (IGF). These mechanisms may be involved in epithelial to mesenchymal transformation into a malignant phenotype that promotes invasiveness, aggressiveness, and metastatic potential of prostate cancer. A thorough understanding of these mechanisms may be valuable in the development of effective prostate cancer prevention strategies and treatments. This review provides an overview of these mechanisms.https://www.mdpi.com/1422-0067/22/8/3935obesityprostate canceradipose tissuechronic inflammationcytokinesadipokines |
| spellingShingle | Bamidele A. Adesunloye Mechanistic Insights into the Link between Obesity and Prostate Cancer International Journal of Molecular Sciences obesity prostate cancer adipose tissue chronic inflammation cytokines adipokines |
| title | Mechanistic Insights into the Link between Obesity and Prostate Cancer |
| title_full | Mechanistic Insights into the Link between Obesity and Prostate Cancer |
| title_fullStr | Mechanistic Insights into the Link between Obesity and Prostate Cancer |
| title_full_unstemmed | Mechanistic Insights into the Link between Obesity and Prostate Cancer |
| title_short | Mechanistic Insights into the Link between Obesity and Prostate Cancer |
| title_sort | mechanistic insights into the link between obesity and prostate cancer |
| topic | obesity prostate cancer adipose tissue chronic inflammation cytokines adipokines |
| url | https://www.mdpi.com/1422-0067/22/8/3935 |
| work_keys_str_mv | AT bamideleaadesunloye mechanisticinsightsintothelinkbetweenobesityandprostatecancer |