Beta-amyloid oligomers: recent developments
Recent studies point to a critical role of soluble β-amyloid oligomers in the pathogenesis of one of the most common neurodegenerative diseases, Alzheimer's disease (AD). Beta-amyloid peptides are cleavage products of a ubiquitously expressed protein, the amyloid precursor protein. Early studie...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2011-06-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc.2011.019 |
| _version_ | 1818677699978199040 |
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| author | Borutaite Vilmante Morkuniene Ramune Valincius Gintaras |
| author_facet | Borutaite Vilmante Morkuniene Ramune Valincius Gintaras |
| author_sort | Borutaite Vilmante |
| collection | DOAJ |
| description | Recent studies point to a critical role of soluble β-amyloid oligomers in the pathogenesis of one of the most common neurodegenerative diseases, Alzheimer's disease (AD). Beta-amyloid peptides are cleavage products of a ubiquitously expressed protein, the amyloid precursor protein. Early studies suggested that accumulation of extracellular β-amyloid aggregates are the most toxic species causing synaptic dysfunction and neuronal loss in particular regions of the brain (neurobiological features underlying cognitive decline of the AD patients). In recent years, a shift of pardigm occurred, and now there is accumulating evidence that soluble oligomeric forms of the peptide are the most toxic to neuronal cells. In this review, we discuss recent findings on the toxic effects of amyloid-β oligomers, their physico-chemical properties and the possible pathways of their formation in vitro and in vivo. |
| first_indexed | 2024-12-17T09:03:32Z |
| format | Article |
| id | doaj.art-64b49f1b24f64c7496626683c525e37a |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T09:03:32Z |
| publishDate | 2011-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-64b49f1b24f64c7496626683c525e37a2022-12-21T21:55:37ZengDe GruyterBiomolecular Concepts1868-50211868-503X2011-06-012321122210.1515/bmc.2011.019Beta-amyloid oligomers: recent developmentsBorutaite Vilmante0Morkuniene Ramune1Valincius Gintaras2Institute for Biomedical Research, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50009 Kaunas, LithuaniaInstitute for Biomedical Research, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50009 Kaunas, LithuaniaInstitute of Biochemistry, Vilnius University, Mokslininku Str. 12, LT-08662 Vilnius, LithuaniaRecent studies point to a critical role of soluble β-amyloid oligomers in the pathogenesis of one of the most common neurodegenerative diseases, Alzheimer's disease (AD). Beta-amyloid peptides are cleavage products of a ubiquitously expressed protein, the amyloid precursor protein. Early studies suggested that accumulation of extracellular β-amyloid aggregates are the most toxic species causing synaptic dysfunction and neuronal loss in particular regions of the brain (neurobiological features underlying cognitive decline of the AD patients). In recent years, a shift of pardigm occurred, and now there is accumulating evidence that soluble oligomeric forms of the peptide are the most toxic to neuronal cells. In this review, we discuss recent findings on the toxic effects of amyloid-β oligomers, their physico-chemical properties and the possible pathways of their formation in vitro and in vivo.https://doi.org/10.1515/bmc.2011.019alzheimer's diseaseβ-amyloidneuronal cell death |
| spellingShingle | Borutaite Vilmante Morkuniene Ramune Valincius Gintaras Beta-amyloid oligomers: recent developments Biomolecular Concepts alzheimer's disease β-amyloid neuronal cell death |
| title | Beta-amyloid oligomers: recent developments |
| title_full | Beta-amyloid oligomers: recent developments |
| title_fullStr | Beta-amyloid oligomers: recent developments |
| title_full_unstemmed | Beta-amyloid oligomers: recent developments |
| title_short | Beta-amyloid oligomers: recent developments |
| title_sort | beta amyloid oligomers recent developments |
| topic | alzheimer's disease β-amyloid neuronal cell death |
| url | https://doi.org/10.1515/bmc.2011.019 |
| work_keys_str_mv | AT borutaitevilmante betaamyloidoligomersrecentdevelopments AT morkunieneramune betaamyloidoligomersrecentdevelopments AT valinciusgintaras betaamyloidoligomersrecentdevelopments |