Mechanistic basis of the increased methylation activity of the SETD2 protein lysine methyltransferase towards a designed super-substrate peptide

Mechanistic basis of the increased methylation activity of the SETD2 protein lysine methyltransferase towards a designed super-substrate peptide

The SET-domain containing protein 2 (SETD2) is a protein lysine methyltransferase that has been shown to methylate the super-substrate peptide ssK36 100 times faster than the corresponding natural H3K36 peptide. Here, a combination of molecular dynamics simulations and biochemical experiments are ap...

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Bibliographic Details
Main Authors: Philipp Schnee, Michel Choudalakis, Sara Weirich, Mina S. Khella, Henrique Carvalho, Jürgen Pleiss, Albert Jeltsch
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-022-00753-w

Internet

https://doi.org/10.1038/s42004-022-00753-w

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