TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent Gliomas
5-Aminolevulinic acid (5-ALA) is a fluorescent dye that after metabolization to Protoporphyrin IX (PpIX) by the heme biosynthesis pathway typically leads to visible fluorescence in WHO grade IV but not grade II gliomas. The exact mechanism for high PpIX levels in WHO grade IV gliomas and low PpIX le...
Main Authors: | Mario Mischkulnig, Barbara Kiesel, Daniela Lötsch, Thomas Roetzer, Martin Borkovec, Lisa I. Wadiura, Petra A. Mercea, Florian J. Jaklin, Shawn Hervey-Jumper, Karl Roessler, Mitchel S. Berger, Georg Widhalm, Friedrich Erhart |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-07-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/12/8/2043 |
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