IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown by the absence of efficient polyclonal anti-tum...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16471-7 |
| _version_ | 1818422386020581376 |
|---|---|
| author | Irini Evnouchidou Pascal Chappert Samira Benadda Andres Zucchetti Mirjana Weimershaus Marcelle Bens Vivien Caillens Despoina Koumantou Sophie Lotersztajn Peter van Endert Jean Davoust Pierre Guermonprez Claire Hivroz David A. Gross Loredana Saveanu |
| author_facet | Irini Evnouchidou Pascal Chappert Samira Benadda Andres Zucchetti Mirjana Weimershaus Marcelle Bens Vivien Caillens Despoina Koumantou Sophie Lotersztajn Peter van Endert Jean Davoust Pierre Guermonprez Claire Hivroz David A. Gross Loredana Saveanu |
| author_sort | Irini Evnouchidou |
| collection | DOAJ |
| description | T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown by the absence of efficient polyclonal anti-tumour response in mice with T-specific conditional deletion of IRAP. |
| first_indexed | 2024-12-14T13:25:25Z |
| format | Article |
| id | doaj.art-64b251bfea0c4668a8923bf82ed550e8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:25:25Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-64b251bfea0c4668a8923bf82ed550e82022-12-21T22:59:50ZengNature PortfolioNature Communications2041-17232020-06-0111111610.1038/s41467-020-16471-7IRAP-dependent endosomal T cell receptor signalling is essential for T cell responsesIrini Evnouchidou0Pascal Chappert1Samira Benadda2Andres Zucchetti3Mirjana Weimershaus4Marcelle Bens5Vivien Caillens6Despoina Koumantou7Sophie Lotersztajn8Peter van Endert9Jean Davoust10Pierre Guermonprez11Claire Hivroz12David A. Gross13Loredana Saveanu14Université de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252InovarionUniversité de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252Paris Sciences and Lettres Research University, Institut Curie, INSERM U932Université de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252Université de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252Université de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252Université de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252Université de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252Université de Paris, Institut Necker Enfants Malades, INSERM U1151, CNRS U8253Université de Paris, Institut Necker Enfants Malades, INSERM U1151, CNRS U8253Université de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252Paris Sciences and Lettres Research University, Institut Curie, INSERM U932Université de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252Université de Paris, Centre de recherche sur l’inflammation, INSERM U1149, CNRS ERL8252T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown by the absence of efficient polyclonal anti-tumour response in mice with T-specific conditional deletion of IRAP.https://doi.org/10.1038/s41467-020-16471-7 |
| spellingShingle | Irini Evnouchidou Pascal Chappert Samira Benadda Andres Zucchetti Mirjana Weimershaus Marcelle Bens Vivien Caillens Despoina Koumantou Sophie Lotersztajn Peter van Endert Jean Davoust Pierre Guermonprez Claire Hivroz David A. Gross Loredana Saveanu IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses Nature Communications |
| title | IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses |
| title_full | IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses |
| title_fullStr | IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses |
| title_full_unstemmed | IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses |
| title_short | IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses |
| title_sort | irap dependent endosomal t cell receptor signalling is essential for t cell responses |
| url | https://doi.org/10.1038/s41467-020-16471-7 |
| work_keys_str_mv | AT irinievnouchidou irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT pascalchappert irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT samirabenadda irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT andreszucchetti irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT mirjanaweimershaus irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT marcellebens irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT viviencaillens irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT despoinakoumantou irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT sophielotersztajn irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT petervanendert irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT jeandavoust irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT pierreguermonprez irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT clairehivroz irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT davidagross irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses AT loredanasaveanu irapdependentendosomaltcellreceptorsignallingisessentialfortcellresponses |