The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses
The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope. Protein intrinsic disorder is an inherent feature of this selective transport barrier and is also a feature of the nuclea...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/12/2654 |
| _version_ | 1797545169793318912 |
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| author | Jacinta M. Wubben Sarah C. Atkinson Natalie A. Borg |
| author_facet | Jacinta M. Wubben Sarah C. Atkinson Natalie A. Borg |
| author_sort | Jacinta M. Wubben |
| collection | DOAJ |
| description | The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope. Protein intrinsic disorder is an inherent feature of this selective transport barrier and is also a feature of the nuclear transport receptors that facilitate the active nuclear transport of cargo, and the nuclear transport signals on the cargo itself. Furthermore, intrinsic disorder is an inherent feature of viral proteins and viral strategies to disrupt host nucleocytoplasmic transport to benefit their replication. In this review, we highlight the role that intrinsic disorder plays in the nuclear transport of host and viral proteins. We also describe viral subversion mechanisms of the host nuclear transport machinery in which intrinsic disorder is a feature. Finally, we discuss nuclear import and export as therapeutic targets for viral infectious disease. |
| first_indexed | 2024-03-10T14:11:40Z |
| format | Article |
| id | doaj.art-64b3b15ab7c542bebd11f16218a28336 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:11:40Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-64b3b15ab7c542bebd11f16218a283362023-11-21T00:09:41ZengMDPI AGCells2073-44092020-12-01912265410.3390/cells9122654The Role of Protein Disorder in Nuclear Transport and in Its Subversion by VirusesJacinta M. Wubben0Sarah C. Atkinson1Natalie A. Borg2Chronic Infectious and Inflammatory Diseases Research, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, AustraliaChronic Infectious and Inflammatory Diseases Research, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, AustraliaChronic Infectious and Inflammatory Diseases Research, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, AustraliaThe transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope. Protein intrinsic disorder is an inherent feature of this selective transport barrier and is also a feature of the nuclear transport receptors that facilitate the active nuclear transport of cargo, and the nuclear transport signals on the cargo itself. Furthermore, intrinsic disorder is an inherent feature of viral proteins and viral strategies to disrupt host nucleocytoplasmic transport to benefit their replication. In this review, we highlight the role that intrinsic disorder plays in the nuclear transport of host and viral proteins. We also describe viral subversion mechanisms of the host nuclear transport machinery in which intrinsic disorder is a feature. Finally, we discuss nuclear import and export as therapeutic targets for viral infectious disease.https://www.mdpi.com/2073-4409/9/12/2654protein intrinsic disordernuclear transport receptorsnuclear export sequencenuclear import sequencenucleoporinsviral infection |
| spellingShingle | Jacinta M. Wubben Sarah C. Atkinson Natalie A. Borg The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses Cells protein intrinsic disorder nuclear transport receptors nuclear export sequence nuclear import sequence nucleoporins viral infection |
| title | The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses |
| title_full | The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses |
| title_fullStr | The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses |
| title_full_unstemmed | The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses |
| title_short | The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses |
| title_sort | role of protein disorder in nuclear transport and in its subversion by viruses |
| topic | protein intrinsic disorder nuclear transport receptors nuclear export sequence nuclear import sequence nucleoporins viral infection |
| url | https://www.mdpi.com/2073-4409/9/12/2654 |
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