EVALUATION OF VENTILATION-PERFUSION RATIO IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Objective: To study ventilation-perfusion ratio (VPR) in patients with chronic obstructive pulmonary disease (COPD) using method of volumetric capnography. Methods: 35 patients with COPD II-IV stages and 17 volunteers without pathology of the respiratory system (control group) were examined. Usin...
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| Format: | Article |
| Language: | English |
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Avicenna Tajik State Medical University
2021-03-01
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| Series: | Паёми Сино |
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| Online Access: | https://doi.org/10.25005/2074-0581-2021-23-1-25-31 |
| _version_ | 1797803325920378880 |
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| author | T.A. MIROSHKINA S .A. SHUSTOVA I .B. PONOMARYOVA |
| author_facet | T.A. MIROSHKINA S .A. SHUSTOVA I .B. PONOMARYOVA |
| author_sort | T.A. MIROSHKINA |
| collection | DOAJ |
| description | Objective: To study ventilation-perfusion ratio (VPR) in patients with chronic obstructive pulmonary disease (COPD) using method of volumetric capnography.
Methods: 35 patients with COPD II-IV stages and 17 volunteers without pathology of the respiratory system (control group) were examined. Using SpiroScout (Ganshorn, Germany) with built-in function of volumetric capnography, spirography and volumetric capnography were implemented. Symptoms in patients with COPD were evaluated using mMRC and CAT.
Results: Statistically significant differences between the patients with COPD and the control group were identified in a number of parameters of volumetric capnography characterizing VPR. VDBohr, VDalv and their ratio to VT in patients with COPD were higher than in individuals of the control group (VDBohr – 361 [299-486] and 280 [215-463] ml, p=0.042; VDBohr/VT – 0.43 [0.40-0.51] and 0.35 [0.31-0.44], p=0.001; VDalv – 211 [142-290] and 81 [49.5-244.5] ml, p=0.012; VDalv/VT – 0.24 [0.20-0.34] and 0.13 [0.08-0.23], p=0.001). The slope of the 2nd phase of the capnogram in COPD was more smooth (dMM/dV2 – 2.0 [1.7-2.7] and 2.5 [2.2-3.2] g/mol×l, respectively; p=0.013), and the slope of the 3rd phase was steeper than in the individuals without pathology of the respiratory system (dMM/dV3 – 0.38 [0.29-0.51] and 0.22 [0.13-0.34] g/mol×l, respectively; p<0.001). Angle α in the group with COPD was increased in comparison with the control group (136
Conclusion: The conducted study identified derangement of VPR in patients with COPD. Volumetric capnography is an easy-to-use technique that allows evaluating VPR. |
| first_indexed | 2024-03-13T05:19:08Z |
| format | Article |
| id | doaj.art-64addee8e84542c79d93d0b5ff631727 |
| institution | Directory Open Access Journal |
| issn | 2074-0581 2959-6327 |
| language | English |
| last_indexed | 2024-03-13T05:19:08Z |
| publishDate | 2021-03-01 |
| publisher | Avicenna Tajik State Medical University |
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| series | Паёми Сино |
| spelling | doaj.art-64addee8e84542c79d93d0b5ff6317272023-06-15T16:34:08ZengAvicenna Tajik State Medical UniversityПаёми Сино2074-05812959-63272021-03-01231253110.25005/2074-0581-2021-23-1-25-31EVALUATION OF VENTILATION-PERFUSION RATIO IN CHRONIC OBSTRUCTIVE PULMONARY DISEASET.A. MIROSHKINA0S .A. SHUSTOVA1I .B. PONOMARYOVA2Department of Pathophysiology, Ryazan State Medical University named after Academician I .P. Pavlov, Ryazan, Russian FederationDepartment of Pathophysiology, Ryazan State Medical University named after Academician I .P. Pavlov, Ryazan, Russian FederationDepartment of Faculty Therapy with Course of Therapy, Faculty of Continuing Professional Education, Ryazan State Medical University named after Academician I .P. Pavlov, Ryazan, Russian FederationObjective: To study ventilation-perfusion ratio (VPR) in patients with chronic obstructive pulmonary disease (COPD) using method of volumetric capnography. Methods: 35 patients with COPD II-IV stages and 17 volunteers without pathology of the respiratory system (control group) were examined. Using SpiroScout (Ganshorn, Germany) with built-in function of volumetric capnography, spirography and volumetric capnography were implemented. Symptoms in patients with COPD were evaluated using mMRC and CAT. Results: Statistically significant differences between the patients with COPD and the control group were identified in a number of parameters of volumetric capnography characterizing VPR. VDBohr, VDalv and their ratio to VT in patients with COPD were higher than in individuals of the control group (VDBohr – 361 [299-486] and 280 [215-463] ml, p=0.042; VDBohr/VT – 0.43 [0.40-0.51] and 0.35 [0.31-0.44], p=0.001; VDalv – 211 [142-290] and 81 [49.5-244.5] ml, p=0.012; VDalv/VT – 0.24 [0.20-0.34] and 0.13 [0.08-0.23], p=0.001). The slope of the 2nd phase of the capnogram in COPD was more smooth (dMM/dV2 – 2.0 [1.7-2.7] and 2.5 [2.2-3.2] g/mol×l, respectively; p=0.013), and the slope of the 3rd phase was steeper than in the individuals without pathology of the respiratory system (dMM/dV3 – 0.38 [0.29-0.51] and 0.22 [0.13-0.34] g/mol×l, respectively; p<0.001). Angle α in the group with COPD was increased in comparison with the control group (136 Conclusion: The conducted study identified derangement of VPR in patients with COPD. Volumetric capnography is an easy-to-use technique that allows evaluating VPR.https://doi.org/10.25005/2074-0581-2021-23-1-25-31ventilation-perfusion ratiodead spacechronic obstructive pulmonary diseasevolumetric capnography. |
| spellingShingle | T.A. MIROSHKINA S .A. SHUSTOVA I .B. PONOMARYOVA EVALUATION OF VENTILATION-PERFUSION RATIO IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE Паёми Сино ventilation-perfusion ratio dead space chronic obstructive pulmonary disease volumetric capnography. |
| title | EVALUATION OF VENTILATION-PERFUSION RATIO IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full | EVALUATION OF VENTILATION-PERFUSION RATIO IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_fullStr | EVALUATION OF VENTILATION-PERFUSION RATIO IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full_unstemmed | EVALUATION OF VENTILATION-PERFUSION RATIO IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_short | EVALUATION OF VENTILATION-PERFUSION RATIO IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_sort | evaluation of ventilation perfusion ratio in chronic obstructive pulmonary disease |
| topic | ventilation-perfusion ratio dead space chronic obstructive pulmonary disease volumetric capnography. |
| url | https://doi.org/10.25005/2074-0581-2021-23-1-25-31 |
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