Synthesis of some 2-substituted pyrrolidine alkaloid analogues: N-benzyl-2-(5-substituted 1,3,4-oxadiazolyl) pyrrolidine derivatives and pharmacological screening

Synthesis of some 2-substituted pyrrolidine alkaloid analogues: N-benzyl-2-(5-substituted 1,3,4-oxadiazolyl) pyrrolidine derivatives and pharmacological screening

Six of N-benzyl-2-(5-substituted 1,3,4-oxadiazolyl) pyrrolidine derivatives 5(a-f) were synthesized from l-proline and characterized by IR, 1H NMR, 13C NMR, and GC–MS. All compounds were tested for antioxidant activity in vitro by the DPPH method. The decrease in absorption of the reaction mixture i...

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Bibliographic Details
Main Authors: Lemia Amarouche, Mohammed Amine Mehdid, Fawzia Taieb Brahimi, Fatima Belkhadem, Mohamed Karmaoui, Adil A. Othman
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Journal of Saudi Chemical Society
Subjects:
N-benzyl-2-pyrrolidine
Alkaloids analogues
1,3,4-Oxadiazol
Antioxidant activity
Antibacterial activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610322000308

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http://www.sciencedirect.com/science/article/pii/S1319610322000308

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