Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study
Abstract Background The presence of altered pulmonary hemodynamics in adult patients with atrial septal defect (ASD) is common. However, there are no observational studies which evaluate the impact of altered pulmonary hemodynamics on the 6-min walk test (6MWT) result. This study aimed to investigat...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13019-018-0725-6 |
| _version_ | 1818131297219903488 |
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| author | Supomo Supomo Handy Darmawan Adika Zhulhi Arjana |
| author_facet | Supomo Supomo Handy Darmawan Adika Zhulhi Arjana |
| author_sort | Supomo Supomo |
| collection | DOAJ |
| description | Abstract Background The presence of altered pulmonary hemodynamics in adult patients with atrial septal defect (ASD) is common. However, there are no observational studies which evaluate the impact of altered pulmonary hemodynamics on the 6-min walk test (6MWT) result. This study aimed to investigate the role of pulmonary hemodynamics in determining 6MWT result of patients with ASD. Method Forty-six consecutive adult patients with ASD were included in this study. Right heart catheterization was performed to obtain the pulmonary hemodynamics profile. Meanwhile, 6MWT was presented as high or low with cut-off point 350 m. Receiver operating characteristic (ROC) was used for analytical methods. Result Abnormal functional capacity was indicated by ROC result of mPAP cut-off value of > 24 mmHg (p = 0.0243; AUC = 0.681). The value of PVR > 3.42 woods unit (WU) showed high specificity in determining abnormal functional capacity (p = 0.0069; AUC = 0.713). Flow ratio with cut-off point ≤4.89 had the highest sensitivity (100%) (p = 0.8300; AUC = 0.520). Conclusion Pulmonary hemodynamics can serve as an indicator of 6MWT result in adult ASD patients with values of mPAP> 24 mmHg and PVR > 3.42 WU. |
| first_indexed | 2024-12-11T08:18:41Z |
| format | Article |
| id | doaj.art-64b2225e5d32441aae7c1eaac52adddc |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-11T08:18:41Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-64b2225e5d32441aae7c1eaac52adddc2022-12-22T01:14:42ZengBMCJournal of Cardiothoracic Surgery1749-80902018-05-011311510.1186/s13019-018-0725-6Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational studySupomo Supomo0Handy Darmawan1Adika Zhulhi Arjana2Department of Thoracic and Cardiovascular Surgery, Dr. Sardjito General Hospital, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MadaFaculty of Medicine, Universitas Islam IndonesiaFaculty of Medicine, Universitas Islam IndonesiaAbstract Background The presence of altered pulmonary hemodynamics in adult patients with atrial septal defect (ASD) is common. However, there are no observational studies which evaluate the impact of altered pulmonary hemodynamics on the 6-min walk test (6MWT) result. This study aimed to investigate the role of pulmonary hemodynamics in determining 6MWT result of patients with ASD. Method Forty-six consecutive adult patients with ASD were included in this study. Right heart catheterization was performed to obtain the pulmonary hemodynamics profile. Meanwhile, 6MWT was presented as high or low with cut-off point 350 m. Receiver operating characteristic (ROC) was used for analytical methods. Result Abnormal functional capacity was indicated by ROC result of mPAP cut-off value of > 24 mmHg (p = 0.0243; AUC = 0.681). The value of PVR > 3.42 woods unit (WU) showed high specificity in determining abnormal functional capacity (p = 0.0069; AUC = 0.713). Flow ratio with cut-off point ≤4.89 had the highest sensitivity (100%) (p = 0.8300; AUC = 0.520). Conclusion Pulmonary hemodynamics can serve as an indicator of 6MWT result in adult ASD patients with values of mPAP> 24 mmHg and PVR > 3.42 WU.http://link.springer.com/article/10.1186/s13019-018-0725-6Atrial septal defectCardiac catheterizationHemodynamicPulmonary hypertension |
| spellingShingle | Supomo Supomo Handy Darmawan Adika Zhulhi Arjana Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study Journal of Cardiothoracic Surgery Atrial septal defect Cardiac catheterization Hemodynamic Pulmonary hypertension |
| title | Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study |
| title_full | Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study |
| title_fullStr | Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study |
| title_full_unstemmed | Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study |
| title_short | Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study |
| title_sort | role of pulmonary hemodynamics in determining 6 minute walk test result in atrial septal defect an observational study |
| topic | Atrial septal defect Cardiac catheterization Hemodynamic Pulmonary hypertension |
| url | http://link.springer.com/article/10.1186/s13019-018-0725-6 |
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