Morphogenesis of vascular and neuronal networks and the relationships between their remodeling processes
Vascular and neuronal networks represent important examples of body structures created by processes of branching morphogenesis. Migration to an appropriate target in both axons and blood vessels are mediated by chemo-repulsive and attractive signals and the proximity of nerves and blood vessels sugg...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923022001368 |
| _version_ | 1797367829252538368 |
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| author | Domenico Ribatti Diego Guidolin |
| author_facet | Domenico Ribatti Diego Guidolin |
| author_sort | Domenico Ribatti |
| collection | DOAJ |
| description | Vascular and neuronal networks represent important examples of body structures created by processes of branching morphogenesis. Migration to an appropriate target in both axons and blood vessels are mediated by chemo-repulsive and attractive signals and the proximity of nerves and blood vessels suggest that there may be a molecular crosstalk and common cues between nerves and blood vessels. Vascular endothelial growth factor (VEGF), a key angiogenetic factor, has direct effects on the nervous system in terms of axon outgrowth and survival. Conversely, nerve growth factor (NGF), a well-known neurotropic molecule, exhibits angiogenic properties. Available data on the morphogenesis of vascular and neuronal networks and on the relationships between their remodeling processes will be the focus of the present study. |
| first_indexed | 2024-03-08T17:22:41Z |
| format | Article |
| id | doaj.art-64b2ea13f61e4f40b050ec887301ea35 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-08T17:22:41Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-64b2ea13f61e4f40b050ec887301ea352024-01-03T04:11:26ZengElsevierBrain Research Bulletin1873-27472022-08-011866269Morphogenesis of vascular and neuronal networks and the relationships between their remodeling processesDomenico Ribatti0Diego Guidolin1Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, ItalyCorrespondence to: Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Policlinico - Piazza G. Cesare, 11, 70124 Bari, Italy.; Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, ItalyVascular and neuronal networks represent important examples of body structures created by processes of branching morphogenesis. Migration to an appropriate target in both axons and blood vessels are mediated by chemo-repulsive and attractive signals and the proximity of nerves and blood vessels suggest that there may be a molecular crosstalk and common cues between nerves and blood vessels. Vascular endothelial growth factor (VEGF), a key angiogenetic factor, has direct effects on the nervous system in terms of axon outgrowth and survival. Conversely, nerve growth factor (NGF), a well-known neurotropic molecule, exhibits angiogenic properties. Available data on the morphogenesis of vascular and neuronal networks and on the relationships between their remodeling processes will be the focus of the present study.http://www.sciencedirect.com/science/article/pii/S0361923022001368AngiogenesisMorphogenesis: neurogenesisNGFVEGF |
| spellingShingle | Domenico Ribatti Diego Guidolin Morphogenesis of vascular and neuronal networks and the relationships between their remodeling processes Brain Research Bulletin Angiogenesis Morphogenesis: neurogenesis NGF VEGF |
| title | Morphogenesis of vascular and neuronal networks and the relationships between their remodeling processes |
| title_full | Morphogenesis of vascular and neuronal networks and the relationships between their remodeling processes |
| title_fullStr | Morphogenesis of vascular and neuronal networks and the relationships between their remodeling processes |
| title_full_unstemmed | Morphogenesis of vascular and neuronal networks and the relationships between their remodeling processes |
| title_short | Morphogenesis of vascular and neuronal networks and the relationships between their remodeling processes |
| title_sort | morphogenesis of vascular and neuronal networks and the relationships between their remodeling processes |
| topic | Angiogenesis Morphogenesis: neurogenesis NGF VEGF |
| url | http://www.sciencedirect.com/science/article/pii/S0361923022001368 |
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