Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer

Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer

Abstract Background Although gemcitabine has been considered as the first-line drug for advanced pancreatic cancer (PC), development of resistance to gemcitabine severely limits the effectiveness of this chemotherapy, and the underlying mechanism of gemcitabine resistance remains unclear. Various fa...

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Bibliographic Details
Main Authors: Jianyou Gu, Wenjie Huang, Xianxing Wang, Junfeng Zhang, Tian Tao, Yao Zheng, Songsong Liu, Jiali Yang, Zhe-Sheng Chen, Chao-Yun Cai, Jinsui Li, Huaizhi Wang, Yingfang Fan
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Molecular Cancer
Subjects:
Hsa-miR-3178
RhoB
Gemcitabine resistance
PI3K/Akt
Pancreatic cancer
ABC transporters
Online Access:https://doi.org/10.1186/s12943-022-01587-9

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