Breast Cancer in Young Women: Pathologic and Immunohistochemical Features
A young woman with breast cancer is considered to be a woman younger than 40. According to the literature, breast cancer in the population of young women usually is of a higher histologic grade, unfavorable hormonal status, and overall higher mortality rate when compared with breast cancer occurring...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2018-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/315417 |
| _version_ | 1797207547774500864 |
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| author | Ivan Erić Anamarija Petek Erić Jozo Kristek Ivan Koprivčić Marko Babić |
| author_facet | Ivan Erić Anamarija Petek Erić Jozo Kristek Ivan Koprivčić Marko Babić |
| author_sort | Ivan Erić |
| collection | DOAJ |
| description | A young woman with breast cancer is considered to be a woman younger than 40. According to the literature, breast cancer in the population of young women usually is of a higher histologic grade, unfavorable hormonal status, and overall higher mortality rate when compared with breast cancer occurring in older population. We compared pathologic and immunohistochemical features of breast carcinoma in women under 40 years of age with the respective features in women over 60 years of age. The following parameters were observed in these two groups: tumor size, lymph node status, histologic grade, hormonal receptor status, Ki-67 prognostic index, Her2/neu status, and histologic type of the tumor. Early onset breast carcinoma was found to have a higher frequency of tumor grade 3 (29% vs. 17%) and estrogen receptor negativity (45% vs. 23%). In the group of young women, breast carcinoma was mostly multicentric (23% vs. 5%), triple-negative (32% vs. 10%), and was found to have higher proliferation index Ki-67 (25% vs. 10%). Our results confirmed differences between the young and older groups of patients. In the group of young women, we found predominantly unfavorable prognostic parameters of the disease. |
| first_indexed | 2024-04-24T09:24:39Z |
| format | Article |
| id | doaj.art-64aef14623434a23b82cef82a692cbd5 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:24:39Z |
| publishDate | 2018-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-64aef14623434a23b82cef82a692cbd52024-04-15T15:16:59ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512018-01-0157.3.49750110.20471/acc.2018.57.03.13Breast Cancer in Young Women: Pathologic and Immunohistochemical FeaturesIvan Erić0Anamarija Petek Erić1Jozo Kristek2Ivan Koprivčić3Marko Babić4Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Osijek University Hospital Centre, Osijek, CroatiaFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Osijek University Hospital Centre, Osijek, CroatiaFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Osijek University Hospital Centre, Osijek, CroatiaOsijek University Hospital Centre, Osijek, CroatiaOsijek University Hospital Centre, Osijek, CroatiaA young woman with breast cancer is considered to be a woman younger than 40. According to the literature, breast cancer in the population of young women usually is of a higher histologic grade, unfavorable hormonal status, and overall higher mortality rate when compared with breast cancer occurring in older population. We compared pathologic and immunohistochemical features of breast carcinoma in women under 40 years of age with the respective features in women over 60 years of age. The following parameters were observed in these two groups: tumor size, lymph node status, histologic grade, hormonal receptor status, Ki-67 prognostic index, Her2/neu status, and histologic type of the tumor. Early onset breast carcinoma was found to have a higher frequency of tumor grade 3 (29% vs. 17%) and estrogen receptor negativity (45% vs. 23%). In the group of young women, breast carcinoma was mostly multicentric (23% vs. 5%), triple-negative (32% vs. 10%), and was found to have higher proliferation index Ki-67 (25% vs. 10%). Our results confirmed differences between the young and older groups of patients. In the group of young women, we found predominantly unfavorable prognostic parameters of the disease.https://hrcak.srce.hr/file/315417Breast neoplasmsFemaleLymph codesCroatia |
| spellingShingle | Ivan Erić Anamarija Petek Erić Jozo Kristek Ivan Koprivčić Marko Babić Breast Cancer in Young Women: Pathologic and Immunohistochemical Features Acta Clinica Croatica Breast neoplasms Female Lymph codes Croatia |
| title | Breast Cancer in Young Women: Pathologic and Immunohistochemical Features |
| title_full | Breast Cancer in Young Women: Pathologic and Immunohistochemical Features |
| title_fullStr | Breast Cancer in Young Women: Pathologic and Immunohistochemical Features |
| title_full_unstemmed | Breast Cancer in Young Women: Pathologic and Immunohistochemical Features |
| title_short | Breast Cancer in Young Women: Pathologic and Immunohistochemical Features |
| title_sort | breast cancer in young women pathologic and immunohistochemical features |
| topic | Breast neoplasms Female Lymph codes Croatia |
| url | https://hrcak.srce.hr/file/315417 |
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