Effects of aromatase inhibitors on the ocular surface microenvironment
AIM: To analyze the effects of aromatase inhibitors(AIs)on the ocular surface microenvironment of the users.METHODS: A cross-sectional observational study was conducted. The study included postmenopausal women who received AIs treatment at galactophore department of our hospital from November 2022 t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-10-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/10/202310026.pdf |
| _version_ | 1797681995507040256 |
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| author | Peng Xu Yuan-Yuan Zhao Chen Yuan Chao Liu |
| author_facet | Peng Xu Yuan-Yuan Zhao Chen Yuan Chao Liu |
| author_sort | Peng Xu |
| collection | DOAJ |
| description | AIM: To analyze the effects of aromatase inhibitors(AIs)on the ocular surface microenvironment of the users.METHODS: A cross-sectional observational study was conducted. The study included postmenopausal women who received AIs treatment at galactophore department of our hospital from November 2022 to May 2023. Participants were divided into two groups based on the mechanism of AIs: the steroidal group and the non-steroidal group. The control group consisted of age-matched women who underwent occupational health examinations. All participants completed the ocular surface disease index(OSDI)questionnaire and underwent detailed ophthalmic examinations, including best-corrected visual acuity, intraocular pressure, axial length, corneal curvature, radius of curvature of curved lacrimal river surface, tear osmolarity, tear film break-up time, corneal fluorescein staining score, Schirmer Ⅰ test, and meibomian gland infrared score.RESULTS: There were no statistically significant differences in age, best-corrected visual acuity, intraocular pressure, axial length, and corneal curvature between control group and steroidal and non-steroidal group(P>0.05). The duration of drug treatment between the steroidal group and the non-steroidal group also showed no statistically significant difference(P>0.05). However, statistically significant differences were observed between the control group and the steroidal and non-steroidal group in OSDI scores, radius of curvature of curved lacrimal river surface, tear osmolarity, tear film break-up time, corneal fluorescein staining score, Schirmer Ⅰ test, and meibomian gland infrared score(P<0.05). The Schirmer Ⅰ test also showed statistically significant differences between the steroidal group and the non-steroidal group(P<0.05), while other data showed no statistically significant differences(P>0.05).CONCLUSION: Postmenopausal patients receiving AIs treatment experienced significant changes in the ocular microenvironment, with both decreased tear secretion and excessive tear evaporation contributing to the occurrence of dry eye. Notably, patients receiving non-steroidal AIs treatment showed a more significant reduction in main lacrimal gland secretion. |
| first_indexed | 2024-03-11T23:53:07Z |
| format | Article |
| id | doaj.art-64afe43b8a4f4464904da403f776b8f3 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-11T23:53:07Z |
| publishDate | 2023-10-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-64afe43b8a4f4464904da403f776b8f32023-09-19T03:02:27ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-10-0123101741174410.3980/j.issn.1672-5123.2023.10.26202310026Effects of aromatase inhibitors on the ocular surface microenvironmentPeng Xu0Yuan-Yuan Zhao1Chen Yuan2Chao Liu3Affiliated Qingdao Central Hospital of Qingdao University;Qingdao Cancer Hospital, Qingdao 266042, Shandong Province, ChinaAffiliated Qingdao Central Hospital of Qingdao University;Qingdao Cancer Hospital, Qingdao 266042, Shandong Province, ChinaAffiliated Qingdao Central Hospital of Qingdao University;Qingdao Cancer Hospital, Qingdao 266042, Shandong Province, ChinaAffiliated Qingdao Central Hospital of Qingdao University;Qingdao Cancer Hospital, Qingdao 266042, Shandong Province, ChinaAIM: To analyze the effects of aromatase inhibitors(AIs)on the ocular surface microenvironment of the users.METHODS: A cross-sectional observational study was conducted. The study included postmenopausal women who received AIs treatment at galactophore department of our hospital from November 2022 to May 2023. Participants were divided into two groups based on the mechanism of AIs: the steroidal group and the non-steroidal group. The control group consisted of age-matched women who underwent occupational health examinations. All participants completed the ocular surface disease index(OSDI)questionnaire and underwent detailed ophthalmic examinations, including best-corrected visual acuity, intraocular pressure, axial length, corneal curvature, radius of curvature of curved lacrimal river surface, tear osmolarity, tear film break-up time, corneal fluorescein staining score, Schirmer Ⅰ test, and meibomian gland infrared score.RESULTS: There were no statistically significant differences in age, best-corrected visual acuity, intraocular pressure, axial length, and corneal curvature between control group and steroidal and non-steroidal group(P>0.05). The duration of drug treatment between the steroidal group and the non-steroidal group also showed no statistically significant difference(P>0.05). However, statistically significant differences were observed between the control group and the steroidal and non-steroidal group in OSDI scores, radius of curvature of curved lacrimal river surface, tear osmolarity, tear film break-up time, corneal fluorescein staining score, Schirmer Ⅰ test, and meibomian gland infrared score(P<0.05). The Schirmer Ⅰ test also showed statistically significant differences between the steroidal group and the non-steroidal group(P<0.05), while other data showed no statistically significant differences(P>0.05).CONCLUSION: Postmenopausal patients receiving AIs treatment experienced significant changes in the ocular microenvironment, with both decreased tear secretion and excessive tear evaporation contributing to the occurrence of dry eye. Notably, patients receiving non-steroidal AIs treatment showed a more significant reduction in main lacrimal gland secretion.http://ies.ijo.cn/cn_publish/2023/10/202310026.pdfdry eyearomatase inhibitorbreast cancerocular surface microenvironment |
| spellingShingle | Peng Xu Yuan-Yuan Zhao Chen Yuan Chao Liu Effects of aromatase inhibitors on the ocular surface microenvironment Guoji Yanke Zazhi dry eye aromatase inhibitor breast cancer ocular surface microenvironment |
| title | Effects of aromatase inhibitors on the ocular surface microenvironment |
| title_full | Effects of aromatase inhibitors on the ocular surface microenvironment |
| title_fullStr | Effects of aromatase inhibitors on the ocular surface microenvironment |
| title_full_unstemmed | Effects of aromatase inhibitors on the ocular surface microenvironment |
| title_short | Effects of aromatase inhibitors on the ocular surface microenvironment |
| title_sort | effects of aromatase inhibitors on the ocular surface microenvironment |
| topic | dry eye aromatase inhibitor breast cancer ocular surface microenvironment |
| url | http://ies.ijo.cn/cn_publish/2023/10/202310026.pdf |
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