Screening for tuberculosis and prediction of disease in Portuguese healthcare workers
<p>Abstract</p> <p>Introduction</p> <p>Results of systematic screening of healthcare workers (HCWs) for tuberculosis (TB) with the tuberculin skin test (TST) and interferon-γ release assays (IGRA) in a Portuguese hospital from 2007 to 2010 are reported.</p> <p&...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-06-01
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| Series: | Journal of Occupational Medicine and Toxicology |
| Online Access: | http://www.occup-med.com/content/6/1/19 |
| _version_ | 1811184141733986304 |
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| author | Ringshausen Felix C Silva Rui Torres Costa José Nienhaus Albert |
| author_facet | Ringshausen Felix C Silva Rui Torres Costa José Nienhaus Albert |
| author_sort | Ringshausen Felix C |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Results of systematic screening of healthcare workers (HCWs) for tuberculosis (TB) with the tuberculin skin test (TST) and interferon-γ release assays (IGRA) in a Portuguese hospital from 2007 to 2010 are reported.</p> <p>Methods</p> <p>All HCWs are offered screening for TB. Screening is repeated depending on risk assessment. TST and QuantiFERON Gold In-Tube (QFT) are used simultaneously. X-ray is performed when TST is > 10 mm, IGRA is positive or typical symptoms exist.</p> <p>Results</p> <p>The cohort comprises 2,889 HCWs. TST and IGRA were positive in 29.5%, TST-positive but IGRA-negative results were apparent in 43.4%. Active TB was diagnosed in twelve HCWs - eight cases were detected during screening and four cases were predicted by IGRA as well as by TST. However, the progression rate in IGRA-positive was higher than in TST-positive HCWs (0.4% vs. 0.2%, p-value 0.06).</p> <p>Conclusions</p> <p>The TB burden in this cohort was high (129.8 per 100,000 HCWs). However, the progression to active TB after a positive TST or positive IGRA was considerably lower than that reported in literature for close contacts in low-incidence countries. This may indicate that old LTBI prevails in these HCWs.</p> |
| first_indexed | 2024-04-11T13:08:13Z |
| format | Article |
| id | doaj.art-64ac9ff00e5e442e8dacb3699ae82a99 |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-04-11T13:08:13Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-64ac9ff00e5e442e8dacb3699ae82a992022-12-22T04:22:39ZengBMCJournal of Occupational Medicine and Toxicology1745-66732011-06-01611910.1186/1745-6673-6-19Screening for tuberculosis and prediction of disease in Portuguese healthcare workersRingshausen Felix CSilva RuiTorres Costa JoséNienhaus Albert<p>Abstract</p> <p>Introduction</p> <p>Results of systematic screening of healthcare workers (HCWs) for tuberculosis (TB) with the tuberculin skin test (TST) and interferon-γ release assays (IGRA) in a Portuguese hospital from 2007 to 2010 are reported.</p> <p>Methods</p> <p>All HCWs are offered screening for TB. Screening is repeated depending on risk assessment. TST and QuantiFERON Gold In-Tube (QFT) are used simultaneously. X-ray is performed when TST is > 10 mm, IGRA is positive or typical symptoms exist.</p> <p>Results</p> <p>The cohort comprises 2,889 HCWs. TST and IGRA were positive in 29.5%, TST-positive but IGRA-negative results were apparent in 43.4%. Active TB was diagnosed in twelve HCWs - eight cases were detected during screening and four cases were predicted by IGRA as well as by TST. However, the progression rate in IGRA-positive was higher than in TST-positive HCWs (0.4% vs. 0.2%, p-value 0.06).</p> <p>Conclusions</p> <p>The TB burden in this cohort was high (129.8 per 100,000 HCWs). However, the progression to active TB after a positive TST or positive IGRA was considerably lower than that reported in literature for close contacts in low-incidence countries. This may indicate that old LTBI prevails in these HCWs.</p>http://www.occup-med.com/content/6/1/19 |
| spellingShingle | Ringshausen Felix C Silva Rui Torres Costa José Nienhaus Albert Screening for tuberculosis and prediction of disease in Portuguese healthcare workers Journal of Occupational Medicine and Toxicology |
| title | Screening for tuberculosis and prediction of disease in Portuguese healthcare workers |
| title_full | Screening for tuberculosis and prediction of disease in Portuguese healthcare workers |
| title_fullStr | Screening for tuberculosis and prediction of disease in Portuguese healthcare workers |
| title_full_unstemmed | Screening for tuberculosis and prediction of disease in Portuguese healthcare workers |
| title_short | Screening for tuberculosis and prediction of disease in Portuguese healthcare workers |
| title_sort | screening for tuberculosis and prediction of disease in portuguese healthcare workers |
| url | http://www.occup-med.com/content/6/1/19 |
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